Association and interaction between model for end‑stage liver disease score and minimally invasive treatment with regard to mortality of patients with hepatitis B virus‑associated hepatocellular carcinoma and portal vein tumor thrombi

Abstract

The development of minimally invasive treatment over the last two decades has had a great impact on hepatitis B virus (HBV)-associated primary liver cancer. The model for end-stage liver disease (MELD) score is the optimal evaluated parameter for mortality in patients with end-stage liver disease. However, the association between MELD score and minimally invasive treatment with regard to the mortality of patients with HBV-associated hepatocellular carcinoma (HCC) with a portal vein tumor thrombus (PVTT) remains unclear. In the present study, a total of 173 patients who had been diagnosed with HBV-associated HCC and PVTT in the Beijing Ditan Hospital (Beijing, China), between January 2012 and January 2015, were screened. Follow-up was performed to observe the survival time and collect information on the demographic characteristics and associated clinical indicators present in the cohort. The patient's age, sex, laboratory parameters and the use of minimally invasive treatment were analyzed with SPSS 20.0 software. Independent risk factors for mortality were screened by Cox regression analysis. Logistic regression indicated that there was an interaction between the MELD score and minimally invasive treatment. In addition, a MELD score ≤17.85 was associated with a lower mortality rate subsequent to minimally invasive treatment.

Primary non-response to antiviral therapy affects the prognosis of hepatitis B virus-related hepatocellular carcinoma

“…The independent risk factors for 1-year OS in HBV-related HCC with high HBV-DNA levels were HGB level < 120 g/L, no-PR, PVTT, tumor size ≥ 5 cm, and tumor multiplicity. Known independent prognostic factors for death in HBV-related HCC include PVTT, tumor size, tumor number, HBV DNA, AST, and Child–Pugh score [ 38 , 39 ]. Previous studies have also demonstrated that patients with anemia have increased risk of death compared to those without anemia [ 40 , 41 ].…”