Association between amphetamine‐related disorders and dementia‐a nationwide cohort study in Taiwan

Abstract

Objective We have conducted a study to clarify the association between amphetamine‐related disorders (ARD) and the risk of developing dementia. Methods This study used a retrospective cohort design by using Taiwan’s National Health Research Institute Database. A random sample of 68,300 subjects between January 1, 2000, and December 31, 2015, was obtained, comprising of 17,075 patients with ARD, and 51,225 controls without ARD (1:3), matched for gender and age group. After adjusting for covariates, a Fine and Gray’s survival analysis (competing with mortality) was used to compare the risk of dementia during a 15‐year follow‐up period. Results In the present study, 1,751 of 17,075 patients with ARD and 2,147 of 51,225 in the control group without ARD (883.10 vs 342.83 per 100,000 person‐years) developed dementia. ARD cohort was more likely to develop dementia (hazard ratio = 4.936 [95% CI: 4.609–5.285, P < 0.001). After adjusting for gender, age groups, education, monthly insured premiums, urbanization level, geographic region, comorbidities, the hazard ratio for ARD patients was 5.034 (95% CI: 4.701–5.391, P < 0.001). ARD has been associated with overall dementia, Alzheimer dementia, vascular dementia, and other dementia. Both the amphetamine use disorder and amphetamine‐induced psychotic disorders were associated with the risk of overall dementia, Alzheimer dementia, vascular dementia, and other dementia. Interpretation This study shows that patients with ARD, both the amphetamine use disorder and the amphetamine‐induced psychotic disorder, may have a nearly fivefold risk of developing dementia, including Alzheimer dementia and other types of dementia.

Correlation between loneliness, personality traits, and treatment outcomes in patients with methamphetamine use disorder

“…Those who abused methamphetamine-type stimulants commonly started in their late teenage years or their early twenties. Any application of methamphetamines increases the risk of cardiovascular injury 2 , neurological damage 3 , psychosis, violence, suicidality, depression, and dementia 4 , 5 . Those who had methamphetamine abuse were more likely to have domestic violence toward their intimate partners 6 , intentional self-inflicted injury or internal assaults 7 , and increased annual hospital costs 8 .…”

Association Between Antibiotic Treatment of Leptospirosis Infections and Reduced Risk of Dementia: A Nationwide, Cohort Study in Taiwan

“…The National Health Insurance (NHI) Program was launched in Taiwan in 1995, and as of June 2009, includes contracts with 97% of medical providers, up to 23 million beneficiaries, and covers more than 99% of the entire population ( Ho Chan, 2010 ). Several previous studies have documented the details of this program ( Chen et al, 2020 ; Tzeng et al, 2020 ; Wan et al, 2020 ). We used the Taiwan NHI Research Database (NHIRD) to investigate the association between leptospirosis diagnosis and dementia over a 16-year period (2000–2015) for all outpatients and hospitalizations recorded in the NHIRD.…”

Toxicologia: uma abordagem multidisciplinar – Volume I

“…Ademais, a literatura mais recente apresenta que o uso de metanfetamina eleva em cinco vezes a chance de demência, incluindo a demência de Alzheimer (TZENG et al, 2020). A METH aumenta a expressão de High Mobility Group Box 1 (HMGB1), que acarreta ruptura da barreira hematoencefálica, dano neuronal, formação de placas beta-amiloide e um acréscimo geral na expressão de proteína precursora amiloide contribuindo, assim, com o desenvolvimento da doença de Alzheimer (ALABED et al, 2021).…”