Association between amniotic fluid evaluation and fetal biometry: a prospective French “Flash” study

Fuchs, Florent; Aouinti, Safa; Souaied, Manel; Keller, Valentin; Picot, Marie‐Christine; Fries, N.; Ayoubi, Jean-Marc; Picone, Olivier

doi:10.1038/s41598-018-25497-3

Cited by 5 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another possibility is that more fetal movements might increase muscle volume and bone density, which lead to fetal weight gain. Moreover, bigger fetuses tend to have more amniotic fluid volume, 9,10 which might lead to more space for gross movement.…”

Section: Discussionmentioning

confidence: 99%

Correlation between newborn size and gross fetal movement as counted by a fetal movement acceleration measurement recorder

Yatsuki

Ryo

Morita

et al. 2020

J Dev Orig Health Dis

View full text Add to dashboard Cite

The development of the fetal movement acceleration measurement (FMAM) recorder has enabled the accurate counting of gross fetal movements. The aim of the study was to investigate whether gross fetal movement is related to a newborn’s size. A total of 90 pregnant women who delivered singleton infant at term were recruited. Gross fetal movements were counted using an FMAM recorder during maternal sleep. The ratio of movement positive 10-s epochs to all epochs during one night was calculated as an index of fetal movement. Independent explanatory variables for the fetal movement index were selected from eight possibilities, that is, maternal age, gestational week, and the six physical measures of the newborn (height, weight, head circumference, chest circumference, Kaup index, and the ratio of head to chest circumference) with the stepwise regression procedure. The selected physical variables and the fetal movement index were analyzed using multiple regression analysis. A total of 2812.95 h from 423 night records were available. Gestational weeks and weight of the newborn were selected as the significant independent variables. Multiple regression analysis revealed that newborn weight had a positive correlation with the fetal movement index (p < 0.0001). The multiple regression equation was “The fetal movement index (%) = 34.9989−0.9088 × gestational weeks + 0.0033 × newborn weight (g).” A person’s physical ability and lifetime activity level may originate from fetal health. This study may provide a new way of looking at the Developmental Origins of Health and Disease theory.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation between newborn size and gross fetal movement as counted by a fetal movement acceleration measurement recorder

Yatsuki

Ryo

Morita

et al. 2020

J Dev Orig Health Dis

View full text Add to dashboard Cite

show abstract

DNA concentrations in amniotic fluid according to gestational age and fetal sex: data from 2573 samples

Gofin,

Svirsky,

Lavi Ben Atav

et al. 2024

Arch Gynecol Obstet

View full text Add to dashboard Cite

Purpose In some cases of prenatal genetic testing, an ample amount of fetal DNA is needed, to allow for parallel testing (conducting several genetic tests simultaneously). This study investigated the association between amniotic fluid DNA concentration and various factors. We aimed to define the required amount of amniotic fluid to be extracted in amniocentesis, to allow parallel testing throughout gestational weeks. Methods DNA concentration was analyzed from amniocentesis samples taken during the years 2016–2022. Sex association was also analyzed in postnatal whole blood samples from a separate cohort. Theoretical minimum volume of amniotic fluid needed to ensure enough DNA for chromosomal microarray analysis and exome sequencing was calculated. Results We focused our analysis on 2573 samples, which were taken during weeks 17–23 and 30–35. DNA concentrations increased from weeks 17 to 21, with relatively stable concentrations thereafter. Significantly higher DNA concentrations were seen in pregnancies of female fetuses. DNA concentrations in postnatal whole blood samples did not show this association. Across most weeks, the volume needed to extract 2 µg of DNA from 95% of the samples was about 34 ml. Conclusion DNA concentrations in amniotic fluid vary according to gestational age and are higher in pregnancies of female fetuses. This should be considered when determining the volume of fluid extracted and the timing of amniocentesis, with greater volumes needed in earlier stages of pregnancy.

show abstract

Predicting the fetal weight by ultrasonography for isolated polyhydramnios: Comparison of 14 formulas

Yılmaz Ergani,

Çakır,

Akay

et al. 2024

J of Obstet and Gynaecol

View full text Add to dashboard Cite

ObjectiveTo recalculate the estimated fetal weight (EFW) based on ultrasound measurements in patients complicated with isolated polyhydramnios, using 14 current formulas to observe which formula better predicts the EFW.MethodsThis study examined pregnant women who gave birth in the hospital between January 2015 and January 2020. Maximum vertical pocket (MVP) was classified as, mild, moderate, and severe polyhydramnios, and the patients' measurements were reanalyzed using 14 formulas. The estimation of birth weight (EBW) alongside observed birth weight (OBW) facilitated the computation of statistical indices, namely the mean absolute percentage error (MAPE) expressed as [(EBW – OBW)/OBW × 100], the mean percentage error (MPE) denoted as (EBW – OBW)/(OBW × 100), and their corresponding 95% confidence intervals.ResultsA total of 564 polyhydramnios patients were included in the study. When looking at the MAPE, the lowest rate (7.65) was found in the Hadlock 2 formula. Hadlock 1, Hadlock 3, and Shinozuka formulas demonstrated MAPE values most closely aligned with Hadlock 2. Weiner I and Thurnau were the formulas with the highest MAPE values. When the cut‐off values for MAPE were taken as 10%, 4/14 of the formulas (Weiner I–II, Vintzleos and Thurnau) gave results above 10%. Among 14 formulas, 3 (21.4%) had positive (sonographic overestimation) (Hadlock 3, Shinozuka, and Vintzleos) and the other 11 (78.6%) had negative MPE (sonographic underestimation).ConclusionThe Hadlock 2 formula had the lowest MAPE in predicting birth weight in patients with polyhydramnios, closely followed by the Hadlock 1, Hadlock 3, and Shinozuka formulas.

show abstract

Association between amniotic fluid evaluation and fetal biometry: a prospective French “Flash” study

Cited by 5 publications

References 32 publications

Correlation between newborn size and gross fetal movement as counted by a fetal movement acceleration measurement recorder

Correlation between newborn size and gross fetal movement as counted by a fetal movement acceleration measurement recorder

DNA concentrations in amniotic fluid according to gestational age and fetal sex: data from 2573 samples

Predicting the fetal weight by ultrasonography for isolated polyhydramnios: Comparison of 14 formulas

Contact Info

Product

Resources

About