Association and Familial Coaggregation of Type 1 Diabetes and Eating Disorders: A Register-Based Cohort Study in Denmark and Sweden

Tate, Ashley; Liu, Shengxin; Zhang, Ruyue; Yılmaz, Zeynep; Larsen, Janne Tidselbak; Petersen, Liselotte; Bulik, Cynthia M.; Svensson, Ann‐Marie; Guðbjörnsdóttir, Soffia; Larsson, Henrik; Butwicka, Agnieszka; Kuja‐Halkola, Ralf

doi:10.2337/dc20-2989

Cited by 12 publications

(12 citation statements)

References 41 publications

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“…This is especially relevant as binge-eating behaviours have been shown to worsen metabolic markers, including glycemic control 127 . Type 1 diabetes (T1D) as well as other autoimmune associated disorders were also more common in individuals with BED than referent controls 128 . In two pilot studies, 23% 129 to 28% 130 of people with nonalcoholic fatty liver disease (NAFLD) screened positive for BED, with this pattern of comorbidity probably arising from shared risk factors including obesity, insulin resistance, metabolic syndrome, and an unfavourable body composition 130 .…”

Section: [H2] Medical Morbidity and Complications In Bedmentioning

confidence: 99%

Binge eating disorder

Giel¹,

Bulik

Fernández‐Aranda

et al. 2022

Nat Rev Dis Primers

121

101

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Primer articlesNature Reviews publishes timely, authoritative articles that are of broad interest and exceptional quality. Thank you for taking the time to help us to ensure that our articles meet these high standards.Primer articles in Nature Reviews provide an overview of a disease or disorder. Primers are intended to provide an authoritative, global perspective for the benefit of biomedical scientists, putting current clinical and translational challenges into context. These overview articles are meant to be introductory and cover all aspects from epidemiology to disease mechanisms, diagnosis and treatment.Please submit your report in narrative form and provide detailed justifications for all statements. Confidential comments to the editor are welcome, but it is helpful if the main points are stated in the comments for transmission to the authors.Please note that all Primer articles follow the same set organization of the main headings. Additionally, Nature Reviews articles will be thoroughly edited before publication and all figures will be redrawn by our in-house art editors. We therefore request that you concentrate on the scientific content of the article and display items, rather than the 'order' of the content or any minor errors in language or grammar that might be present in the draft version. Please consider and comment on the following points when reviewing this manuscript:• Is the article written for a broad audience, including biomedical scientists, translational researchers, medical students and clinicians?• Is the global perspective well represented?• Does the article present the current state of the art in the disease, without much emphasis on historical aspects?• Are the open research questions outlines and comprehensive?• Does the length of the article seem appropriate?• Are the ideas logically presented and discussed?• Does the article provide a balanced overview of the literature? Please bear in mind that it may not be possible to cover all aspects of a field within such a concise article.• Is the discussion fair and accurate? Although our authors are encouraged to be opinionated, they should not ignore alternative points of view. • Do the figures, boxes and tables provide clear and accurate information? Are there any additional or alternative display items that you think that the authors should include?• Are the references appropriate and up-to-date? Do they reflect the scope of the article?• Are you aware of any undeclared conflicts of interest that might affect the balance, or perceived balance, of the article?

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Section: [H2] Medical Morbidity and Complications In Bedmentioning

confidence: 99%

Binge eating disorder

Giel¹,

Bulik

Fernández‐Aranda

et al. 2022

Nat Rev Dis Primers

121

101

View full text Add to dashboard Cite

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“…According to Larrañaga [72], the risk of disordered eating is greater in patients with T1DM compared to the general population due to multiple interacting factors related to DM and its treatment [19,20]. On the other hand, a recent meta-analysis [73] revealed that EDs are highly prevalent in T2DM, as both BED and BN appeared to increase the risk of T2DM.…”

