Association between active Wegener's granulomatosis and anticytoplasmic antibodies

Tervaert, Jwc

doi:10.1001/archinte.149.11.2461

Cited by 262 publications

(228 citation statements)

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“…Although neither the presence of ANCA nor their titer seemed to be associated with RA disease activity, longitudinal studies are needed to determine whether an increase in titer precedes a relapse of the disease, as has been noted by some authors (7,43), but not by others (44), with respect to anti-PR3 antibodies in Wegener's granulomatosis patients. Further study is also needed to elucidate the significance of the association between ANCA and longstanding RA.…”

Section: Discussionmentioning

confidence: 95%

Antineutrophil cytoplasmic antibodies in rheumatoid arthritis. characterization and clinical correlations

Mulder¹,

Horst²,

Leeuwen³

et al. 1993

Arthritis & Rheumatism

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Objective. To study the prevalence, interrelationships, and target antigens of antineutrophil cytoplasmic antibodies (ANCA) in rheumatoid arthritis (RA) and to relate their presence to disease duration and to the occurrence of extraarticular manifestations, including vasculitis. Methods. Sera from 94 patients with RA (31 with recent‐onset disease, 35 with longstanding disease but without extraarticular manifestations, and 28 with extraarticular disease) were studied for the presence of ANCA by indirect immunofluorescence. All sera were tested by enzyme‐linked immunosorbent assay (ELISA) for the presence of antibodies to proteinase 3, myeloperoxidase (MPO), elastase, lactoferrin (LF), and cathepsin G (CG), and by Western blotting for antibodies to neutrophil proteins. Results. Seventy percent of the 94 sera showed staining of the nuclei of ethanol‐fixed neutrophils; 32% of the 94 were proven to have ANCA, as manifested by their cytoplasmic staining pattern on paraformaldehyde‐fixed neutrophils. In the ELISA, 19 sera reacted with LF, 1 with MPO, and 1 with CG. By Western blotting, 21 sera reacted with LF, and 15 reacted with previously unknown polypeptides (7 sera with a 67/66‐kd doublet and 8 with a 63/54‐kd doublet). Neither of these antibodies was associated with a particular subset of the disease, but the prevalence of the antibodies tended to increase among patients with longstanding disease. Conclusion. ANCA in RA patients are directed toward diverse cytoplasmic antigens of the neutrophil, in particular, LF and other, not yet fully characterized polypeptides. The antibodies are not a marker for a disease subset, but are probably a corollary of chronic inflammation.

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Section: Discussionmentioning

confidence: 95%

Antineutrophil cytoplasmic antibodies in rheumatoid arthritis. characterization and clinical correlations

Mulder¹,

Horst²,

Leeuwen³

et al. 1993

Arthritis & Rheumatism

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“…Indeed, in patients with clinically quiescent AAV, high ANCA titers can persist without reactivation of vasculitis (5,(32)(33)(34). It has been suggested that the characteristics of ANCA present in active disease may differ from those present in disease remission and in sera from patients without vasculitis, possibly in the mechanism of neutrophil activation (7,35).…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence that ANCA play a pathophysiologic role in the induction of these vasculitides. First, elevations in ANCA titers appear to correlate with risk of future disease flares, although they do not reliably predict the timing of such flares (4,5). Second, it has been demonstrated in vitro that ANCA induce neutrophil activation, i.e., degranulation and production of a respiratory burst (6).…”

Section: Introductionmentioning

confidence: 99%

Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long‐term followup study

Slot¹,

Links²,

Stegeman³

et al. 2005

Arthritis & Rheumatism

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“…Recently these autoantibodies have been implicated in the pathogenesis of the disease [8][9][10][11][12][13][14][15][16][17]. Two types of ANCA have been described, based on the characteristic immunofluorescence staining patterns on alcohol-fixed neutrophils incubated with sera from patients: antibodies exhibiting a cytoplasmic pattern (C-ANCA) and antibodies exhibiting a perinuclear staining pattern (P-ANCA) [5].…”

Section: Introductionmentioning

confidence: 99%

Up-regulation of the granulocyte adhesion molecule Mac-1 by autoantibodies in autoimmune vasculitis

Johnson¹,

Alexander²,

McMillan³

et al. 1997

Clinical and Experimental Immunology

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SUMMARYThe characteristic finding of autoantibodies in patients with vasculitis has raised the possibility that these antibodies play a role in the pathogenesis of the disease. The expression of adhesion molecules (AM) on leucocytes and endothelial cells is believed to be integral to the development of vasculitis. We therefore investigated the effect of sera, positive for anti-neutrophil cytoplasmic antibodies (ANCA) or anti-nuclear antibodies (ANA) from patients with vasculitis, on granulocyte expression of the adhesion molecule Mac-1 (CD11b). Autoantibody-positive sera from 15 out of 35 patients with vasculitis stimulated an up-regulation of Mac-1 on granulocytes. In most cases this effect was reproduced by the autoantibody-positive purified IgG fraction. Autoantibody-negative samples did not stimulate AM up-regulation. Of interest, preincubation of sera with purified antigens did not inhibit AM up-regulation by the autoantibody samples. Blocking the Fc receptors on granulocytes did result in a decrease of Mac-1 up-regulation, but this trend was not statistically significant. These results suggest that both ANCA and ANA have the capacity to up-regulate granulocyte AM expression, and that while Fc interaction with granulocyte Fc receptors is important, it is not the only mechanism whereby such autoantibodies activate cells.

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Association between active Wegener's granulomatosis and anticytoplasmic antibodies

Cited by 262 publications

References 0 publications

Antineutrophil cytoplasmic antibodies in rheumatoid arthritis. characterization and clinical correlations

Antineutrophil cytoplasmic antibodies in rheumatoid arthritis. characterization and clinical correlations

Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long‐term followup study

Up-regulation of the granulocyte adhesion molecule Mac-1 by autoantibodies in autoimmune vasculitis

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