Association between allergic diseases, allergic sensitization and attention-deficit/hyperactivity disorder in children: A large-scale, population-based study

Yang, Chia‐Feng; Wang, I-Jen

doi:10.1016/j.jcma.2017.07.016

Cited by 40 publications

(40 citation statements)

References 37 publications

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“…ADHD is associated with allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. The immune response to these allergic diseases are known to increase the risk of neurodevelopmental diseases by affecting the central nervous system (37,38). In a study about allergic disease and inflammation in ADHD, allergic diseases, Ig-E and eosinophil levels were higher in the ADHD group (39).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

Aksu

Dağ

2020

Düzce Tıp Fakültesi Dergisi

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Aim: It was aimed to evaluate the hematological inflammatory markers in treatment-naive and comorbidity-free children and adolescents with attention deficit and hyperactivity disorder (ADHD) in this study. Material and Methods: One hundred sixty-nine children aged 6-18, who were diagnosed with ADHD according to DSM-5 criteria were included in the study. Age and sex-matched 59 healthy children without any psychiatric and/or medical disorder were included as a control group. The children who had an intellectual disability and/or autism spectrum disorder, acute, chronic or inflammatory diseases were excluded from the study. Smoking, obesity and using psychotropic medications and lack of data in records were other exclusion criteria. ADHD and control groups were compared in terms of sociodemographic characteristics, inflammatory markers and hematological parameters. Results: Mean platelet volume (MPV) and Basophil (BASO) levels were significantly higher in the ADHD group compared to the control group and this statistical difference was only observed for boys. In hyperactivity subtype, red cell distribution width (RDW), lymphocyte (LYMPH) and monocytes (MONO) were higher; in attention deficit subtype mean platelet volume-to-lymphocyte ratio (MPVLR) was higher than all other subtypes and control group. MPV was similar in three subtypes, and were higher in all of them than the control group. Conclusion: This study revealed that MPV and BASO tend to be higher in the ADHD group especially in boys. Hematological biomarkers may be useful for diagnosis of ADHD and determination of ADHD subtypes but data on this subject are insufficient and more comprehensive studies are needed.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

Aksu

Dağ

2020

Düzce Tıp Fakültesi Dergisi

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“…We generated regression models with additional adjustment for maternal smoking during pregnancy, 29 maternal alcohol consumption during pregnancy, 30 breastfeeding, 31 preterm birth, 32 birth weight, 33 and number of siblings 34 to assess those associations with ADHD symptoms. Finally, we excluded children with allergic diseases (defined as having physician-diagnosed eczema, allergic conjunctivitis, and/or asthma), 35 congenital heart diseases, 36 preterm birth, 32 or low birth weight (defined as birth weight <2500 g) 33 as a group potentially with greater baseline risk for ADHD.…”

Section: Discussionmentioning

confidence: 99%

Association Between Greenness Surrounding Schools and Kindergartens and Attention-Deficit/Hyperactivity Disorder in Children in China

et al. 2019

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IMPORTANCE Few studies have investigated the association between greenness and childhood attention-deficit/hyperactivity disorder (ADHD). OBJECTIVE To evaluate the association between greenness surrounding schools or kindergartens and symptoms of ADHD in children. DESIGN, SETTING, AND PARTICIPANTS This population-based cross-sectional study was performed between April 2012 and January 2013 in 7 cities in northeastern China. This analysis included 59 754 children (aged 2-17 years) from 94 schools and kindergartens, who had resided in the study area for 2 years or longer. Data were analyzed from April 15, 2019, to October 10, 2019. EXPOSURES Greenness surrounding each child's school or kindergarten was estimated using 2 satellite image-derived vegetation indexes: the normalized difference vegetation index and the soiladjusted vegetation index. MAIN OUTCOMES AND MEASURES Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) scales were used to measure ADHD symptoms (9 inattention symptoms and 9 hyperactivityimpulsivity symptoms). Parents or guardians rated the frequency of each of 18 ADHD symptoms during the preceding 6 months. Children with 6 or more symptoms of either inattention or hyperactivity-impulsivity were defined as having ADHD symptoms. Generalized linear mixed models were applied to estimate the association between greenness and ADHD symptoms. RESULTS The mean (SD) age of the 59 754 study participants was 10.3 (3.6) years, and 29 494 (49.4%) were girls. A total of 2566 participants (4.3%) had ADHD symptoms. Greenness levels differed substantially across schools and kindergartens. The normalized difference vegetation index within 500 m of a school or kindergarten ranged from −0.09 to 0.77. Greater greenness levels were associated with lower odds of ADHD symptoms. In covariate-adjusted models, a 0.1-unit increase in normalized difference vegetation index or soil-adjusted vegetation index within 500 m of a school or kindergarten was significantly associated with lower odds of ADHD symptoms (odds ratios, 0.87 [95% CI, 0.83-0.91] and 0.80 [95% CI, 0.74-0.86], respectively; P < .001 for both). The associations were robust in a series of sensitivity analyses. CONCLUSIONS AND RELEVANCE These findings suggest that there may be a beneficial association between school-based greenness and ADHD symptoms in Chinese children. Future longitudinal and mechanistic studies are needed to confirm the findings of this cross-sectional analysis and further explore potential mechanisms of this association.

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“…On the other hand, no association of this IL-1RN polymorphism with ADHD was found in a larger sample [41]. Comorbidity with allergic and autoimmune disorders such as atopic eczema, allergic rhinitis and asthma is another factor that could increase the risk for ADHD and future research may lead to a better understanding of the mechanisms underlying the observed comorbidity [38,[42][43][44]. In a meta-analysis and a large-scale genome-wide association study (GWAS), associations between asthma and ADHD were found in both children and adults [45,46].…”

Section: Inflammation and The Relationship With Adhdmentioning

confidence: 95%

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

et al. 2020

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Psychostimulants and non-psychostimulants are the medications prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, several adverse results have been linked with an increased risk of substance use and side effects. The pathophysiology of ADHD is not completely known, although it has been associated with an increase in inflammation and oxidative stress. This review presents an overview of findings following antioxidant treatment for ADHD and describes the potential amelioration of inflammation and oxidative stress using antioxidants that might have a future as multi-target adjuvant therapy in ADHD. The use of antioxidants against inflammation and oxidative conditions is an emerging field in the management of several neurodegenerative and neuropsychiatric disorders. Thus, antioxidants could be promising as an adjuvant ADHD therapy.

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Association between allergic diseases, allergic sensitization and attention-deficit/hyperactivity disorder in children: A large-scale, population-based study

Abstract: Our results suggest that AD and asthma with allergic sensitization are associated with ADHD in children. As allergic sensitization is an increased factor of developing allergic diseases, early control of environmental and allergens exposure could help to modify the burden of ADHD.

Cited by 40 publications

References 37 publications

Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

Association Between Greenness Surrounding Schools and Kindergartens and Attention-Deficit/Hyperactivity Disorder in Children in China

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

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