Association between amount of dopamine and infections in extremely preterm infants

Hotta, Masashi; Hirata, Katsuya; Nozaki, Masatoshi; Mochizuki, Narutaka; Hirano, Shinya; Wada, Kazuko

doi:10.1007/s00431-020-03676-7

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…DA itself is notably a widely used therapeutic drug, especially in intensive care units, therefore understanding the immunomodulatory role of these key neurotransmitters is of extreme relevance considering the critical conditions of Pts that are typically treated with this drug or more in general the wide use of drugs acting on DR (e.g., antiparkinson drugs) used in the clinical setting. In this regard, it is important to note that the range of concentrations used in the clinical setting can have negative effects on immune functions as reported in preterm infants [57] or in other clinical conditions of systemic infection [58].…”

Section: Discussionmentioning

confidence: 99%

Dopaminergic inhibition of human neutrophils is exerted through D1‐like receptors and affected by bacterial infection

et al. 2022

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Dopamine (DA) affects immune functions in healthy subjects (HS) and during disease by acting on D1-like (D1 and D5) and D2-like (D2, D3 and D4) dopaminergic receptors (DR); however, its effects on human polymorphonuclear leukocytes (PMN) are still poorly defined. We investigated DR expression in human PMN and the ability of DA to affect cell migration and reactive oxygen species (ROS) production. Experiments were performed on cells from HS and from patients (Pts) with bacterial infections as well, during the acute phase and after recovery. Some experiments were also performed in mice knockout (KO) for the DRD5 gene. PMN from HS express both D1-like and D2-like DR, and exposure to DA results in inhibition of activation-induced morphological changes, migration and ROS production which depend on the activation of D1-like DR.

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Section: Discussionmentioning

confidence: 99%

Dopaminergic inhibition of human neutrophils is exerted through D1‐like receptors and affected by bacterial infection

et al. 2022

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“…They indicated that the nosocomial infection rates were related to both the duration of dopamine administration and the total dopamine dose. In addition, a retrospective study of extremely preterm infants demonstrated that the increased amount of dopamine was associated with infection (9). Furthermore, i n vivo and in vitro tests also confirmed that dopamine could affect the growth or virulence of certain bacteria (10, 11).…”

Section: Introductionmentioning

confidence: 99%

Dopamine promotesKlebsiella quasivariicolaproliferation and inflammatory response in the presence of macrophages

Yan

Cheng

et al. 2023

Preprint

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Klebsiella quasivariicola was a novel strain of Klebsiella species and had potential pathogenicity. Our previously studies showed dopamine, one of the most commonly used rescue drugs for critically ill patients, had clear effects on the growth of K. quasivariicola in culture medium, however, its effects on host immune system were ignored. Therefore, in consideration of the host immunity, the interactions of K. quasivariicola, dopamine and macrophages were explored. In this study, RAW264.7 cells and C57/BL6 mice were infected with K. quasivariicola, and the bacterial growth in macrophage, the production of inflammatory cytokines and the pathological changes of mice lung were detected, in the absence or presence of dopamine. Our results showed dopamine inhibited the K. quasivariicola growth in medium, but promoted the bacterial growth when K. quasivariicola was co-cultured with macrophages; The expression of proinflammatory cytokines in K. quasivariicola infected RAW 264.7 were increased, while a sharp rise was observed with the addition of dopamine; Infection of K. quasivariicola to mice induced an inflammatory response and lung injury, which were exacerbated by dopamine administration. It can be concluded that dopamine administration resulted in a significantly increase of K. quasivariicola burdens in the presence of macrophage, consequently, aggravated the inflammatory response and inflammatory injury.

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Extremfrühgeborene: Begünstigt Dopamin Infektionen?

2021

Neonatologie Scan

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Association between amount of dopamine and infections in extremely preterm infants

Cited by 4 publications

References 18 publications

Dopaminergic inhibition of human neutrophils is exerted through D1‐like receptors and affected by bacterial infection

Dopaminergic inhibition of human neutrophils is exerted through D1‐like receptors and affected by bacterial infection

Dopamine promotesKlebsiella quasivariicolaproliferation and inflammatory response in the presence of macrophages

Extremfrühgeborene: Begünstigt Dopamin Infektionen?

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