Associated factors and safety of the rapidly achieving first therapeutic target of warfarin in hospitalized patients: a retrospective cohort study

Abstract

BackgroundWarfarin is a commonly used anticoagulant drug in clinical practice. Rapidly achieving the rst therapeutic international normalized ratio (INR) of warfarin may reduce the hospital length of stay.However, little research has been carried out to evaluate the in uencing factors and the safety of rapidly achieving the rst therapeutic INR target of warfarin. AimTo investigate the associated factors and the safety of rapidly achieving the rst therapeutic INR target of warfarin.rst therapeutic INR during warfarin treatment.2. Rapid achievement of rst therapeutic INR can reduce post-medication hospital length of stay.3. Hospitalized patients aged ≤ 65 years or with a body mass index ≥ 24 kg/m 2 might need a higher initial dose of warfarin to achieve the rst INR rapidly after warfarin therapy for the rst time.4. Monitoring INR closer is recommended to ensure the safety of hospitalized patients who achieved the rst INR ≥ 1.8 within 6 days after warfarin therapy for the rst time.