Section: Characteristics Of Patients With Dm and On Tendenciesmentioning

confidence: 99%

“…According to a Danish and Swedish cohort study of more than 4,300,000 individuals [20], patients with T1DM exhibited a greater risk of having an ED diagnosis. Similar findings have also been confirmed in other populations [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Obsessed with Healthy Eating: A Systematic Review of Observational Studies Assessing Orthorexia Nervosa in Patients with Diabetes Mellitus

et al. 2021

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Orthorexia nervosa (ON) is an unspecified feeding or eating disorder (USFED) characterized by an exaggerated, unhealthy obsession with healthy eating. Τypical eating disorders (EDs) and USFEDs are common among patients with diabetes mellitus (DM), which complicates metabolic control and disease outcomes. The present systematic review summarizes the evidence on the prevalence of ON symptomatology among patients with DM. PubMed, Web of Science, Scopus, and grey literature were searched, and relevant observational studies were screened using the Rayyan software. The quality of the studies was assessed using the appraisal tool for cross-sectional studies (AXIS) and the Newcastle–Ottawa scale (NOS). Out of 4642 studies, 6 fulfilled the predefined criteria and were included in the qualitative synthesis. Most studies relied on the ORTO-15 or its adaptations to identify ON among patients with DM. No apparent sex or age differences exist regarding the prevalence of ON symptoms. None of the studies compared the prevalence of ON in patients with type 1 and type 2 DM. Most of the research was of average to good methodological quality. In conclusion, patients with DM often exhibit ON tendencies, although research is still limited regarding the etiology or mechanistic drivers behind ON and the characteristics of patients with a dual ON–DM diagnosis.

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“…Type 1 diabetes is a chronic auto-immune disease characterized by deterioration of insulin-producing beta cells in the pancreas, leading to insulin depletion and hyperglycemia [1]. Individuals with type 1 diabetes have a 2-threefold increased risk of disordered eating (DE) or eating disorders (ED) [2][3][4][5][6][7]. Coexisting type 1 diabetes and DE/ED is associated with impaired metabolic control and consequently an increased morbidity and mortality [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Patients’ perspectives on screening for disordered eating among adolescents with type 1 diabetes

et al. 2023

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Purpose People with type 1 diabetes have an increased risk of disordered eating (DE) and eating disorders (ED). Screening is recommended however little is known about patients’ perspectives on screening questionnaires. This paper reports qualitative analyses of patients’ perspectives on the questionnaire Diabetes Eating Problem Survey Revised (DEPS-R), including acceptability, attitudes, and cognitive understanding. Research design and methods 15 adolescents with type 1 diabetes between 11 and 18 years, were interviewed. A semi-structured format and a qualitative Interpretive Descriptive (ID) methodology was chosen. Results The analyses identified four themes: (1) The Questionnaire, (2) Reframing Diabetes Visits, (3) This is (not) for me, and (4) Out in the Open. The DEPS-R was completed with-in 5–10 min. with no technical difficulties. The questionnaire altered the diabetes visit for some, creating a new dialog, and time for self-reflection. Adolescents appreciated the direct approach in the questionnaire, and showed willingness to complete the questionnaire, when presented to them by a health care professional (HCP). One item in the DEPS-R proved difficult to understand for some participants. Conclusion The study highlights DEPS-R as a clinically relevant screening questionnaire. Completing DEPS-R prior to a consultation opens the door to a consultation that invites the adolescent to address matters of eating behavior. Our findings suggest that systematic screening of DE/ED using the DEPS-R is both accepted and welcomed by adolescents with type 1 diabetes. Future research should focus on a potential update of selected items in DEPS-R. Level of evidence V – qualitative study.

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Association and Familial Coaggregation of Type 1 Diabetes and Eating Disorders: A Register-Based Cohort Study in Denmark and Sweden

Cited by 12 publications

References 41 publications

Binge eating disorder

Binge eating disorder

Obsessed with Healthy Eating: A Systematic Review of Observational Studies Assessing Orthorexia Nervosa in Patients with Diabetes Mellitus

Patients’ perspectives on screening for disordered eating among adolescents with type 1 diabetes

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