Association between 11 genetic polymorphisms in folate-metabolising genes and head and neck cancer risk

Galbiatti, Ana Lívia Silva; Silva, Lidia Maria Rebolho Batista da; Ruiz-Cintra, Mariângela Torreglosa; Raposo, Luis Sérgio; Maníglia, José Victor; Pavarino, Érika Cristina; Goloni-Bertollo, Eny Maria

doi:10.1016/j.ejca.2011.09.025

Cited by 28 publications

(28 citation statements)

References 34 publications

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“…Lopez-Cortes et al found that the MTHFR C677T polymorphism has significant effects on susceptibility to prostate cancer in an Ecuadorian population [10]. Galbiatti et al reported that MTHFR and MTR polymorphisms are associated with risk of head and neck cancer [27]. In our study, MTHFR C677T and MTR A2756G polymorphisms played an important role in breast cancer risk, and had interactions with folate, vitamin B 6 , and vitamin B 12 intakes.…”

Section: Discussionmentioning

confidence: 63%

“…The MTHFR C677T, MTHFR A1298C, and MTR A2756G single nucleotide polymorphisms have been found to alter levels of folate and homocysteine, which changes the functionality of expressed proteins [25]. The MTHFR and MTR genes have been widely studied, and the MTHFR C677T, MTHFR A1298C, and MTR A2756G polymorphisms are associated with risk of several cancers [10,[26][27][28][29][30]. Lopez-Cortes et al found that the MTHFR C677T polymorphism has significant effects on susceptibility to prostate cancer in an Ecuadorian population [10].…”

Section: Discussionmentioning

confidence: 99%

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Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B12 intakes

Qiao

De-chuang

et al. 2014

Tumor Biol.

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We assessed the association between dietary intake of folate and the MTHFR genotype with breast cancer in a Chinese population, with additional analysis of the interactions of gene polymorphisms and dietary intake of folate, vitamin B6, and vitamin B12. A case-control study was performed, and 535 patients with newly diagnosed breast cancer and 673 controls were enrolled into this study. The MTHFR 667TT genotype (odds ratio (OR) = 1.82, 95 % confidence interval (CI) = 1.24-2.97) and T allele (OR 0= 1.48, 95 % CI = 1.15-1.78) were correlated with a moderately significant increased risk of breast cancer when compared with the CC genotype. Individuals carrying the MTR 2756GG genotype (OR = 1.66, 95 % CI = 1.16-2.56) and G allele (OR = 1.42, 95 % CI = 1.26-1.81) had a higher risk of breast cancer when compared with subjects with the AA genotype. The MTHFR 667 T allele and MTR 2756 G allele were associated with a higher risk of breast cancer in individuals with low folate intake, vitamin B6, and vitamin B12, but the association disappeared among subjects with moderate and high intake of folate, vitamin B6, and vitamin B12. This case-control study found that the MTHFR C677T and MTR A2756G polymorphisms are associated with risk of breast cancer, and folate, vitamin B6, and vitamin B12 intakes influence these associations.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B12 intakes

Qiao

De-chuang

et al. 2014

Tumor Biol.

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“…RFC1 80G allele was associated with an increased risk of head and neck carcinoma [43, 44], whereas an increased risk of gastric and esophageal cancer was found in association with the RFC180AA genotype [45]. The RFC1 80AA genotype was also associated with increased risk for acute lymphoid leukaemia with worse outcome [46], higher chance of relapse and poorer survival [47, 48] as compared to GA and GG genotypes.…”

