Association between a promoter polymorphism (rs2192752, –1028A/C) of interleukin 1 receptor, type I (IL1R1) and location of papillary thyroid carcinoma in a Korean population

Park, S. W.; Kim, M. K.; Kwon, Kee Hwan; Kim, J.

doi:10.1111/j.1744-313x.2012.01125.x

Cited by 9 publications

(12 citation statements)

References 28 publications

(48 reference statements)

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“…Although the significance of rs3917225 is decreased after adjustment for age and gender, the results of this variant could not be fully ignored as a result of its potential effect on thyroid cancer susceptibility in the Chinese Han population. Furthermore, research on a Korean cohort suggested that there was no existing relationship between rs3917225 and the location of PTC, whereas another promoter SNP, rs2192752, harbored a potential role in PTC location and development . Our results corroborate that the substitution occurring on rs3917225 (A to G) might alter the risk of thyroid cancer to a certain degree.…”

Section: Discussionsupporting

confidence: 79%

“…In this process, two identified receptors, IL1R1 and IL1R2, act as signal receivers that function distinctly and lead to different reaction results, whereas less is known with respect to their genetic variations in relation to thyroid cancer. A previous study focused on the promoter SNPs of IL1R1 and concluded that SNP rs2192752 might be associated with the risk of PTC . Considering the involvement of IL activities in various diseases, we have carried out a series of investigations of different genes and cancers and, in the present study, we evaluated the correlations between the IL1R1 and IL1R2 polymorphisms and thyroid tumorigenesis.…”

Section: Discussionmentioning

confidence: 97%

“…Their distinct roles in thyroid cancer development may actually be worthy of more attention. A previous study investigated the association of rs2192752 within IL1R1 and papillary thyroid carcinoma (PTC) risk in a population from Korea, highlighting the significance of rs2192752 in the development of PTC . However, the risk associations of IL1R1 and IL1R2 polymorphisms with thyroid cancer are seldom reported in the Chinese Han population.…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms in IL1R1 and IL1R2 are associated with susceptibility to thyroid cancer in the Chinese Han population

Xiong

Sun

et al. 2019

The Journal of Gene Medicine

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Background Thyroid carcinoma accounts for a large part of endocrine neoplasia and the relationship between inflammation and thyroid cancer has been validated previously. Two known receptors of interleukin (IL)‐1, IL‐1 receptor 1 (IL1R1) and IL‐1 receptor 2 (IL1R2), are implicated in numerous inflammatory responses. The present study aimed to assess the genetic polymorphisms of IL1R1 and IL1R2 with respect to thyroid cancer in the Chinese Han population. Methods Eleven single nucleotide polymorphisms of IL1R1 and IL1R2 were identified among 241 thyroid cancer patients and 463 controls using the Agena MassARRY method (http://www.internationalgenome.org/). Genetic models and haplotype analysis were carried out to evaluate the significant links between the variants and the risk of thyroid cancer. Results Logistic regression analyses revealed significant associations of rs3917225, rs2072472 and rs11674595 with susceptibility to thyroid cancer. Haplotype analysis presented two blocks of IL1R2, whereas no statistical significance existed. Conclusions These findings suggested that rs3917225, rs2072472 and rs11674595 are risk factors associated with the development of thyroid carcinoma in Chinese Han people.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic polymorphisms in IL1R1 and IL1R2 are associated with susceptibility to thyroid cancer in the Chinese Han population

Xiong

Sun

et al. 2019

The Journal of Gene Medicine

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“…Nakki et al 32 showed that the A allele is associated with severe hand osteoarthritis. Park et al 33 polymorphism did not associated with papillary thyroid carcinoma. One of the most investigated polymorphisms in the IL1R1 gene is the SNP rs2234650:C.T (also known as 1970 C/ T PstI).…”

Section: Discussionmentioning

confidence: 99%

Relationship between interleukin-1 type 1 and 2 receptor gene polymorphisms and the expression level of membrane-bound receptors

