Association Among SNAP-25 Gene <i>Dde</i>I and <i>Mnl</i>I Polymorphisms and Hemodynamic Changes During Methylphenidate Use

Öner, Özgür; Akın, Ata; Herken, Hasan; Erdal, Mehmet Emin; Çiftçi, Koray; Ay, Mustafa; Biçer, Duygu; Öncü, Bedriye; Bozkurt, Özlem Hekim; Münir, Kerim; Yazgan, Yankı

doi:10.1177/1087054710374597

Cited by 22 publications

(20 citation statements)

References 40 publications

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“…Higher HbO 2 levels and lower HHb levels might be related with neurovascular coupling and increased blood flow with HHb levels from activated brain region. Individual T homozygous in both SNPs did not increase HHb in right prefrontal, suggesting genotypes differently affect neurovascular coupling [Öner et al, ]. It is difficult to compare this study with other previous studies because they did not evaluate symptomatic response and comorbidity as well as did not split groups between responders or non‐responders.…”

Section: Resultsmentioning

confidence: 85%

ADHD pharmacogenetics across the life cycle: New findings and perspectives

Bruxel

Akutagava-Martins

Salatino-Oliveira

et al. 2014

American J of Med Genetics Pt B

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Attention-deficit/hyperactivity disorder (ADHD) is a complex and heterogeneous disorder, affecting individuals across the life cycle. Although its etiology is not yet completely understood, genetics plays a substantial role. Pharmacological treatment is considered effective and safe for children and adults, but there is considerable inter-individual variability among patients regarding response to medication, required doses, and adverse events. We present here a systematic review of the literature on ADHD pharmacogenetics to provide a critical discussion of the existent findings, new approaches, limitations, and recommendations for future research. Our main findings are: first, the number of studies continues to grow, making ADHD one of the mental health areas with more pharmacogenetic studies. Second, there has been a focus shift on ADHD pharmacogenetic studies in the last years. There is an increasing number of studies assessing gene-gene and gene-environment interactions, using genomewide association approaches, neuroimaging, and assessing pharmacokinetic properties. Third and most importantly, the heterogeneity in methodological strategies employed by different studies remains impressive. The question whether pharmacogenetics studies of ADHD will improve clinical management by shifting from trial-and-error approach to a pharmacological regimen that takes into account the individual variability remains unanswered.

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Section: Resultsmentioning

confidence: 85%

ADHD pharmacogenetics across the life cycle: New findings and perspectives

Bruxel

Akutagava-Martins

Salatino-Oliveira

et al. 2014

American J of Med Genetics Pt B

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“…Changes in brain activation levels using fNIRS have been found to differentiate known clinical groups from typically developing children (Ishii-Takahashi et al, 2014, Wiley et al, 2014) and to be related to parent-reported measures of behavioral functioning (Perlman et al, 2014). Changes in activation obtained from fNIRS have already been used to assess the impact of pharmacological interventions for children with Attention Deficit-Hyperactivity Disorder (ADHD) (Oner et al, 2011, Schecklmann et al, 2011, Monden et al, 2012, Matsuura et al, 2014, Araki et al, 2015) but have not yet been applied to understanding individual differences in children with FASDs.…”

Section: Introductionmentioning

confidence: 99%

Prefrontal cortical responses in children with prenatal alcohol-related neurodevelopmental impairment: A functional near-infrared spectroscopy study

Kable

Coles

2017

Clinical Neurophysiology

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Objective Disruption in the neural activation of the prefrontal cortex (PFC) in modulating arousal was explored in children with heavy prenatal alcohol exposure (PAE), who have known neurobehavioral impairment. Methods During a task that elicits frustration, functional near-infrared spectroscopy (fNIRS) was used to measure PFC activation, specifically levels of oxygenated (HBO) and deoxygenated (HBR) hemoglobin, in children with PAE (n=18) relative to typically developing Controls (n=12) and a Clinical Contrast group with other neurodevelopmental or behavioral problems (n=14). Results Children with PAE had less activation during conditions with positive emotional arousal, as indicated by lower levels of HBO in the medial areas of the PFC and higher levels of HBR in all areas of the PFC sampled relative to both other groups. Children in the Control group demonstrated greater differentiation of PFC activity than did children with PAE. Children in the Clinical Contrast group demonstrated the greatest differences in PFC activity between valences of task conditions. Conclusions: Specific patterns of PFC activation differentiated children with PAE from typically developing children and children with other clinical problems. Significance FNIRS assessments of PFC activity provide new insights regarding the mechanisms of commonly seen neurobehavioral dysfunction in children with PAE.

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“…58 The polymorphism of synaptosomal-associated protein 25 gene was associated with methylphenidate-related HbO and HbR changes in ADHD patients. 59 The go/no-go task produced signi¯cant di®erentiable changes between the HbO levels in the PFCs of healthy and ADHD patients while the Stroop task did not. 35 Compared to the Stroop task, the reverse Stroop task showed signi¯cant di®erentiable HbO responses among healthy, ASD, and ADHD children in the right lateral PFC.…”

Section: Stroop Taskmentioning

confidence: 99%

Application of functional near-infrared spectroscopy in the healthcare industry: A review

Hong

Yaqub

2019

J. Innov. Opt. Health Sci.

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Functional near-infrared spectroscopy (fNIRS), a growing neuroimaging modality, has been utilized over the past few decades to understand the neuronal behavior in the brain. The technique has been used to assess the brain hemodynamics of impaired cohorts as well as able-bodied. Neuroimaging is a critical technique for patients with impaired cognitive or motor behaviors. The portable nature of the fNIRS system is suitable for frequent monitoring of the patients who exhibit impaired brain activity. This study comprehensively reviews brain-impaired patients: The studies involving patient populations and the diseases discussed in more than 10 works are included. Eleven diseases examined in this paper include autism spectrum disorder, attention-deficit hyperactivity disorder, epilepsy, depressive disorders, anxiety and panic disorder, schizophrenia, mild cognitive impairment, Alzheimer’s disease, Parkinson’s disease, stroke, and traumatic brain injury. For each disease, the tasks used for examination, fNIRS variables, and significant findings on the impairment are discussed. The channel configurations and the regions of interest are also outlined. Detecting the occurrence of symptoms at an earlier stage is vital for better rehabilitation and faster recovery. This paper illustrates the usability of fNIRS for early detection of impairment and the usefulness in monitoring the rehabilitation process. Finally, the limitations of the current fNIRS systems (i.e., nonexistence of a standard method and the lack of well-established features for classification) and future research directions are discussed. The authors hope that the findings in this paper would lead to advanced breakthrough discoveries in the fNIRS field in the future.

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Association Among SNAP-25 Gene DdeI and MnlI Polymorphisms and Hemodynamic Changes During Methylphenidate Use

Cited by 22 publications

References 40 publications

ADHD pharmacogenetics across the life cycle: New findings and perspectives

ADHD pharmacogenetics across the life cycle: New findings and perspectives

Prefrontal cortical responses in children with prenatal alcohol-related neurodevelopmental impairment: A functional near-infrared spectroscopy study

Application of functional near-infrared spectroscopy in the healthcare industry: A review

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