Association between ambient air pollution and pregnancy outcomes in patients undergoing in vitro fertilization in Shanghai, China: A retrospective cohort study

Shi, Wenming; Sun, Chunyan; Chen, Qiaoyu; Ye, Mingming; Niu, Jianing; Meng, Zhenzhen; Bükülmez, Orhan; Chen, Miaoxin; Teng, Xiaoming

doi:10.1016/j.envint.2021.106377

Cited by 35 publications

(11 citation statements)

References 42 publications

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“…There is inconsistent evidence of an association between air pollution and adverse pregnancy outcomes (stillbirth, preterm birth, low birth weight, and macrosomia). Still, several studies have suggested adverse pregnancy outcomes attributed to exposure to air pollution [ 92 , 93 , 94 ]. One plausible explanation is that maternal exposure to particulate matter may represent a critical risk factor for intrauterine inflammation, which could then impact the placenta's growth, development, and function [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

Climate change impacts on the health of South Asian children and women subpopulations - A scoping review

Tiwari

Tilstra

Campbell

et al. 2022

Heliyon

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Section: Discussionmentioning

confidence: 99%

Climate change impacts on the health of South Asian children and women subpopulations - A scoping review

Tiwari

Tilstra

Campbell

et al. 2022

Heliyon

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“…All patients received COS treatment and monitoring and underwent oocyte collection, all of which were performed as described in detail previously [ 21 , 22 ]. After follicular aspiration for approximately 4 to 6 h, oocytes were inseminated by conventional methods or ICSI, depending on sperm quality.…”

Section: Methodsmentioning

confidence: 99%

The impact of different endometrial preparation protocols on obstetric and neonatal complications in frozen-thawed embryo transfer: a retrospective cohort study of 3,458 singleton deliveries

Zhou

et al. 2022

Reprod Biol Endocrinol

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Background Frozen-thawed embryo transfer (FET) is thought to be associated with obstetric and neonatal complications after in vitro fertilization/intracytoplasmic single sperm injection (IVF/ICSI) treatment. The study aimed to determine whether the endometrial preparation protocol is an influencing factor for these complications. Methods We conducted a retrospective cohort study of 3,458 women who had singleton deliveries after IVF/ICSI–FET treatment at the Centre for Reproductive Medicine of Shanghai First Maternity and Infant Hospital between July 2016 and April 2021. The women were divided into three groups according to the endometrial preparation protocols: 2,029 women with programmed cycles, 959 with natural cycles, and 470 with minimal ovarian stimulation cycles. The primary outcomes were the incidence rates of obstetric and neonatal complications, namely, hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), intrahepatic cholestasis of pregnancy (ICP), placenta previa, preterm rupture of membranes (PROM), preterm delivery, postpartum haemorrhage, large for gestational age (LGA), small for gestational age (SGA), and macrosomia. Results After adjustments for confounding variables by multivariate logistic regression analysis, the results showed that programmed cycles had an increased risk of HDP (aOR = 1.743; 95% CI, 1.110–2.735; P = 0.016) and LGA (aOR = 1.269; 95% CI, 1.011–1.592; P = 0.040) compared with natural cycles. Moreover, programmed cycles also increased the risk of LGA (aOR = 1.459; 95% CI, 1.083–1.965; P = 0.013) but reduced the risk of SGA (aOR = 0.529; 95% CI, 0.348–0.805; P = 0.003) compared with minimal ovarian stimulation cycles. There were no significant differences between natural cycles and minimal ovarian stimulation cycles. Conclusions During IVF/ICSI–FET treatment, the risk of HDP and LGA was increased in women with programmed cycles. Therefore, for patients with thin endometrium, irregular menstruation or no spontaneous ovulation, minimal ovarian stimulation cycles may be a relatively safer option than programmed cycles.

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“…A retrospective study reported the exposure to PM 2.5 or PM 10 before the period of oocyte retrieval adversely affected pregnancy and live birth rates in the general population undergoing IVF (27). Another study from Shanghai by Shi found a higher exposure to PM 10 , NO 2 , and SO 2 was related to reduced pregnancy or live birth rates in general patients with IVF (28). However, contrary to these results, significant correlations of air pollutants with clinical pregnancy and live birth rates were not observed in patients with PCOS in this study.…”

Section: Clinical and Research Implicationsmentioning

confidence: 99%

Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome

Zhu

Cai

Guo

et al. 2022

Front. Public Health

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BackgroundRecently, the relationship between air pollution and reproductive outcomes has become a research focus. However, there is a lack of research on the relationship between air pollution and polycystic ovary syndrome (PCOS).MethodsThis is a retrospective cohort study included a total of 1,652 women with PCOS and 12,543 women without PCOS conducted from 1 January 2015 to 31 December 2019. The average daily concentration data of six air pollutants (PM2.5, PM10, O3, NO2, SO2, and CO) during different exposure windows were obtained. Generalized estimating equation models were used to evaluate the association of air pollution with pregnancy outcomes.ResultsAir pollutants were not found to have a significant association with pregnancy rates among patients with PCOS. However, each IQR increase in PM10 exposure during period 3 (embryo transfer to serum HCG test) was associated with the reduced clinical pregnancy rate (adjusted OR = 0.92, 95% CI: 0.84–0.99) for patients without PCOS. Patients without PCOS showed lower clinical pregnancy rates with increased exposure to NO2 during periods 2 (oocyte retrieval to embryo transfer) and 5 (start of gonadotropin medication to embryo transfer), with aORs and 95% CIs of 0.94 (0.88, 0.99) and 0.94 (0.88, 0.98), respectively. Each IQR increase in SO2 among patients without PCOS during periods 1 (start of gonadotropin medication to oocyte retrieval), 2, 5, and 6 (start of gonadotropin medication to serum HCG test) was related to a decrease in clinical pregnancy rate. For the live birth rate, no significant relationship was found between air pollutants, including PM2.5, PM10, SO2, NO2, CO, and O3, and the live birth rate for women with PCOS. However, women without PCOS presented a lower probability of live birth with exposure to SO2 during periods 1, 2, 5, and 6.ConclusionThis retrospective study of reproductive-aged women observed no significant relationships between ambient pollutants and pregnancy outcomes among women with PCOS but found negative associations among women without PCOS.

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Association between ambient air pollution and pregnancy outcomes in patients undergoing in vitro fertilization in Shanghai, China: A retrospective cohort study

Cited by 35 publications

References 42 publications

Climate change impacts on the health of South Asian children and women subpopulations - A scoping review

Climate change impacts on the health of South Asian children and women subpopulations - A scoping review

The impact of different endometrial preparation protocols on obstetric and neonatal complications in frozen-thawed embryo transfer: a retrospective cohort study of 3,458 singleton deliveries

Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome

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