Association between &amp;lt;i&amp;gt;IGF1/Tas&amp;lt;/i&amp;gt;I polymorphism and milk traits of Polish Holstein Friesian cows

Szewczuk, M.; Zych, Sławomir; Czerniawska-Piątkowska, Ewa

doi:10.5194/aab-54-10-2011

Cited by 13 publications

(19 citation statements)

References 29 publications

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“…In the analyzed herd of Polish Holstein-Friesian cattle, the highest frequency for the IGF1/TasI polymorphism was found for the AA genotype (0.6898). The studies by Zych et al (2007) and Szewczuk et al (2011) confirm a higher frequency of the A allele in the same breed of cows.…”

Section: Igf1/tasi Polymorphismmentioning

confidence: 56%

“…Similar results were obtained in other studies (Bonakdar et al, 2010;Mehmannavaz et al, 2010). Polasik et al (2010) and Szewczuk et al (2012) did not show any statistically significant association between the IGF1/SnaBI polymorphism and the milk performance traits in the Polish HolsteinFriesian cows.…”

Section: Igf1/snabi Polymorphismmentioning

confidence: 87%

“…In other population, Szewczuk et al (2011) showed that Polish Holstein-Friesian cows with the CC genotype of the IGF1/TasI polymorphism in the 2 nd and 3 rd lactation were characterized by the higher milk productivity (+ 515 kg and + 463 kg, respectively) than individuals with the AA genotype (P ≤ 0.05). Similar trends were observed for the milk protein and fat content.…”

Section: Igf1/tasi Polymorphismmentioning

confidence: 98%

“…Due to the low abundance of potentially the most wanted combination (CC/AC), this could not be confirmed statistically. In contrast, in the study performed by Szewczuk et al (2012), where combination of the IGF1/SnaBI polymorphism and SNP within gene coding its receptor -IGF1R was utilized, the IGF1R BB /IGF1…”

Section: Combined Genotypesmentioning

confidence: 99%

“…In addition, Whole Genome Shotgun (WGS) libraries contain about 100 SNPs and their number still increases. Many researchers have shown an association between the IGF1 genotypes and milk yield and composition (Curi et al, 2005;Siadkowska et al, 2006;Bonakdar et al, 2010;Mehmannavaz et al, 2010;Szewczuk et al, 2011) as well as growth traits in various cattle breeds (Li et al, 2004;Siadkowska et al, 2006;Reyna et al, 2010). The studies conducted so far have mainly been focused on the milk performance in Holstein-Friesian cattle, whereas there is no information on the association between the IGF1 gene polymorphism and the growth and development of calves and their subsequent yield as adult individuals.…”

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confidence: 99%

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Association of insulin-like growth factor I gene polymorphisms (IGF1/TasI and IGF1/SnaBI) with the growth and subsequent milk yield of Polish Holstein-Friesian heifers

Szewczuk¹,

Bajurna²,

Zych³

et al. 2013

CZECH J ANIM SCI

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ABSTRACT:The aim of this study was to estimate potential relationships between insulin-like growth factor I gene polymorphisms (IGF1/TasI and IGF1/SnaBI) and the growth parameters of calves as well as their subsequent milk performance. The study involved a total of 191 Polish Holstein-Friesian var. Black-and-White calves. Both polymorphic sites were determined with Amplification Created Restriction Sites-Polymerase Chain Reaction (ACRS-PCR). In the case of the IGF1/SnaBI polymorphism, the genotype and allele frequencies were as follows: TT -0.27, CT -0.55, CC -0.18, T -0.54, and C -0.46. The CC genotype was favourable and associated with higher body weight at the 2 nd month of age of calves (WT60) and their daily body weight gains from the 1 st to the 2 nd month (P ≤ 0.05) as well as subsequent milk, fat, and protein yield (P ≤ 0.01). For the IGF1/TasI polymorphism, the highest frequency of the AA genotype (0.69) was found. Allele frequencies were 0.75 and 0.25 for the A and C alleles, respectively. In the association study, the AC genotype was significantly associated with higher WT60 and average daily gains in the periods from the 2 nd to the 3 rd month of age and for the whole rearing period (P ≤ 0.05) as well as subsequent milk, fat, and protein yield (P ≤ 0.01). Combined genotypes were also included into the analysis. The highest yields of milk as well as fat and protein were found in cows with the CC/AA combination. No clear relationships between body weight and genotype combination were found.

