Association among presence of cancer pain, inadequate pain control, and psychotropic drug use

Parás‐Bravo, Paula; Paz-Zulueta, María; Alonso‐Blanco, Cristina; Salvadores-Fuentes, Paloma; Alconero‐Camarero, Ana Rosa; Santibáñez, Miguel

doi:10.1371/journal.pone.0178742

Cited by 6 publications

(4 citation statements)

References 44 publications

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“…On occasion, pharmacological treatments for pain and anxiety can be the same. However, despite the fact that the WHO, the American Cancer Society, and the European Society for Medical Oncology [11,19,20] include the use of psychotropic drugs in their guidelines on the management of oncological pain, consumption of these is not always related with greater pain control in patients with cancer [4].…”

Section: Discussionmentioning

confidence: 99%

“…The Globocan 2018 database reported 18.1 million new cases in the year 2012, estimating that, in 2040, this will increase to 29.5 million new cancer diagnoses worldwide [3]. The complexity of the oncological process, the diagnosis, treatment, secondary effects, and pain, among other aspects, are all associated with greater emotional distress [4].…”

Section: Introductionmentioning

confidence: 99%

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Cancer Patients and Anxiety: A Gender Perspective

Parás‐Bravo

Paz-Zulueta

Boixadera‐Planas

et al. 2020

IJERPH

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The complexity of the diagnosis and treatment of cancer means that it is often associated with anxiety symptoms. The aim of our study was to further our understanding of the oncological process and the presence of anxiety symptoms, from a gender perspective. A cross-sectional study was performed, examining 402 medical records obtained by simple random sampling of oncology patients at a hospital in northern Spain from July 2012 to July 2014. Data collection took place between February and May 2015. Psychiatric and sociodemographic variables were gathered, as well as pain variables and information regarding the oncological process. The data analysis included a descriptive univariate analysis and a bivariate analysis, and a logistic regression model was performed. Our results suggest that women with cancer suffer more anxiety symptoms than men with cancer. Women with anxiety symptoms represented 76.5% of all patients with anxiety. The OR of suffering anxiety symptoms between women and men was 2.43 (95% CI 1.05–5.63) (p = 0.04). A greater incidence of anxiety symptoms was found in patients with cancer pain and oncological treatment with biological therapy. Our results suggest that the gender perspective is necessary in the management of mental health in patients with cancer. Nonetheless, further studies are necessary to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cancer Patients and Anxiety: A Gender Perspective

Parás‐Bravo

Paz-Zulueta

Boixadera‐Planas

et al. 2020

IJERPH

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“…Higher levels of pain were significantly related to psychotropic medication use. Similar studies support this finding with users of psychotropic drugs reporting poor pain control [42,43]. Helstrom and colleagues (2018) found that chronic pain was identified in 14% of 250 older adults who were recently prescribed a psychotropic medication, who also reported pain interference with daily activities [44].…”

Section: Discussionmentioning

confidence: 72%

Psychotropic and Opioid-Based Medication Use among Economically Disadvantaged African-American Older Adults

et al. 2020

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African-American older adults, particularly those who live in economically deprived areas, are less likely to receive pain and psychotropic medications, compared to Whites. This study explored the link between social, behavioral, and health correlates of pain and psychotropic medication use in a sample of economically disadvantaged African-American older adults. This community-based study recruited 740 African-American older adults who were 55+ yeas-old in economically disadvantaged areas of South Los Angeles. Opioid-based and psychotropic medications were the outcome variables. Gender, age, living arrangement, socioeconomic status (educational attainment and financial strain), continuity of medical care, health management organization membership, sleeping disorder/insomnia, arthritis, back pain, pain severity, self-rated health, depressive symptoms, and major chronic conditions were the explanatory variables. Logistic regression was used for data analyses. Arthritis, back pain, severe pain, and poor self-rated health were associated with opioid-based medications. Pain severity and depressive symptoms were correlated with psychotropic medication. Among African-American older adults, arthritis, back pain, poor self-rated health, and severe pain increase the chance of opioid-based and psychotropic medication. Future research should test factors that can reduce inappropriate and appropriate use and prescription of opioid-based and psychotropic medication among economically disadvantaged African-American older adults.

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“…Although the adequacy of analgesic medications has gradually improved over time with the recommendation of the WHO three-step ladder approach, approximately 25% of patients with cancer pain remain undertreated [11,12]. In addition to the complicated and multifactorial mechanisms of cancer pain, the challenges involve both patients' and healthcare professionals' concerns about opioid addiction and the side efects of long-term analgesic treatment [13].…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Brain Stimulation for Cancer Pain Management in Nonbrain Malignancy: A Meta-Analysis

Chien

Chang

et al. 2023

European Journal of Cancer Care

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Purpose. Noninvasive brain stimulation (NIBS) has been reported to have analgesic effects on fibromyalgia and chronic neuropathic pain; however, its effects on cancer pain have yet to be determined. The present study aimed to evaluate the effects of NIBS on patients with pain secondary to nonbrain malignancy. Methods. Electronic databases including PubMed, Embase, Cochrane Library, and Web of Science were searched from inception through June 5th, 2022. Parallel, randomized, placebo-controlled studies were included that enrolled adult patients with cancer pain, except for that caused by brain tumors, compared NIBS with placebo stimulation, and reported sufficient data for performing meta-analysis. Results. Four parallel, randomized, sham-controlled studies were included: two of repetitive transcranial magnetic stimulation (rTMS), one of transcranial direct current stimulation (tDCS), and one of cranial electrical stimulation (CES). rTMS significantly improved pain in the subgroup analysis (standardized mean difference (SMD): −1.148, 95% confidence interval (CI): −1.660 to −0.637, ( p < 0.001 )), while NIBS was not benefited in reducing pain intensity (SMD: −0.632, 95% CI: −1.356 to 0.092, p = 0.087). Also, NIBS significantly improved depressive symptoms (SMD: −0.665, 95% CI: −1.178 to −0.153, p = 0.011), especially in the form of rTMS (SMD: −0.875, 95% CI: −1.356 to −0.395, p < 0.001 ) and tDCS (SMD: −1.082, 95% CI: −1.746 to −0.418, p = 0.001). Conclusion. rTMS significantly improved pain secondary to nonbrain malignancy apart from other forms of NIBS without major adverse events.

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Association among presence of cancer pain, inadequate pain control, and psychotropic drug use

Cited by 6 publications

References 44 publications

Cancer Patients and Anxiety: A Gender Perspective

Cancer Patients and Anxiety: A Gender Perspective

Psychotropic and Opioid-Based Medication Use among Economically Disadvantaged African-American Older Adults

Noninvasive Brain Stimulation for Cancer Pain Management in Nonbrain Malignancy: A Meta-Analysis

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