Association between alopecia areata, anxiety, and depression: A systematic review and meta-analysis

Okhovat, Jean-Phillip; Marks, Dustin H.; Manatis-Lornell, Athena; Hagigeorges, Dina; Locascio, Joseph J.; Senna, Maryanne M.

doi:10.1016/j.jaad.2019.05.086

Cited by 95 publications

(92 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence of major depression in patients with AA has been reported as 8.8% compared with 1.3-1.5% in the general population, and generalized anxiety disorder has been reported in 18.2% compared with 2.5%, respectively [1]. Although psychiatric diagnoses preceded AA in approximately half the patients, in other patients AA appears to contribute to the development of depression and anxiety [1,3].…”

Section: Introductionmentioning

confidence: 99%

Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review

Mostaghimi

Napatalung

Sikirica

et al. 2021

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Introduction: Alopecia areata (AA) is a chronic, autoimmune disease of hair loss, which can significantly affect the emotional and psychological well-being of patients. A systematic literature review was conducted to better understand the burden of AA from the patient perspective. Methods: Embase, MEDLINE and Cochrane databases were searched for published studies (2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018) reporting on assessments of health-related quality of life (HRQoL) for patients with AA. Qualitative, and quantitative data were collected. Results: The review included 37 studies encompassing a range of clinical outcome assessment (COA) tools. None of the COA tools were specific for AA, and only one study used the Hairdex scale, which was designed to evaluate HRQoL in patients with disorders of the hair and scalp. All studies reported substantial impact on HRQoL due to AA, both overall and in domains related to personality (i.e. temperament and character), emotions and social functioning. Acute stress was also noted, and several studies identified lack of emotional awareness (alexithymia) in 23-50% of the patients with AA. Conclusions: Although it is well-established that patients with AA experience anxiety and depression, they also experience a decrease in HRQoL in many other areas, including personality, emotions, behaviors and social functioning, and these changes may be accompanied by acute stress and alexithymia. There is a need to achieve consensus on a core set of measures for AA and to develop and validate AA-specific measurement tools for use in future studies, to attain a clearer understanding of the impact of AA on patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review

Mostaghimi

Napatalung

Sikirica

et al. 2021

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

show abstract

“…Shanice A. MCKENZIE, 1 Fritzlaine C. ROCHE, 2,3 Ginikanwa ONYEKABA, 3 Devin M. WILLIAMS, 2 Temitayo A. OGUNLEYE, 4 Susan C. TAYLOR 4…”

Section: Conflict Of Interest: None Declaredmentioning

confidence: 99%

Comorbid anxiety and depression among black women with central centrifugal cicatricial alopecia: A retrospective study

et al. 2020

View full text Add to dashboard Cite

The published work suggests a higher risk for anxiety and depression among patients with alopecia areata (AA), 1 but less is known about central centrifugal cicatricial alopecia (CCCA), a primary scarring alopecia. CCCA occurs predominantly in black women, with a prevalence of 2.7-5.7%. 2 In a previous study, CCCA was strongly associated with low quality of life. 3 However, the psychiatric comorbidity burden among patients with CCCA has not been explored. We aimed to assess the risk of comorbid depression and anxiety among black female patients with CCCA compared with patients with AA and psoriasis. In this cross-sectional study, the medical records of black female patients aged 18 years and older with a diagnosis of CCCA, psoriasis or alopecia areata seen in the Dermatology Department of Perelman School of Medicine between July 2017 and July 2019 were reviewed. This study received an exemption from the institutional review board of the University of Pennsylvania. International Classification of Diseases, 10th Revision codes included L40.0 (psoriasis vulgaris), L66.9 (CCCA), L63.9 (AA), F32.1 (major depressive disorder, single episode, moderate), F32.2 (major depressive disorder, single episode), F33.0 (major depressive disorder, recurrent, mild), F33.1 (major depressive disorder, recurrent, moderate), F32.2 (major depressive disorder, recurrent, severe) and F41.1 (generalized anxiety disorder). Data was collected on patient demographics, and patients with a concomitant diagnosis of anxiety or depression were identified. Descriptive statistics were calculated, P-values were calculated using a two-tailed v 2-test with Yates' correction, and odds ratios were calculated with 95% confidence intervals by Stata version 16 software (StataCorp, College Station, TX, USA). There were a total of 270 black women with a diagnosis of CCCA. Of these, 27 (10.0%) had a diagnosis of anxiety or depression in their medical records. In the same period, 84 black women with psoriasis and 69 black women with AA were identified. In these groups, anxiety or depression was accounted for in 10 (11.9%) patients with AA, alopecia areata; CI, confidence interval; CCCA, central centrifugal cicatricial alopecia; OR, odds ratio.

show abstract

“…The prevalence of AA ranges from 0.1% to 0.2%, while the lifetime risk of developing AA is approximately 2% 1,2 . As a disease causing significant disfigurement, AA, characterized by oval or patchy area of hair loss mainly on the scalp, imposes a significant psychosocial burden on affected individuals 3‐5 . Although several therapies are available, the treatment for extensive AA remains challenging 6‐8 .…”

Section: Introductionmentioning

confidence: 99%

Bidirectional association between alopecia areata and atopic dermatitis: A population‐based cohort study in Taiwan

Wei

Tai

Dai

et al. 2020

Clin Experimental Allergy

View full text Add to dashboard Cite

Alopecia areata (AA) is a T cell-mediated autoimmune disease characterized by the sudden onset of hair loss without significant inflammation or scarring. The prevalence of AA ranges from 0.1% to 0.2%, while the lifetime risk of developing AA is approximately 2%. 1,2 As a disease causing significant disfigurement, AA, characterized by oval or patchy area of hair loss mainly on the scalp, imposes a significant psychosocial burden on affected individuals. 3-5 Although several therapies are available, the treatment for extensive AA remains challenging. 6-8 The exact cause of AA remains elusive, but it is believed that AA results from collapse of the immune privilege of the hair follicle, autoimmune-mediated hair follicle destruction and the up-regulation of inflammatory pathways. 9 Atopic dermatitis (AD) is a chronic inflammatory disease featured by recurrent pruritus, xerosis and dermatitis in typical anatomic sites. Although there is no cure for AD, many treatment modalities are effective in controlling the associated symptoms. 10-12 The pathogenesis of AD is multifactorial, including barrier dysfunction, alterations in

show abstract

Association between alopecia areata, anxiety, and depression: A systematic review and meta-analysis

Cited by 95 publications

References 25 publications

Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review

Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review

Comorbid anxiety and depression among black women with central centrifugal cicatricial alopecia: A retrospective study

Bidirectional association between alopecia areata and atopic dermatitis: A population‐based cohort study in Taiwan

Contact Info

Product

Resources

About