Association between acute kidney injury and risk of Parkinson disease

Lin, Shih Yi; Lin, Cheng Li; Hsu, Wu Huei; Yeh, Hung Chieh; Lin, Cheng Chieh; Lin, Chi-Yi; Tseng, Chun Hung

doi:10.1016/j.ejim.2016.09.016

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…Previously, the association between chronic renal dysfunction and proteinuria with the incidence of PD was not widely studied. Some studies only focused on examining acute‐stage renal dysfunction . Two recent cohort studies reported that chronic renal dysfunction might be related to the risk of occurrence of parkinsonism.…”

Section: Discussionmentioning

confidence: 99%

Chronic renal dysfunction, proteinuria, and risk of Parkinson's disease in the elderly

et al. 2019

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Background The roles of chronic kidney disease and proteinuria in the development of Parkinson's disease have not been widely studied. The objective of this study was to examine the associations of chronic renal dysfunction and proteinuria with the risk of PD in older adults using cohort data of the whole South Korean population. Methods We included 3,580,435 individuals aged ≥65 years who had undergone health checkups provided by the National Health Insurance Service of South Korea between 2009 and 2012 and were followed until 2015. Multivariable Cox proportional hazards regression models were performed. Results During a mean follow‐up of 5.2 ± 1.3 years, 30,813 individuals (0.86% of the total population) developed PD. Lower estimated glomerular filtration rate and a higher degree of proteinuria on a dipstick test were associated with higher incidence probability of PD (log‐rank P < 0.001). In Cox regression models, chronic renal dysfunction graded by estimated glomerular filtration rate (mL/min/1.73 m2) was associated with increased risk of PD after adjusting for potential confounding variables; hazard ratio (95% confidence interval) was 1.13 (1.10–1.17) for estimated glomerular filtration rate 60–90, 1.36 (1.31–1.42) for estimated glomerular filtration rate 30–60, and 1.47 (1.32–1.63) for estimated glomerular filtration rate <30 (P for trend <0.001). Proteinuria ≥1+ was also associated with increased risk of PD development (hazard ratio, 1.12; 95% confidence interval, 1.06–1.18). Coexistence of chronic kidney disease and proteinuria showed an increased hazard ratio of 1.33 (95% confidence interval, 1.23–1.45) for PD occurrence. Conclusions Our findings suggest that chronic renal dysfunction and dipstick‐positive proteinuria may be independent risk factors for the development of PD in older adults. © 2019 International Parkinson and Movement Disorder Society

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Section: Discussionmentioning

confidence: 99%

Chronic renal dysfunction, proteinuria, and risk of Parkinson's disease in the elderly

et al. 2019

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“…Disorders in these systems, especially the noradrenergic system, can produce autonomic disorders such as constipation (Zhang et al, 2015). There are also reports describing an association between PD and renal disorders and uremia (Ali et al, 1985;Lin et al, 2016). Our previous study showed that 6-OHDA induced Parkinsonism associates with the reduction in serum urate level (Sarukhani et al, 2018).…”

Section: Discussionmentioning

confidence: 95%

The serum level of cystatin C does not predict dopaminergic cell death in substantia nigra, evidence from 6-hydroxydopamine-induced animal model of Parkinson's disease

Golezari

Haghdoost-Yazdi

Minaei

2020

Physiol. Pharmacol.

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Introduction: Cystatin C (CysC) is an indicator of renal function, and has been recently reported that associates with neurodegenerative diseases. To investigate the role of this substance in Parkinson's disease (PD), we evaluated the association between serum levels of CysC and other markers of renal function with 6hydroxydopamine (6-OHDA) induced Parkinsonism in rat. Methods: The 6-OHDA was microinjected into the medial forebrain bundle by stereotaxic surgery. After behavioral tests, immunofluorescence and biochemical studies were carried out to determine the number of survived dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and striatal dopamine level. The blood samples were collected from the caudal vain and the heart of animals. CysC was measured using the enzyme-linked immunosorbent assay (ELISA) kits. Results: There was no difference in serum level of CysC between the 6-OHDA treated and control groups, as well as before and after the toxin in the 6-OHDA group. Also, no association was found between CysC and DA neuronal death in SNc or striatal dopamine level. In addition, there was no significant difference in serum levels of creatinine, urea and potassium ions between the control and 6-OHDA treated groups. Conclusion: Since the death of DA neurons in SNc is the main pathophysiological mechanism underlying in the development of both 6-OHDA induced Parkinsonism and PD in human being, CysC and other markers of renal function cannot reflect DA neuronal death and accordingly cannot use for early diagnosis of PD.

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Oxygen Sensing in Neurodegenerative Diseases: Current Mechanisms, Implication of Transcriptional Response, and Pharmacological Modulation

Rey

Messa

Maghraby

et al. 2023

Antioxidants & Redox Signaling

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Significance: Oxygen sensing is the fundamental process through which organisms respond to changes in oxygen levels. Complex networks exist allowing the maintenance of oxygen levels through the perception, capture, binding, transport and delivery of molecular oxygen. The brain extreme sensitivity to oxygen balance makes the dysregulation of related processes crucial players in the pathogenesis of neurodegenerative diseases. Here we wish to review the most relevant advances in oxygen sensing in relation to Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis. Recent Advances: Over the years, it has been clarified that most neurodegenerative diseases share common pathways, a great number of which are in relation to oxygen imbalance. These include hypoxia, hyperoxia, ROS production, metabolism of metals, protein misfolding and neuroinflammation. Critical Issues: There is still a gap in knowledge concerning how oxygen sensing plays a role in the above indicated neurodegenerations. Specifically, oxygen concentrations are perceived in body sites which are not limited to the brain, but primarily reside in other organs. Moreover, the mechanisms of oxygen sensing, gene expression and signal transduction seem to correlate with neurodegeneration but many aspects are mechanistically still unexplained. Future Directions: Future studies should focus on the precise characterization of oxygen levels disruption and oxygen sensing mechanisms in neurodegenerative diseases.Moreover, advances need to be made also concerning the techniques used to assess oxygen sensing dysfunctions in these diseases. There is also the need to develop innovative therapies targeting this precise mechanism rather than its secondary effects, as early intervention is necessary.

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Association between acute kidney injury and risk of Parkinson disease

Cited by 4 publications

References 32 publications

Chronic renal dysfunction, proteinuria, and risk of Parkinson's disease in the elderly

Chronic renal dysfunction, proteinuria, and risk of Parkinson's disease in the elderly

The serum level of cystatin C does not predict dopaminergic cell death in substantia nigra, evidence from 6-hydroxydopamine-induced animal model of Parkinson's disease

Oxygen Sensing in Neurodegenerative Diseases: Current Mechanisms, Implication of Transcriptional Response, and Pharmacological Modulation

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