Association and Prognostic Implication of C-Reactive Protein with Risk of 1-Year Death or Disabling Stroke After Transcatheter Aortic Valve Replacement

Prognostic impact of baseline C‐reactive protein levels on mortality after transcatheter aortic valve implantation

“…Our search identified 14 eligible studies [13][14][15][16][17][18][19][20][21][22][23][24][25][26] including a total of 3449 patients undergoing TAVI (Table 1) and reporting early (in-hospital, 15 30-day, 17,19,23 and 3-month 20 ) and midterm (1-year, [14][15][16][17]22,25,26 600day, 13 2-year, 18,20 and 3-year 21,24 ) all-cause mortality after TAVI (Table 2). Hioki et al 20 reported data on both CRP and high-sensitive CRP (hs-CRP) form the Optimized Transcatheter Valvular Intervention (OCEAN)-TAVI registry, and we extracted the former.…”

“…18,[20][21][22]26 We converted ORs/HRs of mortality per SD (or unit) increase in CRP levels to those for high vs low CRP levels in six studies, [21][22][23][24][25][26] and vice versa in three studies. 17,19,20 In three studies, [13][14][15] SMDs in CRP levels between nonsurvivors and survivors were converted to ORs of mortality for high vs low CRP levels, from which ORs of mortality per SD increase in CRP levels were further calculated.…”

“…A number of sensitivity analyses for midterm mortality were performed. Excluding HRs for hs-CRP 21,25 (Figure S1), combining ORs/HRs of 1-year mortality [14][15][16][17]22,25,26 (Figure S2), pooling HRs of ≥2-year mortality 18,20,21,24 (Figure S3), and combining adjusted HRs 18,[20][21][22]26 (Figure S4) did not alter the primary results.…”

C-reactive Protein to Albumin Ratio as A Novel Inflammatory Biomarker for Postoperative Delirium in Patients Undergoing Transcatheter Aortic Valve Replacement

“…CRP, one of the most common markers for systemic inflammation, has been linked with increased cardiovascular and all cause mortality following TAVR (25,26). In addition, although there are conflicting data, the previous literature sought to examine the relationship between pre-and postoperative elevated CRP levels and the development of POD in patients undergoing cardiac and noncardiac surgery (2,27,28).…”

C-Reactive Protein to Albumin Ratio as A Novel Inflammatory-Based Marker for 30-Day Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement

“…Although various aetiological risk factors for degenerative AS have been identified, it has been described as an inflammatory-based disease that shares common pathophysiology with atherosclerosis, including calcification, accumulation of lipoproteins and chronic inflammation [ 2 ] . Because AS is the result of a dynamic inflammatory process, not just ageing, it has been suggested that inflammatory biomarkers can predict outcomes in patients receiving TAVR [ 3 ] . It has been reported that persistently elevated levels of circulating plasma inflammatory proteins following TAVR are associated with increased cardiovascular and all-cause mortality [ 4 ] .…”