Association Analysis of 2 Subunit of -Aminobutyric Acid Type- A Receptor (Gabrg2) and Leucine-Rich Glioma-Inactivated 4 Gene (Lgi-4) Polymorphisms With Idiopathic Epilepsies and Febrile Seizures

Abstract

BACKGROUND Epilepsy is the most common neurological disorder affecting 60 million people worldwide and in an estimated 40% of whom it is genetically determined. Idiopathic epilepsies are those in which genetic aetiology is likely or proven. An alteration of GABA-ergic neurotransmission has been implicated as an aetiologic factor in epileptogenesis, while LGI-4 (Leucine Rich Glioma Inactivated 4) is not homologous to any known ion channel and the mechanism by which it causes epilepsy is unknown. LGI-4 belongs to a super family LRR (Leucine Rich Repeats) proteins and suspected to have a role in peripheral nerve myelination. The authors aimed to determine whether genetic variations in the GABRG2 and LGI-4 gene confers susceptibility to idiopathic epilepsy and febrile seizures or not. MATERIALS AND METHODS In this case control study, samples of 30 cases and 42 controls were taken. Allelic frequencies were expressed as a percentage of the total number of alleles. Genotypes and allelic frequencies for c.588C/T in fifth exon of gene GABRG2 (SNP211037, Asn196Asn) and c.1914GC/AT located in ninth exon of the gene LGI-4 were compared in both groups. RESULTS Association analysis of GABRG-2 polymorphism between CC, CT and TT genotypes statistically showed insignificant result as χ 2 value was 0.12 and p value was > 0.05. Association analysis of LGI-4 polymorphism between GC/GC, GC/AT and AT/AT genotypes statistically showed insignificant result as χ 2 value was 0.51 and p value was > 0.05. CONCLUSION It was concluded that GABRG2 and LGI-4 polymorphisms were not the susceptibility factors for idiopathic epilepsies and febrile seizures. KEY WORDS γ-Aminobutyric Acid Type A Receptor (GABRG2) Polymorphism, Leucine-Rich Glioma-Inactivated 4 Gene (LGI-4) Polymorphism, Idiopathic Epilepsies and Febrile Seizures. HOW TO CITE THIS ARTICLE: Gupta G, Kumar N, Chandra R. Association analysis of γ2 subunit of γ-aminobutyric acid type-a receptor (GABRG2) and leucine-rich glioma-inactivated 4 gene (LGI-4) polymorphisms with idiopathic epilepsies and febrile seizures.