Association between an angiotensin-converting enzyme gene polymorphism and Alzheimer’s disease in a Tunisian population

Fekih-Mrissa, Najiba; Bedoui, Ines; Sayeh, Aicha; Derbali, Hajer; Mrad, Meriem; Mrissa, Ridha; Nsiri, Brahim

doi:10.1186/s12991-017-0164-0

Cited by 10 publications

(8 citation statements)

References 59 publications

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“…A study in southeast Turkey indicated that women with DD or ID genotypes had a 72% increased risk of idiopathic recurrent pregnancy loss [12], while another study in northern Iran found the DD genotype to be more prevalent among women who have experienced recurrent pregnancy loss [13]. Additionally, the I/D polymorphism has been found to be associated with Alzheimer's disease; however, both the I allele [14,15] and the D allele [16] have been found to be associated with an increased risk of developing the disease. Other studies have found the I/D polymorphism to be associated with various cancers.…”

Section: Introductionmentioning

confidence: 99%

Association of Angiotensin I Converting Enzyme Insertion/287 bp Deletion Polymorphisms and Proliferative Prostatic Diseases among Lebanese Men

et al. 2020

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Background. Angiotensin I converting enzyme (ACE) insertion (I) and 287 bp Alu repeat DNA fragment deletion (D) polymorphisms have been indicated in various cancers. Here, we investigated I/D polymorphisms in prostate cancer (PCa) and benign prostate hyperplasia (BPH) among Lebanese men. Methods. Blood DNA extracted from 69 control subjects, 69 subjects with clinically confirmed PCa, and 69 subjects with clinical BPH, all the subjects were aged 50 years or older, was subjected to the polymerase chain reaction. The PCR products were resolved in polyacrylamide gels to determine II, ID, and DD genotypes. The odds ratios (OR), 95% confidence intervals (CI), and p values of the allele frequencies and genotype ratios were calculated for establishing possible association of the alleles and/or genotypes and PCa and/or BPH. Results. The proportions of II, ID, and DD genotypes were significantly different from Hardy–Weinberg equilibrium for BPH and PCa groups (but not the control group), mostly due to overabundance of the ID genotypes. There was no significant difference in the I and D allele frequencies between the control groups and the affected groups. The ratio of (DD + ID)/II is significantly lower among the control group compared to the BPH group (RR = 8.92, p=0.042), and the ratio of ID/(DD + II) is significantly lower among the control group compared to the affected groups (RR = 1.99, p=0.021). Conclusions. Our data indicate that the D allele of the I/D polymorphisms of the ACE gene is associated with increased risk of BPH, and the ID genotype is a risk factor for both BPH and PCa among Lebanese males.

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Section: Introductionmentioning

confidence: 99%

Association of Angiotensin I Converting Enzyme Insertion/287 bp Deletion Polymorphisms and Proliferative Prostatic Diseases among Lebanese Men

et al. 2020

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“…-Higher cortisol levels can enhance tau hyperphosphorylation, apoptosis, synaptic loss and mitochondrial dysfunction [70]. Delayed autoimmune response -SARS-CoV-2 may remain latent in neurons [11] meningoencephalitis, viral RNA was not detectable, which may be suggestive of transient or undetectable amounts of viral RNA in CNS [90,91].…”

Section: Cytokine Storm: Neuroimmune Mechanismsmentioning

confidence: 99%

“…This indicates that ACE-2 downregulation, induced by SARS-CoV-2 infection, might be associated with concomitant alterations in dopamine synthetic pathway, which is implicated in pathophysiology of PD [122]. Furthermore, ACE-2 gene polymorphisms have been shown to influence susceptibility to infection with COVID-19 and its complications such as multi-organ failure, although the exact association has not been determined [123,124], while specific ACE-2 polymorphisms can potentially increase the risk for PD [125] and AD [70].…”

Section: Angiotensin-converting Enzymes: Neuroprotective and Neurotoxmentioning

confidence: 99%

Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration

2021

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“…The D allele was also more frequently found in patients compared with controls (71.67 vs. 56.25%; p = 0.003, OR = 2.0). Moreover, as assessed by Mini-Mental State Examination, patients suffering from severe dementia were found predominantly in the D/D carriers group and, conversely, the D/D genotype and D allele were more frequently found in AD patients with severe dementia ( 130 ).…”

Section: Ace2 Neurological Functioning and Disease: Clinical Evidencmentioning

confidence: 96%

How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis

Panariello¹,

Cellini

Speciani

et al. 2020

Front. Psychiatry

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Interstitial pneumonia was the first manifestation to be recognized as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, in just a few weeks, it became clear that the coronavirus disease-2019 (COVID-19) overrun tissues and more body organs than just the lungs, so much so that it could be considered a systemic pathology. Several studies reported the involvement of the conjunctiva, the gut, the heart and its pace, and vascular injuries such as thromboembolic complications and Kawasaki disease in children and toddlers were also described. More recently, it was reported that in a sample of 214 SARS-CoV-2 positive patients, 36.4% complained of neurological symptoms ranging from non-specific manifestations (dizziness, headache, and seizures), to more specific symptoms such hyposmia or hypogeusia, and stroke. Older individuals, especially males with comorbidities, appear to be at the highest risk of developing such severe complications related to the Central Nervous System (CNS) involvement. Neuropsychiatric manifestations in COVID-19 appear to develop in patients with and without pre-existing neurological disorders. Growing evidence suggests that SARS-CoV-2 binds to the human Angiotensin-Converting Enzyme 2 (ACE2) for the attachment and entrance inside host cells. By describing ACE2 and the whole Renin Angiotensin Aldosterone System (RAAS) we may better understand whether specific cell types may be affected by SARS-CoV-2 and whether their functioning can be disrupted in case of an infection. Since clear evidences of neurological interest have already been shown, by clarifying the topographical distribution and density of ACE2, we will be able to speculate how SARS-CoV-2 may affect the CNS and what is the pathogenetic mechanism by which it contributes to the specific clinical manifestations of the disease. Based on such evidences, we finally hypothesize the process of SARS-CoV-2 invasion of the CNS and provide a possible explanation for the onset or the exacerbation of some common neuropsychiatric disorders in the elderly including cognitive impairment and Alzheimer disease.

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Association between an angiotensin-converting enzyme gene polymorphism and Alzheimer’s disease in a Tunisian population

Cited by 10 publications

References 59 publications

Association of Angiotensin I Converting Enzyme Insertion/287 bp Deletion Polymorphisms and Proliferative Prostatic Diseases among Lebanese Men

Association of Angiotensin I Converting Enzyme Insertion/287 bp Deletion Polymorphisms and Proliferative Prostatic Diseases among Lebanese Men

Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration

How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis

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