Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults

Lu, Wan-Hsuan; Guyonnet, Sophie; Martinez, Laurent O.; Lucas, Alexandre; Parini, Angelo; Vellas, Bruno; de Souto Barreto, Philipe

doi:10.1007/s11357-023-00906-2

Cited by 9 publications

(2 citation statements)

References 45 publications

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“… 67 Some scholars found that plasma biomarkers of two hallmarks of aging (chronic inflammation and mitochondrial dysfunction) differentiated older adults with multi-impaired IC trajectories from those with high-stable IC. 64 The routine evaluation of biological age using measures such as IC could have provided a more comprehensive insight into the vulnerability and resilience of the individual.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have indicated that heightened levels of plasma inflammation biomarkers, including IL-6, CRP, TNFR-1, and GDF-15, have been linked to decreased IC or accelerated IC decline. 64 , 74 Chronic inflammation is the most convincing biomarker of frailty in the context of “inflammatory aging” so far. 75 However, research on anti-inflammatory treatments for improving IC is limited.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Global Research Trends on Intrinsic Capacity of Older Adults: A Bibliometric and Visual Analysis of Papers Published During 2015–2023

Cao,

Tian,

Chen

et al. 2024

JMDH

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Global Research Trends on Intrinsic Capacity of Older Adults: A Bibliometric and Visual Analysis of Papers Published During 2015–2023

Cao,

Tian,

Chen

et al. 2024

JMDH

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Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong

Rajasuriar,

Hisham,

Lim

et al. 2024

J Int AIDS Soc.

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IntroductionWHO's Integrated Care for Older People (ICOPE) proposes we measure the functional construct of intrinsic capacity (IC) to monitor and identify individuals with age‐associated vulnerabilities. Assessments of IC may be useful to address the evolving, non‐HV care needs of ageing people with HIV (PWH). However, to date, its utility within the context of HIV has not been assessed.MethodsParticipants included 200 PWH attending out‐patient care (2021−2023) in Universiti Malaya Medical Centre, Malaysia and 101 community controls aged 35 years and above. The ICOPE framework was adapted to derive aggregate IC scores (ranging 0–6) encompassing the five domains of cognition, sensory (hearing and vision), mobility, mood and vitality. Multivariable analyses were used to explore the association of IC scores in PWH with multiple health outcomes including frailty, difficulties performing instrumental activities of daily living (IADL) and inflammatory markers. Area under the receiver operator characteristic (AUC‐ROC) was calculated to predict frailty and IADL deficits in the current cohort and an independent cohort of 275 PWH from Hong Kong (HK).ResultsMedian (interquartile range, IQR) age among PWH and controls were 50 (42−56) and 50 (39−59) years, respectively. There were more males among PWH (83% vs. 56%, p<0.001). All PWH received antiretroviral therapy (ART) for a median duration of 11 (8−14) years. Aggregate IC scores were lower in PWH but not significantly different compared to controls, (5.4 vs. 5.6, p = 0.093) and PWH performed significantly worse than controls only in the cognitive domain. Aggregate IC scores in PWH was independently associated with frailty (OR 0.17 95% CI 0.07−0.42, p<0.001), IADL deficits (OR 0.25 95% CI 0.14−0.46, p<0.001) and all other patient‐reported outcomes assessed. Aggregate IC scores correlated with IL‐6 but not sCD14 and sCD163 levels. IC scores performed well in identifying PWH with frailty (AUC‐ROC ≥ 0.80) in the HK and Malaysian cohorts but more modestly (AUC‐ROC ≥ 0.64) for IADL deficits.ConclusionsIC is a good composite measure to monitor non‐HIV, age‐associated physical and social vulnerabilities in PWH on ART and should complement disease‐based monitoring in routine HIV care. Assessments of IC should be validated in larger, longitudinal cohorts of PWH from diverse settings.

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Invariances in relations between aging, exposure to external hazards, and mortality reflected in life table aging rate (LAR) patterns examined through the lens of generalized Gompertz–Makeham law

Golubev

2024

Biogerontology

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Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults

Cited by 9 publications

References 45 publications

The Global Research Trends on Intrinsic Capacity of Older Adults: A Bibliometric and Visual Analysis of Papers Published During 2015–2023

The Global Research Trends on Intrinsic Capacity of Older Adults: A Bibliometric and Visual Analysis of Papers Published During 2015–2023

Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong

Invariances in relations between aging, exposure to external hazards, and mortality reflected in life table aging rate (LAR) patterns examined through the lens of generalized Gompertz–Makeham law

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