Association anévrysme de l'artère pulmonaire, thromboses intracardiaques et anticorps antiphospholipides au cours de la maladie de Behçet. À propos d'un cas

Harmouche, H.; Mezalek, Z. Tazi; Adnaoui, M.; Aouni, M.; Mohattane, A.; Maaouni, A.; Berbich, A

doi:10.1016/s0248-8663(99)80009-5

Cited by 17 publications

(4 citation statements)

References 17 publications

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“…4 Intracardiac thrombus formation is very uncommon. We conducted a cumulative literature search in which we were able to find only 24 cases previously published in 21 reports 3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] in which Behç et's disease was associated with intracardiac thrombus. We reviewed the clinical and pathologic correlates of cardiac thrombus formation in the context of Behç et's disease.…”

mentioning

confidence: 99%

Intracardiac Thrombus in Behçet's Disease

Moğulkoç

Burgess

Bishop

2000

Chest

190

155

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confidence: 99%

Intracardiac Thrombus in Behçet's Disease

Moğulkoç

Burgess

Bishop

2000

Chest

190

155

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“…It is believed that the pathogenesis of the thrombotic formation in patients with BD is due to endothelial cell ischemia or disruption that leads to enhancement of platelet aggregation; other possible pathogenic mechanisms, which affect approximately 18% of cases, is due to the presence of anti-phospholipid antibodies [ 13 – 15 ].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of SA Node at Supine Position in Right Atrial Thrombus Complicating Behçet’s Disease – From Cardiac Surgical Point of View

et al. 2016

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Patient: Female, 27Final Diagnosis: Right atrial thrombus compressing the sinoatrial nodeSymptoms: Dyspnea • cough and hemoptysis with supine bradycardia reaching 36/min and dizzinessMedication: —Clinical Procedure: Cardiac surgical intervention removing the mechanical cause if conservative management failed can be done safelySpecialty: SurgeryObjective:Rare diseaseBackground:Behçet’s disease (BD) is a chronic multi-systemic disease of unknown cause. Intra-cardiac thrombus (ICT) complicating BD is extremely rare. In general, cardiac manifestations in BD are associated with poor prognosis. Chest computed tomography (CT) scan and echocardiogram are excellent modalities for diagnosis and patient assessment. Cardiac surgical intervention can be done safely using an on-pump technique when medical management has failed.Case Report:We report on a case of a 27-year-old Jordanian woman diagnosed with BD who presented with dyspnea, cough, and hemoptysis, with supine bradycardia reaching 36 beats/minute and dizziness which disappear on sitting or standing position, and with heart rate reaching 76 beats/minute. Right atrial thrombus was identified using transthoracic echocardiogram and chest CT scan. After medical management failed, cardiac surgical intervention became an option and targeted extraction of the right atrial thrombus compressing the sinoatrial node (SA node).Conclusions:In BD, right atrial thrombus compressing the SA node is rare. If conservative management has failed, cardiac surgical intervention removing the mechanical cause can be done safely, either using on-pump with cross clamp or on-pump with beating heart technique.

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“…Aksu et al [102] revealed that mean plasma homocysteine levels in BD patients were significantly higher than in healthy controls. Another possible pathogenic mechanism of thrombosis in BD is attributed to the presence of anti-phospholipid antibodies, which have been reported in 18 % of cases [22].…”

Section: Discussionmentioning

confidence: 99%

Intracardiac thrombus in Behçet’s disease: four new cases and a comprehensive literature review

Aksu

Tüfekçioğlu

2014

Rheumatol Int

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Behçet's disease (BD) is a multisystem inflammatory disorder. Intracardiac thrombus formation (ICTF) is an uncommon but important complication of BD. To highlight recent insights into this disease, we aimed to review ICTF and other systemic involvements associated with ICTF in BD. We conducted a comprehensive review of the relevant literature in MEDLINE and EMBASE from 1966 to 2014 to analyze cumulated data about ICTF in BD. We aimed to evaluate 93 cases of BD with ICT (group 1), four of which have been recently identified and have not been discussed in the relevant literature yet, and to compare the frequency of pulmonary, venous and arterial involvements in group 1 and general Behçet population (group 2). The right heart was the most common site of ICTF in group 1. Pulmonary involvement, venous involvement (especially venous thrombosis) and arterial involvement were more frequent in group 1 than in group 2 (56 vs. 0.7 %, 42 vs. 10 % and 38 vs. 0.8 %, respectively, p < 0.0001). The diagnosis of BD should be considered if a patient presents with a mass in the right-sided cardiac chambers, even in the absence of the characteristic clinical manifestations of the illness. This approach is particularly applicable if the patient is a young man from the Mediterranean basin or the Middle East. All Behçet patients with ICTF must be investigated with thoracic computed tomography for pulmonary and arterial involvements and lower extremity venous Doppler ultrasonography for venous thrombosis, regardless of whether they are symptomatic for these systems.

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Association anévrysme de l'artère pulmonaire, thromboses intracardiaques et anticorps antiphospholipides au cours de la maladie de Behçet. À propos d'un cas

Cited by 17 publications

References 17 publications

Intracardiac Thrombus in Behçet's Disease

Intracardiac Thrombus in Behçet's Disease

Inhibition of SA Node at Supine Position in Right Atrial Thrombus Complicating Behçet’s Disease – From Cardiac Surgical Point of View

Intracardiac thrombus in Behçet’s disease: four new cases and a comprehensive literature review

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