Association and relative importance of multiple obesity measures with bone mineral density: the National Health and Nutrition Examination Survey 2005–2006

Yang, Shuman; Shen, Xin

doi:10.1007/s11657-015-0219-2

Cited by 55 publications

(34 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The increase in fracture risk in T2DM is indeed observed in the setting of normal BMD. Possible explanations for such a "paradox of BMD" are the high frequency of obesity in these patients, and the well-known positive association between high BMI and high BMD (23). Additionally, the role of insulin resistance, and consequent high insulin levels, has been postulated, even though some studies failed to find a positive association with BMD independently of BMI (24).…”

Section: Advanced Glycation End-productsmentioning

confidence: 99%

The Interplay Between Bone and Glucose Metabolism

et al. 2020

View full text Add to dashboard Cite

The multiple endocrine functions of bone other than those related to mineral metabolism, such as regulation of insulin sensitivity, glucose homeostasis, and energy metabolism, have recently been discovered. In vitro and murine studies investigated the impact of several molecules derived from osteoblasts and osteocytes on glucose metabolism. In addition, the effect of glucose on bone cells suggested a mutual cross-talk between bone and glucose homeostasis. In humans, these mechanisms are the pivotal determinant of the skeletal fragility associated with both type 1 and type 2 diabetes. Metabolic abnormalities associated with diabetes, such as increase in adipose tissue, reduction of lean mass, effects of hyperglycemia per se, production of the advanced glycation end products, diabetes-associated chronic kidney disease, and perturbation of the calcium-PTH-vitamin D metabolism, are the main mechanisms involved. Finally, there have been multiple reports of antidiabetic drugs affecting the skeleton, with differences among basic and clinical research data, as well as of anti-osteoporosis medication influencing glucose metabolism. This review focuses on the aspects linking glucose and bone metabolism by offering insight into the most recent evidence in humans.

show abstract

Section: Advanced Glycation End-productsmentioning

confidence: 99%

The Interplay Between Bone and Glucose Metabolism

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although obesity was thought to be protective against all fractures, it substantially increased the risk of fractures in the ankle or lower leg Compston et al [2014] 52,939 women Inverse linear associations between BMI or weight and hip, spine, and wrist fracture Ho-Pham et al [2014] Meta-analysis: 44 studies, 20,226 individuals (4966 men and 15,260 women), 18-92 years old Lean mass exerts a greater effect on BMD than fat mass in men and women Søgaard et al [2015] 19,918 postmenopausal women; 23,061 men Abdominal obesity (CV) was associated with an increased risk of hip fracture Copês et al [2015] 1057 women Prevalence of fractures in obese and nonobese women was similar (17.3% versus 16.0%); 41.4% of all fractures occurred in obese women Yang and Shen [2015] 5287 individuals, 8-69 years old All obesity measures were positively associated with femoral neck BMD, but not with lumbar spine BMD. Greater BMI and hip circumference were the most important obesity measure in relation to BMD BMI, body mass index; CI, confidence interval; CV, cardiovascular; HBMD, high bone mineral density; LBMD, low bone mineral density; NS, nonsignificant; RR, relative risk; aFM, abdominal fat mass.…”

Section: Studymentioning

confidence: 99%

The obesity of bone

Greco

Lenzi

Migliaccio

2015

Therapeutic Advances in Endocrinology

134

View full text Add to dashboard Cite

During the last decades, obesity and osteoporosis have become important global health problems, and the belief that obesity is protective against osteoporosis has recently come into question. In fact, some recent epidemiologic and clinical studies have shown that a high level of fat mass might be a risk factor for osteoporosis and fragility fractures. Several potential mechanisms have been proposed to explain the complex relationship between adipose tissue and bone. Indeed, adipose tissue secretes various molecules, named adipokines, which are thought to have effects on metabolic, skeletal and cardiovascular systems. Moreover, fat tissue is one of the major sources of aromatase, an enzyme that synthesizes estrogens from androgen precursors, hormones that play a pivotal role in the maintenance of skeletal homeostasis, protecting against osteoporosis. Moreover, bone cells express several specific hormone receptors and recent observations have shown that bonederived factors, such as osteocalcin and osteopontin, affect body weight control and glucose homeostasis. Thus, the skeleton is considered an endocrine target organ and an endocrine organ itself, likely influencing other organs as well. Finally, adipocytes and osteoblasts originate from a common progenitor, a pluripotential mesenchymal stem cell, which has an equal propensity for differentiation into adipocytes or osteoblasts (or other lines) under the influence of several cell-derived transcription factors. This review will highlight recent insights into the relationship between fat and bone, evaluating both potential positive and negative influences between adipose and bone tissue. It will also focus on the hypothesis that osteoporosis might be considered the obesity of bone.

show abstract

“…In this study, diabetic and non-diabetic groups were matched according to age, sex and body mass index (BMI). Type 2 diabetes is routinely associated with overweight [30,31] and higher BMI is positively associated with BMD [32]. Nevertheless, overweight may be less protective against fractures than previously estimated [33,34] and recently it has been demonstrated that higher BMI did not modify BMD loss [2].…”

Section: Discussionmentioning

confidence: 98%

Bone mineral density and mandibular osteoporotic alterations in type 2 diabetes

Munhoz

Choi

Abdala

et al. 2018

BDS

View full text Add to dashboard Cite

Objective: To assess the influence of type 2 diabetes on bone mineral density in a group of type 2 diabetic patients, in comparison with non-diabetic patients. Additionally, to evaluate the correlation between mandibular cortical index and bone mineral density. Material and Methods: 48 patients (24 diabetics and 24 non-diabetics) referred for femur and spine densitometry and panoramic radiograph examination were included in this study. Patients were diagnosed based on densitometric results of the total femur and total spine. All panoramic radiomorphometric measurements were performed by 3 observers. Differences in T and Z-scores between both groups were evaluated with Mann-Whitney test and non-parametric correlations between mandibular cortical index and T/Z-scores were carried out with Spearman’s test. Results: Median T and Z-scores for total femur and total spine presented no statistical significant difference between diabetic and non-diabetic patients. In addition, only diabetics total femur and non-diabetics total spine T-scores were significantly correlated with mandibular cortical index. Conclusion: The present results suggest that type 2 diabetic patients have similar Z and T-scores in femur and spine when compared to non-diabetic patients. Mandibular cortical index, assessed on panoramic radiographs is inversely correlated with femur densitometry results in diabetics and spine bone mineral density in non-diabetic patients. KeywordsBone Mineral Density; Dual X-Ray Absorptiometry; Panoramic radiography; Osteoporosis; Type 2 Diabetes.

show abstract

Association and relative importance of multiple obesity measures with bone mineral density: the National Health and Nutrition Examination Survey 2005–2006

Abstract: All obesity measures were positively associated with femoral neck BMD, but not with lumbar spine BMD. Hip circumference was the most important obesity measure in relation to BMD.

Cited by 55 publications

References 38 publications

The Interplay Between Bone and Glucose Metabolism

The Interplay Between Bone and Glucose Metabolism

The obesity of bone

Bone mineral density and mandibular osteoporotic alterations in type 2 diabetes

Contact Info

Product

Resources

About