Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis

Mao, Ning; Nie, Siyao; Hong, Bin; Li, Chao; Shen, Xueyuan; Xiong, Tao

doi:10.1186/s12957-016-0937-y

Cited by 12 publications

(8 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In people with ADH1B His/His, the activity of ADH1B is enhanced, followed by rapid accumulation of acetaldehyde 25 . In epidemiological studies, ADH1B polymorphism has been associated with tumors of the upper digestive organs 4 including esophageal cancer 26 . In terms of breast cancer, ADH1B itself did not present any association in most previous studies 19,27,28 .…”

Section: Discussionmentioning

confidence: 99%

Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women

Park

Kim

Lee

et al. 2020

Sci Rep

View full text Add to dashboard Cite

the associations between genetic polymorphisms in ADH1B (rs1229984) and ALDH2 (rs671), alcohol consumption, the effect of a combination of the two polymorphisms, and breast cancer risk were studied in a population of East-Asian women. In this study, 623 breast cancer cases and 1845 controls, aged 40 or above, were included. The association between ALDH2 polymorphism and breast cancer risk was validated in 2143 breast cancer cases and 3977 controls. Alcohol consumption increased the risk of breast cancer regardless of ADH1B and ALDH2 genotypes. The rs671 polymorphism of ALDH2 was independently associated with increased breast cancer risk (oR = 1.27, 95% CI = 1.02-1.58 per increment of A). The ADH1B rs1229984 polymorphism, and combined effects of the rs671 and rs1229984 polymorphisms, did not reveal any significant association with breast cancer. Stratification by menopausal status revealed that rs671 gene polymorphisms were significantly associated with breast cancer only in postmenopausal women (oR = 1.45, 95% CI = 1.03-2.05 per increment of A). This is the first study to demonstrate an independent association between ALDH2 gene variants and breast cancer in Asian women. further studies are warranted to further elucidate the etiology of breast cancer as it relates to alcohol consumption in Asian women. open Scientific RepoRtS | (2020) 10:6564 | https://doi.population 12 , new studies exploring the associations and interactions among alcohol consumption, related ethanol-metabolizing genes, and breast cancer are warranted. Thus, in the present study, we investigated the association among genetic, functionally established single nucleotide polymorphisms (SNPs) in ADH1B (rs1229984) and ALDH2 (rs671), alcohol consumption, and their combined effects and breast cancer risk in an East-Asian population. Scientific RepoRtS |(2020) 10:6564 | https://doi. Statistical analysis.The relationship between alcohol consumption and breast cancer risk was assessed with a simple logistic regression and a multiple logistic regression adjusted for age at menarche, age at first full term pregnancy, age at menopause, body mass index, smoking status, and rs671/rs1229984 genotype. The relationship between rs671 genotype, rs1229984 genotype, and breast cancer risk was additionally assessed with a simple and a multiple logistic regression adjusted for age at menarche, age at first full term pregnancy, age at menopause, body mass index, smoking status, and alcohol consumption. To assess the association between each SNP and breast cancer, the codominant, dominant, and additive models were considered. In addition, the combined effects of rs671 and rs1229984 genotype on breast cancer were assessed. The ALDH2 and ADH1B genotypes and alcohol intake status were collectively studied to evaluate their combined effect on breast cancer risk. Stratified by ALDH2, ADH1B, and a combination of ALDH2/ADH1B genotypes, the association among alcohol consumption itself, daily alcohol intake, and breast cancer was evaluated with odds ratio (OR) and P-value. In ad...

show abstract

Section: Discussionmentioning

confidence: 99%

Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women

Park

Kim

Lee

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Evidence regarding the effect of rs1229984 on specific cancer risk has been contradictory. SNP presence may confer increased risk, decreased risk or no association cancer risk (31), whilst others argue the variant confers increased risk (32)(33)(34). As mentioned prior, the mechanism of how this variant may affect cancer risk is poorly understood but may be due to altered enzymatic function of ADH1B in individuals with rs1229984 (6).…”

