Association among the Presence of Rotavirus Group A and Types of Sources Located in Rural Communities

Gonçalves, Lucas Cândido; Lima, Fernando Santos; Silva, Paulo Alex Neves da; Bordoni, Graziela Picciola; Scalize, Paulo Sérgio; Vieira, José Daniel Gonçalves; Carneiro, Lí­lian Carla

doi:10.3390/w15091763

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Recently, a growing number of studies show an association between T2DM and infection the opportunistic pathogen Klebsiella pneumoniae (Kp) [15][16][17][18], yet the mechanistic connection between these diseases remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

Type-2 diabetes mellitus enhancesKlebsiella pneumoniaepathogenesis

Todd,

Gunter,

Bowen

et al. 2024

Preprint

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Klebsiella pneumoniaeis an opportunistic pathogen and an important cause of pneumonia, bacteremia, and urinary tract infection.K. pneumoniaeinfections are historically associated with diabetes mellitus. There is a fundamental gap in our understanding of how diabetes mellitus, specifically type 2 diabetes, influencesK. pneumoniaepathogenesis.K. pneumoniaepathogenesis is a multifactorial process that often begins with gut colonization, followed by an escape from the gut to peripheral sites, leading to host damage and infection. We hypothesized that type 2 diabetes enhancesK. pneumoniaepathogenesis. To test this, we used well-established mouse models ofK. pneumoniaecolonization and lung infection in conjunction with a mouse model of spontaneous type 2 diabetes mellitus (T2DM). We show that T2DM enhances susceptibility to bothK. pneumoniaecolonization and infection. The enhancement of gut colonization is dependent on T2DM-induced modulation of the gut microbiota community structure. In contrast, lung infection is exacerbated by the increased availability of amino acids in the lung, which is associated with higher levels of vascular endothelial growth factor. These data lay the foundation for mechanistic interrogation of the relationship betweenK. pneumoniaepathogenesis and type 2 diabetes mellitus, and explicitly establish T2DM as a risk factor forK. pneumoniaedisease.

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Section: Introductionmentioning

confidence: 99%

Type-2 diabetes mellitus enhancesKlebsiella pneumoniaepathogenesis

Todd,

Gunter,

Bowen

et al. 2024

Preprint

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“…Klebsiella pneumoniae are Gram-negative bacteria found ubiquitously in natural and manmade environments [1][2][3]. In immunocompromised patients, and those with co-morbidities such as diabetes or alcoholism, K. pneumoniae can colonize multiple body sites causing a diverse array of infections ranging from life-threatening pneumonia, urinary tract infections (UTIs), and bacteremia [4][5][6][7][8]. K. pneumoniae is a frequently reported multidrug-resistant (MDR) pathogen isolated from nosocomial settings.…”

Section: Introductionmentioning

confidence: 99%

Transposon mutagenesis screen inKlebsiella pneumoniaeidentifies genetic determinants required for growth in human urine and serum

Gray

Torres

Goodall

et al. 2023

Preprint

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Klebsiella pneumoniae is a global public health concern due to the rising myriad of hypervirulent and multi-drug resistant clones both alarmingly associated with high mortality. The molecular microbial genetics underpinning these recalcitrant K. pneumoniae infections is unclear, coupled with the emergence of lineages resistant to nearly all present day clinically important antimicrobials. In this study, we performed a genome-wide screen in K. pneumoniae ECL8, a member of the endemic K2-ST375 pathotype most often reported in Asia, to define genes essential for growth in a nutrient-rich laboratory medium (Luria-Bertani medium), human urine and serum. Through transposon directed insertion-site sequencing (TraDIS), a total of 427 genes were identified as essential for growth on LB agar, whereas transposon insertions in 11 and 144 genes decreased fitness for growth in either urine or serum, respectively. Genome-wide functional studies like these provide further knowledge on the genetics of this pathogen but also provide a strong impetus for discovering new antimicrobial targets to improve current therapeutic options for K. pneumoniae infections.

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Rotavirus in Water Environments: A Systematic Review and Meta-Analysis

Awere-Duodu,

Donkor

2024

Environ�Health�Insights

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Background: Despite the adoption of rotavirus vaccines, sporadic outbreaks of the virus have been reported in many parts of the world. These outbreaks are facilitated by several factors including the ease of transmission of rotavirus through water environments. This systematic review aimed to determine the global prevalence of rotavirus in water environments. Methodology: Comprehensive Boolean searches were conducted in PubMed, SCOPUS, and Web of Science. A total of 75 eligible studies were included in the study, from which data was extracted for both systematic review and meta-analysis. Extracted prevalence data was grouped according to six water categories: drinking water, untreated sewage, treated sewage, surface water, groundwater, and others. A single-group prevalence meta-analysis was conducted in RStudio version 4.3.3 subjecting the data to the random-effects model. Results: The included studies were conducted in 32 countries that span 5 continents: Africa, Asia, Europe, North America, and South America. The pooled prevalence of rotavirus in water environments was 40.86%. Among the individual water environments, untreated sewage had the highest prevalence (68.27%), followed by treated sewage (53.07%), surface water (33.40%), groundwater (25.64%) and drinking water (9.46%). Continental stratification of the prevalence data was as follows: Africa (51.75%), Asia (32.48%), Europe (55.90%), North America (41.80%), and South America (28.51%). Conclusion: There is a high prevalence of rotavirus in water environments, especially in untreated sewage, and in Europe. Further research is needed to find more efficient methods that can effectively eliminate rotavirus to insignificant levels in water environments.

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Association among the Presence of Rotavirus Group A and Types of Sources Located in Rural Communities

Cited by 3 publications

References 51 publications

Type-2 diabetes mellitus enhancesKlebsiella pneumoniaepathogenesis

Type-2 diabetes mellitus enhancesKlebsiella pneumoniaepathogenesis

Transposon mutagenesis screen inKlebsiella pneumoniaeidentifies genetic determinants required for growth in human urine and serum

Rotavirus in Water Environments: A Systematic Review and Meta-Analysis

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