Associated changes of bone morphogenetic proteins levels in human colorectal cancer during tumor progression

Yang, Weng‐Lang; Makizumi, Ryouji; Dong, Huali; Ravikumar, Thanjavur S.

doi:10.1016/j.jamcollsurg.2005.06.202

Cited by 1 publication

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“…While previous studies have examined the impact of polymorphisms within BMPs or their expression on colorectal cancer (CRC) [ 53 , 54 , 55 , 56 , 57 ], only the BMP3 gene has been previously identified as hypermethylated in CRC tissue [ 58 , 59 ]. In our comprehensive study of miRNA-target gene expressions in colorectal cancer, we have previously identified the overexpression of the BMP4 gene in colorectal cancer tissue [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

In Silico Gene Prioritization Highlights the Significance of Bone Morphogenetic Protein 4 (BMP4) Promoter Methylation across All Methylation Clusters in Colorectal Cancer

Skok

Hauptman

2023

IJMS

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The cytosine–phosphate–guanine (CpG) island methylator phenotype (CIMP) represents one of the pathways involved in the development of colorectal cancer, characterized by genome-wide hypermethylation. To identify samples exhibiting hypermethylation, we used unsupervised hierarchical clustering on genome-wide methylation data. This clustering analysis revealed the presence of four distinct subtypes within the tumor samples, namely, CIMP-H, CIMP-L, cluster 3, and cluster 4. These subtypes demonstrated varying levels of methylation, categorized as high, intermediate, and very low. To gain further insights, we mapped significant probes from all clusters to Ensembl Regulatory build 89, with a specific focus on those located within promoter regions or bound regions. By intersecting the methylated promoter and bound regions across all methylation subtypes, we identified a total of 253 genes exhibiting aberrant methylation patterns in the promoter regions across all four subtypes of colorectal cancer. Among these genes, our comprehensive genome-wide analysis highlights bone morphogenic protein 4 (BMP4) as the most prominent candidate. This significant finding was derived through the utilization of various bioinformatics tools, emphasizing the potential role of BMP4 in colorectal cancer development and progression.

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