Section: Discussionmentioning

confidence: 99%

The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers

et al. 2016

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Polymorphisms within one-carbon metabolism genes have been largely studied in relation to cancer risk for the function of this pathway in nucleotide synthesis and DNA methylation. Aims of this study were to explore the possible link among several common functional gene polymorphisms within one-carbon metabolism and survival rate in primary liver cancers, i.e., hepatocellular carcinoma and cholangiocarcinoma, and to assess the additional effect of global DNA methylation on survival rate and mortality risk. Forty-seven primary liver cancer patients were genotyped for ten polymorphisms: DHFR 19bp ins/del, TS 2rpt-3rpt, MTHFD1 1958G>A, MTHFR 677C>T, MTR 2756A>G, MTRR 66A>G, RFC1 80G>A, SHMT1 1420C>T, BHMT 716 A>G, TC II 776C>G. Methylation was determined in peripheral blood mononuclear cells (PBMCs) DNA as methylcytosine (mCyt) content using LC/MS/MS. Among the polymorphisms analysed, the RFC1 80G>A (rs1051266) influenced the survival rate in primary liver cancers. The RFC1 80AA was associated to a significantly reduced survival rate (22.2%) as compared to both GG and GA genotypes (61.5% and 76% respectively, p = 0.005). When the cancer patients were stratified according to the mCyt median value as high (>5.34%) or low (≤5.34%), the concomitant presence of AA genotype and low mCyt level led to a significantly worse survival rate as compared to the G allele carriership (p<0.0001) with a higher Hazard Ratio (HR = 6.62, p = 0.001). The subjects carrying the AA genotype in association with high mCyt did not show a significant difference in survival rate as compared with the G allele carriers (p = 0.919). The RFC1 80G>A polymorphism influenced the survival rate, and the presence of RFC1 80AA genotype with low global methylation in PBMCs DNA was associated with poorer prognosis and higher mortality risk, therefore highlighting novel molecular signatures potentially helpful to define prognostic markers for primary liver cancers.

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“…The influences of MTHFR genotypes for SNPs rs1801133 and rs18091131 on other health outcomes, including lung cancer (53), head and neck squamous cell carcinoma (54), and type 2 DM are well established (24).…”

Section: Mthfrmentioning

confidence: 99%

Gender and Single Nucleotide Polymorphisms inMTHFR,BHMT,SPTLC1,CRBP2,CETP, andSCARB1Are Significant Predictors of Plasma Homocysteine Normalized by RBC Folate in Healthy Adult

Clifford

Chen

McWade

et al. 2012

The Journal of Nutrition

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Using linear regression models, we studied the main and 2-way interaction effects of the predictor variables gender, age, BMI, and 64 folate/vitamin B-12/homocysteine (Hcy)/lipid/cholesterol-related single nucleotide polymorphisms (SNP) on log-transformed plasma Hcy normalized by RBC folate measurements (nHcy) in 373 healthy Caucasian adults (50% women). Variable selection was conducted by stepwise Akaike information criterion or least angle regression and both methods led to the same final model. Significant predictors (where P values were adjusted for false discovery rate) included type of blood sample [whole blood (WB) vs. plasma-depleted WB; P < 0.001] used for folate analysis, gender (P < 0.001), and SNP in genes SPTLC1 (rs11790991; P = 0.040), CRBP2 (rs2118981; P < 0.001), BHMT (rs3733890; P = 0.019), and CETP (rs5882; P = 0.017). Significant 2-way interaction effects included gender × MTHFR (rs1801131; P = 0.012), gender × CRBP2 (rs2118981; P = 0.011), and gender × SCARB1 (rs83882; P = 0.003). The relation of nHcy concentrations with the significant SNP (SPTLC1, BHMT, CETP, CRBP2, MTHFR, and SCARB1) is of interest, especially because we surveyed the main and interaction effects in healthy adults, but it is an important area for future study. As discussed, understanding Hcy and genetic regulation is important, because Hcy may be related to inflammation, obesity, cardiovascular disease, and diabetes mellitus. We conclude that gender and SNP significantly affect nHcy.

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Association between 11 genetic polymorphisms in folate-metabolising genes and head and neck cancer risk

Cited by 28 publications

References 34 publications

Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B12 intakes

Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B12 intakes

The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers

Gender and Single Nucleotide Polymorphisms inMTHFR,BHMT,SPTLC1,CRBP2,CETP, andSCARB1Are Significant Predictors of Plasma Homocysteine Normalized by RBC Folate in Healthy Adult

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