Association analysis between the −2518MCP‐1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population

Abstract

The polymorphisms of -2518MCP-1 may play an important role in determining generalized aggressive periodontitis susceptibility in this cohort of Chinese women.

Association between monocyte chemoattractant protein-1 -2518 A/G gene polymorphism and the outcome of the nonsurgical periodontal treatment

“…14,25 The G allele frequency of MCP-1 -2518 A/G in our study was similar to other studies in Asian groups (42.5e66%), 17,26,27 but it was different with Caucasian, AfricaneAmerican and Hispanic groups (22e30%). 14,28,29 Our study reported that 42.5% of Taiwanese had allele G at MCP-1 -2518 and revealed there are different distributions of MCP-1 gene polymorphism among various ethnic groups which was consistent with the findings of IL-1 gene polymorphism.…”

“…The frequency of MCP-1 -2518 G genotype has been shown to be significantly lower in female patients with aggressive periodontitis compared to the female healthy group. 17 On the other hand, they found aggressive periodontitis female patients with MCP-1 -2518 A/A genotype had deeper probing depth than patients with MCP-1 -2518 A/G and G/G genotype. Moreover, confounding factors such as smoking habits, age, baseline parameters in the periodontal treatment can be important considerations for dentists to predict the outcomes of periodontal treatments.…”

“…15,16 However, a study by Zhu et al revealed that Chinese women with generalized aggressive periodontitis had lower frequency of MCP-1 -2518 A/G gene polymorphism than healthy female group (71.2% vs. 85.7%). 17 Their another research further studied combined effect of CCR2-V64I and MCP-1 -2518 A/G on aggressive periodontitis patients. They found the odds ratio for VV genotype (CCR2) and smoking, or MCP-1 (G genotype) and smoking were 7.4 and 4.9, respectively in male patients with periodontitis.…”

GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis

“…The incidences in different areas and different races are different, which may be influenced by ethnic differences of gene polymorphisms [30]. Lots of studies have investigated the importance of genetic polymorphisms (e.g., MCP-1, S100A8, IL-1 α , IL-1 β , and N-formyl peptide receptor) in aggressive periodontitis [31–34]. To the best knowledge of the authors, there are only two studies that have investigated the association between GC gene and periodontitis.…”

Gingival crevicular fluid levels of monocyte chemoattractant protein‐1 in patients with aggressive periodontitis

“…Monocyte chemoattractant protein (MCP)‐1 is a CC chemokine (Melgarejo et al , ) that attracts monocytes to inflammatory areas and plays a crucial role in inflammatory response, both in acute and chronic inflammatory conditions (Samaan et al , ; O'Connor et al , ). Relatedly, MCP‐1 has been observed in a variety of tissues during inflammation‐associated disease progression, and likewise, periodontitis patients have exhibited high levels of MCP‐1 in GCF (Lee et al , ; Emingil et al , ; Kurtis et al , ; Pradeep et al , ; Thunell et al , ; Tymkiw et al , ; Gupta et al , ), in gingival tissue (Yu et al , ; Yu and Graves, ; Gemmell et al , ; Garlet et al , ), and in sera/plasma (Pradeep et al , ; Zhu et al , ; Anil et al , ; Gupta et al , ) compared with periodontally healthy (H) subjects. In addition to these results, correlation between GCF MCP‐1 and clinical parameters as attachment loss suggests that MCP‐1 plays an important role in the attraction of monocytes and in the enhancement of inflammatory signals in periodontitis pathogenesis (Zhu et al , ).…”