Association Between - 675 ID, 4G/5G PAI-1 Gene Polymorphism and Pregnancy Loss: A Systematic Review

Adler, Grażyna; Mahmutbegović, Emir; Valjevac, Amina; Adler, Mateusz A.; Mahmutbegović, Nevena; Safranow, Krzysztof; Czerska, Ewa; Pawińska-Matecka, Anna; Ciechanowicz, Iwona; Marjanović, Damir

doi:10.5455/aim.2018.26.156-159

Cited by 13 publications

(13 citation statements)

References 23 publications

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“…There were no listed allele frequencies of PAI in the genomic databases and we were unable to calculate the genotype frequecies.That is why we cannot conclude if PAI is a risk factor for vascular disorders or RPL. In spite of that, in a study by Adler, G., et al there was a statistically significant association between carrying 4G allele and RPL in Bulgarian women (p = 0.018) [32]. However, there is no guideline, suggesting to include PAI polymorphisms in the thrombophilia panel and more studies are needed to prove this finding in the Bulgarian population.…”

Section: Discussionmentioning

confidence: 93%

Comparison between thrombophilic gene polymorphisms among high risk patients

Levkova

Hachmeriyan

Stoyanova

et al. 2020

Romanian Journal of Internal Medicine

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Introduction. The purpose of this study was to compare the role of the thrombophilic variants among two groups of high risk patients with vascular disorders and recurrent pregnancy loss.Methods. 200 patients, including 76 with thrombotic accidents and 124 with two or more idiopathic recurrent miscarriage during the first trimester, were tested for the presence of Factor V (F V) Leiden G1691A, Factor II (F II) G20210A, plasminogen activator inhibitor (PAI) 4G/5G, and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms using Real time polymerase chain reaction (RT – PCR) in the Laboratory of Medical Genetics, Varna, Bulgaria between June 2016 and May 2019. Frequencies of thrombophilic gene polymorphisms were compared among the two populations and to the expected genotype frequencies.Results. Individuals with a history of vascular disorders had a significantly higher frequency of F V Leiden variant compared to women with recurrent miscariage. There was no statistical difference between the analyzed patients for the other three thrombophilic polymorphisms. The allelic frequencies and the expected genotype frequencies of the F V, F II and MTHFR polymorphisms were calculated according to Hardy-Weinberg equilibrium. The percentages of the homozygotes for F V and F II were higher than expected in the two groups of patients. For the MTHFR there was no difference.Conclusion. F V Leiden remains the strongest risk factor for vascular disorders and recurrent pregnancy loss. Screening for this variant should be recommended to patients with thrombotic accidents and women with repeated miscarriage. The role of F II, PAI and MTHFR remains controversial.

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Section: Discussionmentioning

confidence: 93%

Comparison between thrombophilic gene polymorphisms among high risk patients

Levkova

Hachmeriyan

Stoyanova

et al. 2020

Romanian Journal of Internal Medicine

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“…However, later studies in different ethnicities yielded controversial results ( 18 , 34 , 42 , 43 ) . In 2018, Adler et al ( 44 ) evaluated the associations of the -675 I/D and 4G/5G polymorphisms and PAI-1 with susceptibility to pregnancy loss in European and worldwide populations. Their pooled data revealed that there was no significant relationship between the 4G/5G polymorphism and pregnancy loss both in Europe or elsewhere in the world.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of the association of the ACE I/D and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Iranian women: Are the investigations adequate?

Dastgheib¹,

Karimi-Zarchi²,

Bahrami³

et al. 2021

tjod

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The associations of ACE I/D and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss (RPL) in Iranian women have yielded controversial results. Thus, we conducted a meta-analysis to obtain more certain results. A comprehensive literature search was performed in the PubMed, Web of Sciences, Scopus, MedRxiv, SID, and CNKI databases up to January 1st, 2021, using the appropriate terms. All case-control studies were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of associations. A total of 14 studies including eight studies with 783 patients and 761 healthy subjects on ACE I/D and six studies with 1.155 patients and 699 healthy subjects on PAI-1 4G/5G were included. Combined data revealed that ACE I/D polymorphism was significantly associated with RPL risk in Iranian women under three models i.e., allele [OR=0.744, 95% CI: (0.640-0.864); p≤0.001], dominant [OR=0.774, 95% CI: (0.601-0.996); p=0.047], and recessive [OR=0.767, 95% CI: (0.611-0.963); p=0.022]. Moreover, the pooled data showed a significant association between the PAI-1 4G/5G polymorphism and RPL risk under all five models i.e., allele [OR=2.352, 95% CI: (1.623-3.408); p≤0.001], heterozygote [OR=8.364, 95% CI: (4.744-14.756); p≤0.001), homozygote [OR=2.192, 95% CI: (1.093-4.394); p=0.027), dominant [OR=2.354, 95% CI: (1.309-4.235); p=0.004], and recessive [OR=5.208, 95% CI: (3.005-9.025); p≤0.001]. Stratification analysis revealed that these polymorphisms were associated with RPL risk by the number of miscarriages. Our pooled data indicated that ACE I/D and PAI-1 4G/5G polymorphisms were significantly associated with an increased risk of RPL in Iranian women. These significant findings showed that the investigation might be adequate for ACE I/D and PAI-1 4G/5G polymorphisms in the Iranian population.

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“…Yet, the most common cause of pregnancy loss is unexplained. 12 The coagulation pathway has a major role in the placental development and the balance between the clotting and fibrinolytic system is mandatory for a successful implantation. 13 PAI-1 is considered an important regulator in the fibrinolytic system.…”

Section: Discussionmentioning

confidence: 99%

Detection of plasminogen activator inhibitor-1 (-675 4G/5G) gene polymorphism in women with recurrent abortion

Shaala¹,

Deghady²,

Elwafa³

et al. 2019

HTIJ

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Background: recurrent abortion is considered one of the most common complications that occur during pregnancy and counts for 15% of pregnancies that are recognized clinically. Many causes can be attributed to the recurrent pregnancy loss e.g. chromosomal anomalies, thrombophilic disorders, uterine anomalies, endocrine abnormalities and fetal anomalies. Thrombophilia can be either hereditary or acquired. Multiple genes had been implicated in the pathogenesis of the thrombophilia. Previous studies have indicated that genetic polymorphism of the plasminogen activator inhibitor-1 gene (PAI-1) may be associated with recurrent abortion. Aim:The aim of the present study was to investigate whether plasminogen activator inhibitor-1 (-675 4G/5G) gene polymorphism is associated with the occurrence of recurrent pregnancy loss or not.Methods: DNA samples were collected from sixty six female patients with recurrent abortion (33 primary abortion, 33 secondary abortion) and thirty four healthy controls with normal pregnancy for detection of plasminogen activator inhibitor-1 (-675 4G/5G) gene polymorphism by restriction fragment length polymorphism PCR.Results: there was a significant association between PAI-1(-675 4G/5G) polymorphism and the occurrence of recurrent pregnancy loss. Conclusion:Our results assumed that PAI-1 (-675 4G/5G) polymorphism is associated with recurrent pregnancy loss.

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Association Between - 675 ID, 4G/5G PAI-1 Gene Polymorphism and Pregnancy Loss: A Systematic Review

Cited by 13 publications

References 23 publications

Comparison between thrombophilic gene polymorphisms among high risk patients

Comparison between thrombophilic gene polymorphisms among high risk patients

A meta-analysis of the association of the ACE I/D and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Iranian women: Are the investigations adequate?

Detection of plasminogen activator inhibitor-1 (-675 4G/5G) gene polymorphism in women with recurrent abortion

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