Association between ABCA1 Gene Polymorphisms and Plasma Lipid Concentration: A Systematic Review and Meta-Analysis

Shim, Sun-Young; Yoon, Ha-Young; Yee, Jeong; Han, Jimin; Gwak, Hye Sun

doi:10.3390/jpm11090883

Cited by 4 publications

(9 citation statements)

References 43 publications

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“…Previous studies suggested that the ABCA1 C69T polymorphism variant is the upstream variant of ABCA1 gene (ENST00000374736.8) in the non-coding region shown to be associated with a decreased incident rate of T2DM [ 26 ]. In addition, a recent meta-analysis of studies conducted on Asian people (mainly Chinese) reached the same conclusion [ 20 ]. However, ethnicity has been reported to play a role in the determination of genetic risk factors [ 27 , 28 ], and indeed, others have reported no effects in Bangladeshi [ 29 ], Malaysian [ 30 ], or Caucasian subjects [ 31 ].…”

Section: Introductionmentioning

confidence: 66%

“…However, in most cases, prediabetes remains undiagnosed and hence untreated, allowing further deterioration in metabolic regulation and worsening micro and macro-vascular complications [ 7 , 8 , 9 ]. Indeed, studies have shown an association between prediabetes and increased risk of complications of diabetes such as early nephropathy, small fiber neuropathy, early retinopathy and risk of macrovascular disease [ 17 , 18 , 19 , 20 , 21 ]. In contrast, an Iranian study reported an association between dyslipidemia and prediabetes [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…The ATP-binding cassette transporter A1 (ABCA1) is a cell membrane transport protein composed of 2261 amino acids [ 20 ]. The main function of ABCA1 is to promote the efflux of cellular cholesterol and phospholipids [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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ABCA1 C69T Gene Polymorphism Association with Dysglycemia in Saudi Prediabetic Adults

Ajabnoor

Bahijri²,

Alrashidi³

et al. 2022

Genes

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Studies suggest that ATP-binding cassette transporter A1 (ABCA1 C69T) polymorphism is associated with a decreased incidence of type 2 diabetes mellitus (T2DM) and that there is an association between ABCA1 C69T polymorphism and the risk of dyslipidemia in diabetic individuals. However, other studies contradict these suggestions. Therefore, we aimed to investigate the prevalence of ABCA1 C69T (rs1800977) gene polymorphism in a representative sample of the Saudi population not previously diagnosed with diabetes and its possible association with dyslipidemia and dysglycemia. A cross-sectional design was used to recruit nondiabetic adults of both genders from the Saudi population in Jeddah by employing a stratified, two-stage cluster sampling method. A total of 650 people (337 men and 313 women) were recruited. Demographic, dietary, and lifestyle variables, as well as medical history and family history of chronic diseases, were collected using a predesigned questionnaire. Fasting blood samples were taken for the determination of fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), and lipids profile, which were followed by a 1-h oral glucose tolerance test (OGTT). Real-time PCR technology was used to determine the ABCA1 C69T gene SNP (rs1800977). The T allele of ABCA1 C69T (rs1800977) was very frequent (TT in 44.9% and CT in 43.7%). There was a trend toward significance for a higher dysglycemia percentage in people with CT and TT genotypes (25.7%, and 23.3%, respectively) compared with CC genotypes (16.2%). In addition, FPG and 1-h plasma glucose were significantly higher in people with both TT and CT genotypes compared to CC genotypes. However, T allele was not associated with any dysregulation of lipid parameters.

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Section: Introductionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

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ABCA1 C69T Gene Polymorphism Association with Dysglycemia in Saudi Prediabetic Adults

Ajabnoor

Bahijri²,

Alrashidi³

et al. 2022

Genes

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“…No statistically significant differences were observed between the case and control groups, depicting that there is a possibility of an inherent disruption in HDL-c metabolism among the Indian population. A previous meta-analysis conducted by Shim et al (11), reported on the inconsistencies in lipid levels and ABCA1 variants. The association between the two SNPs and lipid profiles was assessed in the present study, and no substantial association (P>0.05) was found for these parameters and the genotype distribution (Table IV).…”

