Associated factors of umbilical cord blood collection quality

Faivre, Lionel; Couzin, Chloé; Boucher, Hélène; Domet, Thomas; Desproges, André; Sibony, Olivier; Bechard, Marina; Larghero, Jérôme; Cras, Audrey

doi:10.1111/trf.14447

Cited by 11 publications

(21 citation statements)

References 78 publications

(606 reference statements)

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“…To date, some studies have observed that delayed umbilical cord clamping and the in utero collection mode have some negative correlations with the volume of UCB collection [4,5]. The current results may be the same for the latter.…”

Section: Discussionsupporting

confidence: 52%

“…In addition, some obstetric factors such as greater infant and placental weights have also been proposed as effective factors facilitating UCB collection with sufficient cellular richness [4,5,13]. However, the weights of Japanese infants and placentae may be lower than those in the countries reported previously [4,5,13].…”

Section: Discussionmentioning

confidence: 99%

“…In Japan, about 30% of hematopoietic stem cell transplantation is now performed using UCB [2,3]. Because the limited number of cells still remains a problem restricting UCB use, maintenance of the quality of harvested UCB will be essential to decreasing the number of discarded units [4,5]. Collected UCB is cryopreserved after removing red blood cells; however, the presence of a large amount of clots may lead to the deterioration of cord blood quality.…”

Section: Introductionmentioning

confidence: 99%

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Factors Associated With Umbilical Cord Blood Collection Quality in Japan

Suzuki

Kimura

Hara³

et al. 2020

J Hematol

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Background: Umbilical cord blood (UCB) has become an established alternative source of hematopoietic stem cells with marrow and postmobilization peripheral blood. The presence of a large amount of clots may lead to the deterioration of cord blood quality. To improve UCB quality as a source of hematopoietic stem cells in Japan, we examined factors associated with UCB collection methods from the viewpoint of eliminating the presence of clots. Methods: In August 2019, we requested the directors of 74 certified facilities to provide information on UCB collection methods in Japan. A total of 46 (62.2%) of them responded with valid information on a total of 2,892 UCB collections. In this study, collected UCB without clots macroscopically was evaluated as a high-quality UCB. Results: The 2,891 UCB collections described during the study period were divided to those with (n = 760, 26.3%) and without clots (high quality; n = 2,131, 73.7%). Multivariate analysis revealed single puncture as a factor determining high-quality UCB collection (adjusted odds ratio (ORs): 1.80, 95% confidence interval (CI): 1.3-5.4, P = 0.01). Conclusions: Single puncture is an independent effective factor determining high-quality manual UCB collection in Japan.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors Associated With Umbilical Cord Blood Collection Quality in Japan

Suzuki

Kimura

Hara³

et al. 2020

J Hematol

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“…Faivre et al examined several variables related to the parturient, pregnancy, labor, delivery, collection, the newborn, the umbilical cord, and the placenta in their comprehensive review that included 71 related articles (26). Maternal age at delivery was assessed in 28 of 71 articles, and it was found not to be associated with favorable CBU collection parameters in most of the studies.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, Faivre et al indicated that iron-related maternal blood variables did not seem to affect the CBU quality according to the literature they reviewed (26). They also evaluated the effect of gestational age at birth by reviewing 24 articles.…”

Section: Discussionmentioning

confidence: 99%

Factors influencing the success of cord blood collection: a tertiary perinatal medicine center’s experience

Yurdakul¹,

Aktoz²,

Örgül³

et al. 2018

Turk J Med Sci

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Background/aim: This study aimed to evaluate the effects of certain maternal, fetal, and umbilical cord blood unit factors on storage and/or discard incidence of collected cord blood units from perinatal medicine patients. Materials and methods: A total of 273 cord blood units collected between January 2011 and December 2016 in the Division of Perinatology of Hacettepe University Hospital were evaluated retrospectively in this study. Results: Of the collected cord blood units, 53.8% (147/273) were stored. Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were statistically significantly different between the eligible and discarded cord blood unit groups (P < 0.001 for all). No cord blood units were discarded owing to contamination-related issues. The mean gestational age for pregnant women whose umbilical cord blood was stored was 36.6 ± 1.0 weeks. Conclusion: Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were significantly different between the eligible and discarded cord blood unit groups. The low rate of specimen storage was most likely because of the unique characteristics of perinatal medicine patients. Physicians should choose appropriate donors for cord blood collection to increase the rate of cord blood utilization.

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Antenatal predictors of stem cell content for successful umbilical cord blood donation

Funk

Buechel

Huhn

et al. 2021

Arch Gynecol Obstet

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Purpose The most important HLA-independent factor for the selection of cord blood units (CBU) for hematopoietic stem cell transplantation is the total nucleated cell (TNC) count over 150 × 107 as a surrogate marker for stem cell content. The purpose of this prospective study was to define prenatal clinical predictors for TNC count that would help to identify successful CBU donors before the onset of active labor. Methods This was a prospective analysis of 594 CBUs, collected from all eligible term singleton pregnancies at Basel University Hospital between 4/2015 and 9/2016 analyzing several maternal and fetal factors. The impact of these factors on TNC count (< 150 × 107 cells vs. ≥ 150 × 107 cells) of the CBUs was modeled in a multivariate analysis. Results A total of 114 (19.2%) CBUs had a TNC count of ≥ 150 × 107. In a ROC analysis there was no significant difference between the AUC of all prenatal factors (AUC 0.62) and estimated fetal birth weight by ultrasound alone (AUC 0.62). For women planning a trial of labor a recruitment cut-off at an estimated birth weight of 3300 g would allow 72.6% of all donors with sufficient TNC count to be recruited and 22.8% of all collected CBUs would have a sufficient TNC count for banking. For women planning for elective CS a cut-off of 3400 g would allow 71.4% of all donors with sufficient TNC count to be recruited and 22.7% of all collected CBUs would have sufficient TNC count for banking. Conclusion The estimated fetal birth weight within 2 weeks of delivery by ultrasound as single parameter can be considered at the time of recruitment to estimate the chances of a successful CBU donation.

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Associated factors of umbilical cord blood collection quality

Cited by 11 publications

References 78 publications

Factors Associated With Umbilical Cord Blood Collection Quality in Japan

Factors Associated With Umbilical Cord Blood Collection Quality in Japan

Factors influencing the success of cord blood collection: a tertiary perinatal medicine center’s experience

Antenatal predictors of stem cell content for successful umbilical cord blood donation

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