Associated risk factors with seroprevalence of HIV and HBV co-infection among Pregnant women attending guelendeng health District in the Mayo-kebbi East Region of Chad

Nguwoh, Salomon Philippe

doi:10.15406/ipcb.2020.06.00215

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…The prevalence of HBsAg found here is lower than that reported in pregnant women attending the Guelendeng health district in the province of Mayo-Kebbi Est in Chad 13% [15]. This difference is probably related to the populations studied.…”

Section: Discussioncontrasting

confidence: 84%

Prevalence of hepatitis B virus and associated factors among pregnant women in the health facilities, N'djamena, Chad

Debsikréo

Mankréo

Ouangkake³

et al. 2023

Preprint

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Background Hepatitis B virus (HBV) infection is a major global health problem. In Chad, the prevalence is estimated at 19% in the overall population. Control hepatitis B among pregnant women may help to break the chain of transmission. However, the prevalence and risk factors of hepatitis B among pregnant women in N'Djamena are not documented. The aim of this study was to establish the HBV prevalence and identify the risk factors associated with hepatitis B in pregnant women in N'Djamena. Methods We conducted a cross-sectional study in eight health facilities in the city of N'Djamena (Chad) from April 4 to August 2, 2021. HBV surface antigen was determined using the SD Bioline HBsAg WB rapid test. We performed a Chi-squared test and an adjusted logistic regression to identify risk factors associated with hepatitis B infection. Results A total of 458 pregnant women were included in the study. The average age of participants was 25 years (95% CI: 20–30). Among risk factors, being older (age > 35 years) and having been tested for HBsAg increase the likelihood of being HBsAg+ (OR = 1.22, 95% CI: 0.33–3.92, p = 0.001, and OR = 4.93, 95% CI: 2.05-12.0, p < 0.001).). Pregnant women whose mothers were AgHBs + were also more likely to be HBsAg+ (OR = 27.8; 95% CI: 4.17–192; P = 0.004). Conclusion The prevalence of hepatitis B shows intermediate endemicity in pregnant women in Chad. Age, HBsAg carrier mother, and history of HBsAg screening are associated with HBV infection.). Thus, to avoid mother to child transmission of HBV, here is a need to improve the health education of pregnant women and the access to routine prenatal screening and vaccination of newborns at birth. It is also important to increase the immunization coverage of the population, through children vaccination campaigns.

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Section: Discussioncontrasting

confidence: 84%

Prevalence of hepatitis B virus and associated factors among pregnant women in the health facilities, N'djamena, Chad

Debsikréo

Mankréo

Ouangkake³

et al. 2023

Preprint

View full text Add to dashboard Cite

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Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa

Torimiro,

Duri,

Goumkwa

et al. 2024

Front. Public Health

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The WHO African Region had 81 million people with chronic hepatitis B in 2019, which remains a silent killer. Hepatitis B virus (HBV), hepatitis delta virus (HDV), and HIV can be transmitted from the mother to child. If the HBV infection is acquired at infancy, it may lead to chronic hepatitis B in 90% of the cases. WHO reports that 6.4 million children under 5 years live with chronic hepatitis B infection worldwide. The prevention of mother-to-child transmission (PMTCT) of HBV is therefore critical in the global elimination strategy of viral hepatitis as we take lessons from PMTCT of HIV programs in Africa. We sought to create a network of multidisciplinary professional and civil society volunteers with the vision to promote cost-effective, country-driven initiatives to prevent the MTCT of HBV in Africa. In 2018, the Mother–Infant Cohort Hepatitis B Network (MICHep B Network) with members from Cameroon, Zimbabwe, and the United Kingdom and later from Chad, Gabon, and Central African Republic was created. The long-term objectives of the network are to organize capacity-building and networking workshops, create awareness among pregnant women, their partners, and the community, promote the operational research on MTCT of HBV, and extend the network activities to other African countries. The Network organized in Cameroon, two “Knowledge, Attitude and Practice” (KAP) surveys, one in-depth interview of 45 health care workers which revealed a high acceptability of the hepatitis B vaccine by families, two in-person workshops in 2018 and 2019, and one virtual in 2021 with over 190 participants, as well as two workshops on grant writing, bioethics, and biostatistics of 30 postgraduate students. Two HBV seroprevalence studies in pregnant women were conducted in Cameroon and Zimbabwe, in which a prevalence of 5.8% and 2.7%, respectively, was reported. The results and recommendations from the MICHep B Network activities could be implemented in countries of the MICHep B Network and beyond, with the goal of providing free birth dose vaccine against hepatitis B in Africa.

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Associated risk factors with seroprevalence of HIV and HBV co-infection among Pregnant women attending guelendeng health District in the Mayo-kebbi East Region of Chad

Cited by 2 publications

References 20 publications

Prevalence of hepatitis B virus and associated factors among pregnant women in the health facilities, N'djamena, Chad

Prevalence of hepatitis B virus and associated factors among pregnant women in the health facilities, N'djamena, Chad

Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa

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