Associação entre o Produto da Acumulação Lipídica e marcadores aterogênicos é independente do sexo, idade e uso de medicamentos hipolipemiantes

Abstract

Objective: This study aimed to evaluate the association between Lipid Accumulation Product and biochemical markers and verify how it is affected by sex, age and medication use. Methods: This is a cross-sectional study including biochemical, clinical, demographic and anthropometric data from 617 individuals, both sexes, between 20 and 59 years old, without previous cardiovascular event. Data was collected between 2000 and 2014.The influence of Lipid Accumulation Product on the biochemical variables levels was assessed by multiple linear regression analysis for men and women. Statistical analyzes were performed using SPSS version 20.0 software at significance level of p<0.05. Results: Both sexes presented overweight and increased waist circumference. The median Lipid Accumulation Product was 57.8 and men showed higher values than women. In both sexes, the Lipid Accumulation Product significantly influenced the total cholesterol and high-density lipoprotein levels and these results were adjustment variables (age and hypolipidemic agents) independent. Conclusions: Results showed that Lipid Accumulation Product was associated with low HDL levels and increased concentrations of TC regardless of sexes, age and lipid-lowering drugs.

Visceral adiposity indices and cardiometabolic risk markers in patients with hypertension

“…LAP is proposed as an index that reflects the physiological and anatomical changes that are associated with visceral fat deposition ( 26 ), with a predictive power superior to other parameters, such as BMI, to identify risk for cardiovascular outcomes and diabetes ( 22 , 23 ), as well as all-cause mortality prediction ( 27 , 28 ). In previous national studies ( 8 , 23 , 29 ), LAP was found to be significantly associated with classical cardiovascular biomarkers, which is in agreement with our findings.…”