Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations

Abstract

SOD2 (superoxide dismutase 2) plays a crucial role in protecting the cells against damage caused by free radicals, by catalyzing their detoxification. On the other hand, cell damage caused by free radical generation following methamphetamine administration has been postulated as one of the possible pathophysiological mechanisms for methamphetamine psychosis. Hence, we investigated the association of SOD2 polymorphisms with the development of methamphetamine psychosis, in two independent populations of Japan and Taiwan. We recruited 116 patients with methamphetamine psychosis and 189 controls in Japan, and 135 patients with methamphetamine psychosis and 204 controls in Taiwan. The methamphetamine group was divided into two clinical subtypes: a transient type of psychosis (i.e., good prognosis) and a prolonged type of psychosis (i.e., poor prognosis), according to the course of the manifestation of psychosis. With reference to the genotypic and allelic frequencies of Ala/Val functional polymorphism in exon 2, we found significant differences between individuals with prolonged methamphetamine psychosis and control samples from Japan and Taiwan in the genotypic (P value 0.014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis.

Ala16Val SOD2 polymorphism is associated with higher pregnancy rates in in vitro fertilization cycles

“…These results are in agreement with other studies on white populations, where the Ala/Val genotype predominates (20,24). In contrast, in Asian populations the Val/Val genotype is the most frequent (80%), the Ala/Ala representing less than 5% (25). We found that the Ala/Ala SOD2 genotype significantly influences the pregnancy outcome in IVF.…”

Evaluation of Genetic Polymorphisms in Patients with Multiple Chemical Sensitivity

“…The study sample size had at least 80% power (two-sided test significant, α of 0.05) to detect an OR of at least 2.5, following the calculations used in previous studies [9,14,16,25–27]. The distribution of each genetic variant in the cases and controls was first assessed for consistency with the Hardy-Weinberg equilibrium (HWE) on a contingency table of observed-versus-predicted genotype frequencies by using Chi-Square Goodness of Fit test.…”

Genetic Factors Modulating the Response to Stimulant Drugs in Humans

“…These studies mostly focus on methamphetamine abuse-related phenotypes. These genes include CES1 (Nemoda et al 2009); DTNBP1 (Kishimoto et al 2008a); FZD3 (Kishimoto et al 2008b); G72 (Kotaka et al 2009); GABRG2 (Nishiyama et al 2005); GLYT1 (Morita et al 2008); GRM2 (Tsunoka et al 2010); GSTM1 (Nakatome et al 2009); GSTP1 (Hashimoto et al 2004); GSTT1 (Nakatome et al 2009); NQO2 (Ohgake et al 2005); PDYN (Nomura et al 2006); PICK1 (Matsuzawa et al 2007); PROKR2 (Kishi et al 2010); SLC22A3 (Aoyama et al 2006); SNCA (Kobayashi et al 2004) and SOD2 (Nakamura et al 2006). …”