Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults

Abstract

OBJECTIVES Diabetes is a well-known risk factor for atherosclerosis, but the association between a family history of diabetes and atherosclerosis remains unknown. In this study, we assessed the association between a family history of diabetes and increased carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in a middle-aged Korean population. METHODS This cross-sectional study included 3,974 community-dwelling adults (1,404 male and 2,570 female) aged 30-64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort. The presence of a family history of diabetes was assessed through face-to-face interviews using a standardized questionnaire. Carotid IMT was assessed using B-mode ultrasonography, and increased IMT was defined as a value in the top quartile of the IMT values of all participants. Multivariate logistic regression was used to evaluate independent associations between a family history of diabetes and increased IMT. RESULTS A family history of diabetes was significantly associated with increased carotid IMT (odds ratio, 1.23; 95% confidence interval, 1.03 to 1.48) after adjusting for sex; age; body mass index; systolic blood pressure; total cholesterol, triglyceride, and hemoglobin A1c levels; smoking; alcohol consumption; exercise; use of antidiabetic, antihypertensive, and antilipidemic drugs; and a family history of hypertension. The positive association remained significant after excluding participants with diabetes (odds ratio, 1.21; 95% confidence interval, 1.00 to 1.47). CONCLUSIONS A family history of diabetes was positively associated with increased carotid IMT, even in participants without diabetes. Therefore, information on a family history of diabetes may help identify individuals at high risk of atherosclerotic cardiovascular disease.

Citropten Inhibits Vascular Smooth Muscle Cell Proliferation and Migration via the TRPV1 Receptor

“…Diabetes is a primary risk factor for atherosclerosis, stroke, coronary heart disease, and dyslipidemia. Increased risk and accelerated development of atherosclerosis have been reported in patients with diabetes and high blood pressure . In this study, we demonstrated a novel role of citropten in regulating VSMCs proliferation and migration in response to HG.…”

“…Increased risk and accelerated development of atherosclerosis have been reported in patients with diabetes and high blood pressure. 30 In this study, we demonstrated a novel role of citropten in regulating VSMCs proliferation and migration in response to HG. The mRNA and protein expression of proliferation markers (cyclin D1, cyclin E1, and PCNA) and migration targets (MMP2 and MMP9) was inhibited by citropten in HG-challenged cultured RVSMCs.…”

Clinical traits and systemic risks of familial diabetes mellitus according to age of onset and quantity: an analysis of data from the community-based KoGES cohort study

“…This indicates another significant role of genetic traits in familial DM regarding the development of cardiometabolic diseases among the participants. Because various risk factors for metabolic syndrome commonly coexist, family members with DM may have other risk factors [ 17 ]. This aggregated tendency may affect participants equally.…”

“…Because various risk factors for metabolic syndrome commonly coexist, family members with DM may have other risk factors. 17 This aggregated tendency may affect participants equally. As a result of the possibility of aggregated risk factors for metabolic syndrome, the association between cardiometabolic diseases may be significant.…”