Association between ADIPOQ gene variants and knee osteoarthritis in a Chinese population

Abstract

A study from Thailand showed no significant association between the adiponectin (ADIPOQ) gene rs1501299 polymorphism and knee osteoarthritis (OA) risk. To investigate this association in a Chinese population, we conducted this case–control study involving 372 knee OA patients and 453 controls. Genotyping via standard PCR and restriction fragment length polymorphism (PCR-RFLP) showed that TT genotype (TT vs. GG: adjusted odds ratio (OR) (95% confidence interval (CI)) = 1.70 (1.01–2.86)) or T allele (T vs. G: adjusted OR (95% CI) = 1.26 (1.02–1.56)) of ADIPOQ gene rs1501299 polymorphism significantly increased the risk of knee OA. Significant associations were also observed in subgroups ≥55 years (TT vs. GG: adjusted OR (95% CI) = 2.21 (1.00–4.86)) and body mass index (BMI) < 25 kg/m2 (TT+GT vs. GG: adjusted OR (95% CI) = 1.53 (1.03–2.29)), but not in the subgroup analysis of sex. In conclusion, the ADIPOQ gene rs1501299 polymorphism intensifies the risk of knee OA in this Chinese Han population. Nevertheless, further studies with larger sample sizes in other populations are warranted to verify this finding.

Associations Between Adipokines Gene Polymorphisms and Osteoarthritis: a Meta-analysis

“…Two studies conducted by Honsawek et al from Thailand also found no association between ADIPOQ rs2241766 or rs1501299 polymorphism and the risk of knee OA [24,25]. However, another two studies focusing on the Chinese population reported significant associations between ADIPOQ rs2241766 and rs1501299 polymorphisms and an increased risk of knee OA [21,26]. The conflicting findings from the studies above might be attributed to three reasons.…”

“…1 shows a flow chart that illustrates the selection process. A total of 13 publications (7 on ADIPOQ polymorphism, 4 on LEPR polymorphism, 2 on LEP polymorphism, 2 on RESISTIN polymorphism, and 1 on VISFATIN polymorphism) containing 3,661 OA patients and 4,864 controls were included [21][22][23][24][25][26][27][28][29][30][31][32][33]. Table 1 details the characteristics of the included studies.…”

“…This milestone study initiated the journey to examine adipokines as a metabolic link between obesity and OA. Several SNPs of the adipokines genes have been associated with OA [21][22][23][24][25][26][27][28][29][30][31][32][33], however, the results are inconsistent. For instance, a study from Thailand rejected any significant association between the ADIPOQ gene rs1501299 polymorphism and knee OA [24], while Jin et al reported that rs1501299 polymorphism intensified the risk of knee OA in Chinese subjects [21].…”

“…Several SNPs of the adipokines genes have been associated with OA [21][22][23][24][25][26][27][28][29][30][31][32][33], however, the results are inconsistent. For instance, a study from Thailand rejected any significant association between the ADIPOQ gene rs1501299 polymorphism and knee OA [24], while Jin et al reported that rs1501299 polymorphism intensified the risk of knee OA in Chinese subjects [21]. In view of the limitations of individual studies and the inconsistency among different studies, we intended to clarify whether there were associations between the main types of adipokines gene SNPs and the susceptibility to OA through meta-analysis.…”

Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect

“…At present, many genes are reported to be related to the occurrence and development of OA by increasing susceptibility, enhancing cartilaginous matrix degradation, preventing cartilage from repair, increasing the expression of inflammatory factors, or promoting fibroblast transformation. First, the susceptibility genes of OA mainly include ASPN ( Wang et al, 2018 ), ADIPOQ ( Shang et al, 2019 ), AKNA ( Zhao et al, 2020a ), DPEP1 ( Zhang et al, 2021a ), rs1065080 ( Lu et al, 2019a ), TLR7 ( Wang et al, 2020a ), RTP4 ( Wang et al, 2020a ), CRIP1 ( Wang et al, 2020a ), ZNF688 ( Wang et al, 2020a ), TOP1 ( Wang et al, 2020a ), EIF1AY ( Wang et al, 2020a ), RAB2A ( Wang et al, 2020a ), ZNF281 ( Wang et al, 2020a ), UIMC1 ( Wang et al, 2020a ), and PRKACB ( Zhao, 2021 ). Second, the genes that promote the degradation of cartilage mainly include ADAMTS5 ( Jiang et al, 2021 ), ADAM12 ( Lv et al, 2017 ), JUN ( Rhee et al, 2017 ), PTGS2 ( Zhou et al, 2019a ), MMP1 ( Zhou et al, 2019a ), MMP3 ( Zhou et al, 2019a ), MMP13 ( Zhou et al, 2019a ), AGT ( Wang et al, 2020b ), and rs2830585 ( Zhou et al, 2019b ).…”