Association between affective temperaments and mood features in bipolar disorder II: The role of insomnia and chronobiological rhythms desynchronization

Palagini, Laura; Caruso, Danila; Massa, Lucia; Novi, Martina; Pardini, F.; Salarpi, Gianluca; Pini, Stefano; Marazziti, Donatella; Étain, Bruno; Riemann, Dieter

doi:10.1016/j.jad.2020.01.134

Cited by 14 publications

(11 citation statements)

References 64 publications

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“…As we have known, many observational studies aim to explore the associations between insomnia and BD, MDD, and SCZ. A case–control study found that insomnia significantly affected patients with BP with depressive symptoms (OR = 4.17, p = 0.043), and sleep disturbances also predicted manic symptoms (OR = 8.69, p = 0.001) ( Palagini et al, 2020 ). Integrating 21 observational studies for insomnia on DP, Baglioni et al show that the overall OR of insomnia is 2.60 ( Baglioni et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

The Causal Effects of Insomnia on Bipolar Disorder, Depression, and Schizophrenia: A Two-Sample Mendelian Randomization Study

et al. 2021

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Psychiatric disorder, including bipolar disorder (BD), major depression (MDD), and schizophrenia (SCZ), affects millions of persons around the world. Understanding the disease causal mechanism underlying the three diseases and identifying the modifiable risk factors for them hold the key for the development of effective preventative and treatment strategies. We used a two-sample Mendelian randomization method to assess the causal effect of insomnia on the risk of BD, MDD, and SCZ in a European population. We collected one dataset of insomnia, three of BD, one of MDD, and three of SCZ and performed a meta-analysis for each trait, further verifying the analysis through extensive complementarity and sensitivity analysis. Among the three psychiatric disorders, we found that only insomnia is causally associated with MDD and that higher insomnia increases the risk of MDD. Specifically, the odds ratio of MDD increase of insomnia is estimated to be 1.408 [95% confidence interval (CI): 1.210–1.640, p = 1.03E-05] in the European population. The identified causal relationship between insomnia and MDD is robust with respect to the choice of statistical methods and is validated through extensive sensitivity analyses that guard against various model assumption violations. Our results provide new evidence to support the causal effect of insomnia on MDD and pave ways for reducing the psychiatric disorder burden.

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Section: Discussionmentioning

confidence: 99%

The Causal Effects of Insomnia on Bipolar Disorder, Depression, and Schizophrenia: A Two-Sample Mendelian Randomization Study

et al. 2021

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“…This scale contains 21 items designed to assess five domains related to biological rhythms: (1) Sleep, (2) Activities, (3) Social aspects, (4) Alimentation, based on the last 15 days, and (5) predominant Rhythm (chronotype) based on the last year. The total score may range from 16 to 84, with the higher the score obtained, the greater the alteration of the biological rhythms ( 64 ).…”

Section: Methods and Analysismentioning

confidence: 99%

“…5) predominant Rhythm (chronotype) based on the last year. The total score may range from 16 to 84, with the higher the score obtained, the greater the alteration of the biological rhythms (64).…”

Section: Clinical Symptomatologymentioning

confidence: 99%

Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program

et al. 2020

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Introduction: Recent studies have shown that symptoms of psychiatric illness, functionality, and cognitive function improve with exercise. The aim of this study will be to investigate whether the implementation of an individualized exercise program will improve the functional status of patients with bipolar disorder (BD). Methods: This longitudinal, interventional, randomized, controlled, simple-blind clinical trial will include 80 patients aged 18–65 years, all of them with BD diagnosis. Patients will be randomly assigned to a physical exercise intervention + Treatment-As-Usual (TAU) group and a non-intervention + TAU group. Patients will be assessed by an extensive battery of clinical tests, physical parameters (e.g., brain structure changes measured by optical coherence tomography, cardiorespiratory fitness) and biological parameters (inflammation, oxidative stress and neurotrophic factors) at baseline, after a 4-month intervention period, and 6-month follow-up. Discussion: This is an innovative study aimed at gaining a deeper understanding of the physiopathology of BD and determining whether the prognosis and evolution of the disease can be improved through modifiable areas of the patient's lifestyle. Clinical Trial Registration: NCT04400630. NCT clinicaltrials.gov . Date of registration in primary registry 22 May 2020. clinicaltrials.gov .

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“…Nonetheless, the self-rated version of MADRS has previous shown a high correlation with the clinician-rated scale (65,66). Moreover, ISI has been shown to be a valid and sensitive tool to detect changes in perceived sleep difficulties with treatment (30) and eligible for use in patients with affective disorders (67,68). Nevertheless, additional clinician-rated measures would have been interesting as discrepancy between subjective and objective severity of the depressive symptoms may have a predictive value in chronotherapeutic interventions (69).…”

Section: Limitationsmentioning

confidence: 99%

Total Sleep Deprivation Followed by Bright Light Therapy as Rapid Relief for Depression: A Pragmatic Randomized Controlled Trial

et al. 2021

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Background: Total sleep deprivation (TSD) combined with bright light therapy (BLT) has been suggested as a valuable add-on to standard treatment for rapid relief of depression. However, there is a lack of randomized controlled trials in real-life clinical settings. The aim of this pragmatic randomized clinical trial was to investigate the effectiveness, acceptance, and feasibility of TSD combined with BLT as add-on to standard treatment for depression in a real-life clinical setting.Methods: Thirty-three inpatients were randomly assigned to either: a) an intervention group receiving a single-night TSD followed by 6 days BLT (10.000 lux, 30 min/day) as add-on to standard treatment; or b) a control group receiving a short sleep-hygiene consultation in addition to standard treatment. The follow-up period was 1 week.Results: No statistical differences were found in response rates, reduction of depressive and insomnia symptoms, length of stay, readmission rate, and clinical improvement. Both groups reported positive experiences toward the received treatment with low drop-out rates.Conclusions: One-night TSD followed by BLT was not effective as a rapid relief for depression at 1-week follow-up; however, the treatment was feasible and well-tolerated.

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Association between affective temperaments and mood features in bipolar disorder II: The role of insomnia and chronobiological rhythms desynchronization

Cited by 14 publications

References 64 publications

The Causal Effects of Insomnia on Bipolar Disorder, Depression, and Schizophrenia: A Two-Sample Mendelian Randomization Study

The Causal Effects of Insomnia on Bipolar Disorder, Depression, and Schizophrenia: A Two-Sample Mendelian Randomization Study

Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program

Total Sleep Deprivation Followed by Bright Light Therapy as Rapid Relief for Depression: A Pragmatic Randomized Controlled Trial

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