Association and differential role of PRSS1 and SPINK1 mutation in early-onset and late-onset idiopathic chronic pancreatitis in Chinese subjects

Incidence of Pancreatic Cancer in Chinese Patients with Chronic Pancreatitis

“…In our series, 3 of 4 pancreatic cancer patients had nonalcoholic CP and half of them were nonsmokers. Since Chinese pancreatic cancer patients may have different K-ras and p53 expressions, and Chinese CP patients have different PRSS1 and SPINK1 mutations than other populations [40,41], it seems reasonable to speculate that genetic factors are likely to play an different role in the causes of CP and the development to pancreatic cancer in the Chinese population. Further investigations focusing on genetic factors and/or their interaction with environmental risk factors are needed.…”

Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis

“…The same variant was later identified in a subject of Chinese origin with idiopathic chronic pancreatitis (6). The limited clinical and genetic data do not allow conclusive determination whether or not the p.L104P variant is pathogenic.…”

Asian chronic pancreatitis: The common and the unique

“…7 In addition, genetic susceptibility for developing CP-like serine protease inhibitor Kazal type I (SPINK1) and protease serine 1 (PRSS1) mutations have been reported differently in different regions. 8,9 Unlike the West where both mutations are related to hereditary and chronic pancreatitis, in Asia only SPINK1 mutation has been reported to be as strongly related to TP. 10,11 The loss of protease inhibitor SPINK1 phenotype results in sustained "super-trypsin" activity that leads to susceptibility of pancreas to autolysis.…”

“…32 Typically, steroids are very effective in treating AIP. However, about one quarter of patients develop a relapse and Bimodal presentation on age Pancreatic type pain in both groups 10 Male predominant For both alcoholic CP and TP 7,8 Pancreatic duct calculi with multiple duct strictures…”

“…True for TP, alcoholic, and idiopathic pancreatitis 6,8 CP, chronic pancreatitis; TP, tropical pancreatitis. Asian CP: The common and the unique R Rerknimitr they may require long-term immunosuppressive therapy with azathioprine.…”