Section: Crude or A Adjusted Or B -----------------------------------mentioning

confidence: 99%

Association between rs1229984 in ADH1B and cancer prevalence in a Japanese population

et al. 2020

View full text Add to dashboard Cite

Alcohol consumption is an established risk factor for cancer, but little is known regarding the effect of genetic polymorphisms in alcohol metabolism genes on alcohol-related cancer risk in the Japanese population. Associations between the ADH1B gene (alcohol dehydrogenase 1B), single nucleotide polymorphism (SNP) rs1229984 and cancer have been extensively studied yet evidence is inconsistent. This population-based case-control study primarily aimed to clarify any association between SNP rs1229984 in both overall and specific cancer risk in a Japanese population. The functional non-synonymous SNP rs1229984 (Arg48His) was genotyped using DNA samples from 1,359 consecutive autopsy cases registered in The Japanese Single Nucleotide Polymorphisms for Geriatric Research database. Medical and pathological record data from this database were used to categorise cases and controls. Results included 1,359 participants, 816 cases and 543 controls. Multinomial logistic regression analyses showed no significant association between rs1229984 presence and overall cancer risk in both dominant and recessive genetic inheritance models [Arg/Arg+Arg/His vs. His/His: Adjusted odds ratio (OR)=0.66 (95% CI=0.39-1.13; P=0.129), Arg/Arg vs. Arg/His+His/His: OR=0.95 (95% CI=0.75-1.20; P=0.657)]. However, results showed those homozygous for rs1229984 (genotype His/His) were at significantly decreased odds of lung cancer than other genotypes [recessive model: OR=0.64 (95% CI=0.44-0.93; P=0.020]. In conclusion, there was no significant association between rs1229984 and odds of overall or specific cancers except in lung cancer where His/His genotype decreased odds. To the best of our knowledge, the association between His/His and decreased odds of lung cancer is a novel finding. These findings require further validation in larger studies.

show abstract

“…However, the findings are as yet inconclusive. Several meta-analyses published before 2016 associated this polymorphism only with esophageal, head and neck, gastric, colorectal, and upper aerodigestive tract cancer [11–16]. However, no meta-analyses have ever investigated the association between ADH1B Arg47His polymorphism and overall cancer risk, including other types of cancer.…”

Section: Introductionmentioning

confidence: 99%

Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis

Tan

Ning

2019

Bioscience Reports

View full text Add to dashboard Cite

Alcohol consumption has been established to be a major factor in the development and progress of cancer. Genetic polymorphisms of alcohol-metabolism genes result in differences between individuals in exposure to acetaldehyde, leading to possible carcinogenic effects. Arg47His (rs1229984 G > A) in ADH1B have been frequently studied for its potential effect on carcinogenesis. However, the findings are as yet inconclusive. To gain a more precise estimate of this potential association, we conducted a meta-analysis including 66 studies from 64 articles with 31999 cases and 50964 controls. The pooled results indicated that ADH1B Arg47His polymorphism is significantly associated with the decreased risk of overall cancer (homozygous model, odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.49–0.77; heterozygous model, OR = 0.71, 95% CI = 0.60–0.84; recessive model, OR = 0.83, 95% CI = 0.76–0.91; dominant model, OR = 0.62, 95% CI = 0.53–0.72; and allele comparison, OR = 0.82, 95% CI = 0.75–0.89). Stratified analysis by cancer type and ethnicity showed that a decreased risk was associated with esophageal cancer and head and neck cancer amongst Asians. In conclusion, our meta-analysis suggested that ADH1B Arg47His polymorphism was significantly associated with decreased overall cancer risk. These findings need further validation in large multicenter investigations.

show abstract

Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis

Cited by 12 publications

References 66 publications

Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women

Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women

Association between rs1229984 in ADH1B and cancer prevalence in a Japanese population

Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis

Contact Info

Product

Resources

About