“…However, many studies have shown that the metabolic by-products from having diabetes, particularly when it is poorly controlled, damage the small unmyelinated peripheral nerve function prior to the large myelinated nerve fibre [5]. Sympathetic skin response (SSR), as an objective electrophysiological marker to evaluate the autonomic unmyelinated nerve fibre function, has been used in the diagnosis and prognosis assessment of many diseases, such as pediatric Guillain-Barré syndrome [6], amyotrophic lateral sclerosis [7], multiple sclerosis [8], and adult diabetes mellitus [9], etc. The SSR study of pediatric diabetes mellitus is rare, therefore, the purpose of our study is to explore SSR characteristics in children living with T1DM and analyze the value of early diagnosis and follow-up in T1DM complicated with DPN.…”