Associated Factors for Prostate Enlargement in Chinese Adult Men Aged <40 Receiving Checkups

Abstract

Purpose. Prostate enlargement (PE) is an increase in prostate volume in morphology. PE was also observed in some patients aged &lt;40 with chronic prostatitis. This study aimed to explore the associated factors for PE in Chinese adult men aged &lt;40. Methods. The medical records of 1851 consecutive Chinese adult men aged &lt;40 in a single center were retrospectively analyzed. The checkup indicator characteristics between the PE and non-PE groups were compared by univariate analysis, and the associated factors were analyzed by multivariate analysis. Results. The overall prevalence of PE (defined as prostate volume ≥ 20 ml) in adult men aged &lt; 40 was 10.4%. Age and the proportions of subjects with prostate calcification or hypertension were different between the PE and non-PE groups ( P &lt; 0.05 ). Multivariate logistic analysis showed that prostate calcification (odds ratio [OR], 1.831; 95% confidence interval [CI], 1.281–2.619; P = 0.001 ), hypertension (OR, 1.528; 95% CI, 1.125–2.076; P = 0.007 ), and age (OR, 1.117; 95% CI, 1.078–1.159; P &lt; 0.001 ) were associated factors for PE in adult men aged &lt;40. Conclusions. The prevalence of PE in Chinese adult check-up men aged &lt;40 was not rare. In addition to age, prostate calcification and hypertension were associated factors for PE in Chinese adult men aged &lt;40.

Analysis of risk factors for benign prostate enlargement with prostate calcification

“…Prostate cancer is one of the most frequently diagnosed malignancies among men worldwide, and prostate microcalcification has garnered attention as a potential prognostic marker for bone metastasis in this disease [11]. Previous research has indicated that while it often arises as a consequence of scar tissue formation following prostatitis resolution, several factors, including chronic prostatitis, prostatic urine retention, prostatic duct stenosis, abnormalities in calcium and phosphorus metabolism, and psychosocial factors, may contribute to its development [12][13][14]. Epidemiological studies have also linked poor dietary habits (such as irregular breakfasts and consumption of fatty snacks), alcohol consumption, and certain work-related habits (like prolonged sitting, late-night work, and the habit of holding in urine) to an increased risk of calcification [15,16].…”