Association and interaction of genetic variants with occurrence of ischemic stroke among Brazilian patients

LncRNAs Stand as Potent Biomarkers and Therapeutic Targets for Stroke

“…Genomics has illuminated particular genetic variants that are correlated with stroke pathology (Ferreira et al, 2019). Variants present in 35 genetic loci have been associated with a higher risk of stroke (Dichgans et al, 2019).…”

“…Variants present in 35 genetic loci have been associated with a higher risk of stroke (Dichgans et al, 2019). However, ischemic stroke does display genetic heterogeneity, as various populations exhibit different genetic variants (Ferreira et al, 2019). Therefore, although evidence has pointed to lncRNA as a promising therapeutic strategy and diagnostic marker for stroke, disparities among individuals must be taken into account due to genotype heterogeneity.…”

New findings in the roles of Cyclin-dependent Kinase inhibitors 2B Antisense RNA 1 ( CDKN2B-AS1 ) rs1333049 G/C and rs4977574 A/G variants on the risk to coronary heart disease

“…Polymorphisms of CDKN2B-AS1 have been investigated previously and have been correlated with susceptibility to various diseases that include ischemic stroke, glaucoma, gout, and cancer [9][10][11][12]. Prior studies have assessed the potential association between CDKN2B-AS1 variants and the likelihood of CHD.…”

Norberto Cabral: A Pioneer in Stroke Research in Brazil Leaves a Huge Legacy for Latin America

“…

well as a researcher and clinical neurologist at the Hospital Municipal São José and Neurological Clinic in Joinville.As one of the most distinguished Brazilian stroke researchers, he started the JOINVASC in 2005, a population-based registry in the city of Joinville, one of the largest stroke databases in the world, providing information to plan the stroke assistance in his city, and also establishing important knowledge about stroke [1][2][3][4][5][6][7][8][9][10][11].With his persistence, leadership and expertise, he put Joinville on the Brazilian and world map, showing the work of his group in the first stroke unit created in Brazil (1997) [1]. He always followed what he preached: "who has numbers has argument, who has information has power."

…”

“…As one of the most distinguished Brazilian stroke researchers, he started the JOINVASC in 2005, a population-based registry in the city of Joinville, one of the largest stroke databases in the world, providing information to plan the stroke assistance in his city, and also establishing important knowledge about stroke [1][2][3][4][5][6][7][8][9][10][11].…”