Vasilev¹,

Silkov²,

Сенников³

2014

Cell Mol Immunol

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The biological activity of the multifunctional cytokine interleukin-1 (IL-1) is mediated by its receptors. The aim of this study was to determine if an association exists between single nucleotide polymorphisms (SNPs) in the IL-1 type 1 and 2 receptor genes (IL1R1 and IL1R2) and the expression level of membrane-bound IL1Rs on subpopulations of mononuclear cells or serum levels of soluble IL-1 receptors. It was observed that healthy individuals with the genotype TT in SNP rs2234650:C.T had a lower percentage of intact CD14 1 monocytes expressing IL1R1 on their surface. The SNP rs4141134:T.C in IL1R2 has also been associated with the percentage of intact CD3 1 T cells expressing IL1R2. Keywords: interleukin-1; membrane-bound receptor; SNPs; soluble receptor INTRODUCTION Interleukin-1 (IL-1) is a cytokine involved in a wide range of physiological processes, including having a central role in the regulation of acute and chronic inflammation. 1,2 The biological effects of IL-1 (IL-1a and IL-1b) are achieved by the binding of the cytokine to the membrane-bound IL-1 type 1 receptor (IL1R1). 3,4 IL1R1 is a glycoprotein with a molecular mass of 80 kDa that is predominantly expressed on endothelial cells, smooth muscle cells, epithelial cells, hepatocytes, fibroblasts, keratinocytes, epidermal dendritic cells and T lymphocytes. 5 IL-1 binding to the extracellular domain of IL1R1 promotes the recruitment of the IL-1 receptor accessory protein, which leads to signal transduction mediated by the cytoplasmic domains of IL1R1 and IL1R2 receptors. 6 The IL-1 type 2 receptor (IL1R2) is unable to initiate signaling and only acts as a 'decoy' receptor. 3,7 IL1R2 is a glycoprotein with a molecular mass of 60 kDa that is expressed on monocytes, neutrophils, T and B lymphocytes. 8,9 Studies have also provided evidence for the existence of soluble receptors for

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“…Alterations in serum concentrations of IL1b have been suggested to differentiate PTCs from atrophic thyroiditis (Kammoun-Krichen et al 2012). The inheritance of the polymorphism rs2192752 in IL1 receptor (IL1R1) increases the risk of PTC, indicating an association of this IL with DTC (Park et al 2012).…”

Section: Transforming Growth Factor Bmentioning

confidence: 99%

The role of the inflammatory microenvironment in thyroid carcinogenesis

Cunha¹,

Marcello²,

Ward³

2013

Endocrine-Related Cancer

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Immune responses against thyroid carcinomas have long been demonstrated and associations between inflammatory microenvironment and thyroid carcinomas repeatedly reported. This scenario has prompted scientists throughout the world to unveil how the inflammatory microenvironment is established in thyroid tumors and what is its influence on the outcome of patients with thyroid carcinoma. Many studies have reported the role of evasion from the immune system in tumor progression and reinforced the weakness of the innate immune response toward thyroid cancer spread in advanced stages. Translational studies have provided evidence that an increased density of tumor-associated macrophages in poorly differentiated thyroid carcinoma (DTC) is associated with an aggressive phenotype at diagnosis and decreased cancer-related survival, whereas well-DTC microenvironment enriched with macrophages is correlated with improved disease-free survival. It is possible that these different results are related to different microenvironments. Several studies have provided evidence that patients whose tumors are not infiltrated by lymphocytes present a high recurrence rate, suggesting that the presence of lymphocytes in the tumor microenvironment may favor the prognosis of patients with thyroid carcinoma. However, the effect of lymphocytes and other immune cells on patient outcome seems to result from complex interactions between the tumor and immune system, and the molecular pattern of cytokines and chemokines helps to explain the involvement of the immune system in thyroid tumor progression. The inflammatory microenvironment may help to characterize aggressive tumors and to identify patients who would benefit from a more invasive approach, probably sparing the vast majority of patients with an indolent disease from unnecessary procedures.

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Association between a promoter polymorphism (rs2192752, –1028A/C) of interleukin 1 receptor, type I (IL1R1) and location of papillary thyroid carcinoma in a Korean population

Cited by 9 publications

References 28 publications

Genetic polymorphisms in IL1R1 and IL1R2 are associated with susceptibility to thyroid cancer in the Chinese Han population

Genetic polymorphisms in IL1R1 and IL1R2 are associated with susceptibility to thyroid cancer in the Chinese Han population

Relationship between interleukin-1 type 1 and 2 receptor gene polymorphisms and the expression level of membrane-bound receptors

The role of the inflammatory microenvironment in thyroid carcinogenesis

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