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Section: Igf1/tasi Polymorphismmentioning

confidence: 56%

Section: Igf1/snabi Polymorphismmentioning

confidence: 87%

Section: Igf1/tasi Polymorphismmentioning

confidence: 98%

Section: Combined Genotypesmentioning

confidence: 99%

mentioning

confidence: 99%

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Association of insulin-like growth factor I gene polymorphisms (IGF1/TasI and IGF1/SnaBI) with the growth and subsequent milk yield of Polish Holstein-Friesian heifers

Szewczuk¹,

Bajurna²,

Zych³

et al. 2013

CZECH J ANIM SCI

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Using RNA sequencing to identify putative competing endogenous RNAs (ceRNAs) potentially regulating fat metabolism in bovine liver

Liang

Han

et al. 2017

Sci Rep

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RNA sequencing has been extensively used to study specific gene expression patterns to discover potential key genes related to complex traits of interest in animals. Of note, a new regulatory mechanism builds a large-scale regulatory network among transcriptome, where lncRNAs act as competing endogenous RNAs (ceRNAs) to sponge miRNAs to regulate the expression of miRNA target genes post-transcriptionally. In this study, we sequenced the cDNA and sRNA libraries of nine liver samples from three Holstein cows during dry period, early lactation, and peak of lactation with HiSeq platform. As a result, we identified 665 genes, 57 miRNAs and 33 lncRNAs that displayed differential expression patterns across periods. Subsequently, a total of 41ceRNA pairs (lncRNA-mRNA) sharing 11 miRNAs were constructed including 30 differentially expressed genes. Importantly, 12 among them were presented in our large metabolic networks, and predicted to influence the lipid metabolism through insulin, PI3K-Akt, MAPK, AMPK, mTOR, and PPAR signaling pathways, thus, these genes were considered as the most promising candidates for milk fat formation. To our knowledge, this is first investigation to profile the ceRNA regulatory networks of liver transcriptome that could affect milk fat synthesis in bovine, providing a new view of the regulatory mechanism of RNAs.

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Polymorphism in exon 2 encoding the putative ligand binding pocket of the bovine insulin‐like growth factor 1 receptor affects milk traits in four different cattle breeds

Szewczuk

2016

J Animal Breeding Genetics

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As a member of the somatotropic axis, insulin-like growth factor I receptor (IGF1R) seems to be a promising candidate gene. Two silent polymorphisms, identified by MspI and TaqI restriction enzymes, were selected within exon 2, encoding the majority of the putative ligand binding pocket. A total of 1169 cows of four pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. Three combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among all breeds under study, as opposed to individuals carrying the worst CC/AA combination. In view of the specific structure of the ligand binding pocket and the significance of insulin-like growth factor I signalling promoting the development and differentiation in a variety of tissues (not only limited to mammary gland), the existence of missense mutation is unlikely. Potential mutations are likely limited to mRNA transcription and further post-transcriptional modifications. Further investigations should follow searching for the most useful IGF1R haplotypes, associated with higher milk production traits, exerting at the same time positive or neutral impact on health and welfare of individuals.

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Association between <i>IGF1/Tas</i>I polymorphism and milk traits of Polish Holstein Friesian cows

Cited by 13 publications

References 29 publications

Association of insulin-like growth factor I gene polymorphisms (IGF1/TasI and IGF1/SnaBI) with the growth and subsequent milk yield of Polish Holstein-Friesian heifers

Association of insulin-like growth factor I gene polymorphisms (IGF1/TasI and IGF1/SnaBI) with the growth and subsequent milk yield of Polish Holstein-Friesian heifers

Using RNA sequencing to identify putative competing endogenous RNAs (ceRNAs) potentially regulating fat metabolism in bovine liver

Polymorphism in exon 2 encoding the putative ligand binding pocket of the bovine insulin‐like growth factor 1 receptor affects milk traits in four different cattle breeds

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