Section: Discussionmentioning

confidence: 99%

“…The association between the genetic polymorphism in the ABCA1 gene and the decrease in HDL-c levels has been demonstrated in recent years (10). A systematic review and meta-analysis on studies that determined the association between the ABCA1 gene polymorphism and T2DM, revealed inconsistent results (11). The divergence may be due to the influence of ethnicity, genetic susceptibility, and environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study

Balasundararaj

Gayathri

2022

World Acad Sci J

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Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder associated with alterations in the metabolism of carbohydrates, proteins and lipids. ATP binding cassette transporter 1 (ABCA1) encoding the ABCA1 protein plays a critical role in the reverse cholesterol transport of high-density lipoprotein-cholesterol (HDL-c) metabolism. ABCA1 gene single nucleotide polymorphisms (SNPs) have been found to be associated with abnormalities in the serum levels of HDL-c, thereby disrupting the cholesterol removing ability of cells. The aim of the present study was to determine the association between the R219K and C69T SNPs of ABCA1 gene variants and T2DM. For this purpose, a case control study was conducted among 50 patients with T2DM who were selected as cases, and 50 age-and sex-matched patients without comorbidities were selected as the controls. Venous blood samples were collected from all participants following overnight fasting. Plasma glucose, glycated hemoglobin (HbA1c) and lipid profile estimations were performed using an autoanalyzer with standard methods. ABCA1 gene polymorphisms were determined using the polymerase chain reaction-restriction fragment length polymorphism method. The body mass index for both the case and control groups was found to be above the revised cut-off value for obesity. HDL-c levels were below the optimum level in the case and control group. The distribution of genotype and dominant alleles of the C69T and R219K SNPs of the ABCA1 gene did not differ significantly between the case and control groups. The present study suggests the existence of a defective ABCA1 genotype in the studied population, predisposing these individuals to a decrease in serum HDL-c levels. This interferes with cholesterol sequestration from foam cells and creates an inflammatory state, which is aggravated by obesity. Thus, HDL-c becomes dysfunctional from inflammation-mediated structural modifications and paves the way for atherogenic dyslipidemia associated with T2DM.

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Expression analysis of ABCA1 in type 2 diabetic Pakistani patients with and without dyslipidemia and correlation with glycemic index and lipid profile

Zaidi,

Rashid,

Majeed

et al. 2023

Sci Rep

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Diabetes Mellitus type II, earlier considered as an endocrinological disorder is now more regarded as an inflammatory disorder along with lipid aberrations. It demands for regular monitoring, healthy dietary habits and lifestyle modification. This study was focused on gene expression of ATP binding cassette protein 1 (ABCA1) in diabetic dyslipidemia patients in comparison with control groups of only diabetics and healthy individuals. Blood samples and data were collected from recruited 390 patients who were further divided into three groups (130 each). Glycemic index and lipid profile was assessed. Delta Delta Ct method was used that revealed downregulation of the studied gene more in diabetic dyslipidemia patients as compared to only diabetics and healthy controls. The Ct values of ABCA1 were associated with glycemic index and lipid profile using Pearson’s correlation. A negative correlation with fasting blood sugar and a positive correlation with HbA1cwas observed in only diabetics group. While in diabetic dyslipidemia and normal healthy controls, a negative correlation was found with both. As far as the lipid profile is concerned a positive correlation was observed among only diabetics with whole lipid profile. In diabetics with dyslipidemia, a negative correlation with all parameters except the TAGs was observed. A positive correlation with all except HDL was observed in healthy controls. The Ct values and fold change were compared among diseased and healthy individuals by applying independent t test. The cycle threshold in only diabetics was p = 0.000018 and in diabetic dyslipdemia individuals was p = 0.00251 while fold change in only diabetics (p = 0.000230) and in diabetics with dyslipidemia (p = 0.001137) was observed to be as statistically significant.

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Association between ABCA1 Gene Polymorphisms and Plasma Lipid Concentration: A Systematic Review and Meta-Analysis

Cited by 4 publications

References 43 publications

ABCA1 C69T Gene Polymorphism Association with Dysglycemia in Saudi Prediabetic Adults

ABCA1 C69T Gene Polymorphism Association with Dysglycemia in Saudi Prediabetic Adults

Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study

Expression analysis of ABCA1 in type 2 diabetic Pakistani patients with and without dyslipidemia and correlation with glycemic index and lipid profile

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