Association between anemia and depression: results from NHANES 2005–2018 and mendelian randomization analyses

Wang, Yashan; Guo, Dingjie; Sui, Chuanying; Qu, Zhaowei; He, Guangliang; Meng, Hengyu; Duan, Yuqing; Zhang, Xin; Lan, Lei; Wang, Chunpeng; Liu, Xin

doi:10.1007/s00277-023-05374-4

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…These results suggest that patients with mental disorders may have some degree of anemia and iron de ciency prior to their diagnosis. This is consistent with previous research that has linked iron de ciency or anemia with an increased risk of developing mental disorders [39][40][41][42] . We found positive correlations between RBC, Hb, Hct, and the ICVF values of ML, MCP, and corticospinal tract.…”

Section: Discussionsupporting

confidence: 92%

Temporal trends of blood-based markers in various mental disorders and their relationship with brain structure

Cheng,

Yujia,

Jia

et al. 2024

Preprint

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Background: Studies have identified blood-based biomarkers for various mental disorders, but their temporal trends and relationship with brain structure remain unclear. This study aimed to assess the temporal trends of blood-based biomarkers across 10 years leading up to and following diagnosis and explore their association with brain structure. Methods: We conducted a nested case-control study using prospective community-based cohort data from UK Biobank (n = 502,617; aged 40 to 69 years; recruited from 2006 to 2010), which included both psychiatric assessments and blood-based biomarkers. Cases were defined as individuals with a diagnosis of mental disorders at baseline and during follow-up (individuals with bipolar disorder = 1,325; depression = 36,582; schizophrenia = 1,479; anxiety = 27,220). Nearly 5 controls without any mental disorders were matched for each case. Multivariable linear regression was used to assess the divergence evolution between cases and controls for each psychiatric assessment and blood-based biomarker. Results: In comparison to controls, 6, 15, 10, and 47 blood-based markers exhibited significant changes over time in bipolar disorder, anxiety, schizophrenia, and depression, respectively. These biomarkers could be grouped into distinct clusters with complex, non-linear temporal trends. Some clusters displayed monotonic changes, while others reversed near the time of diagnosis. The identified blood-based markers were associated with brain structure in the general population, including orbitofrontal, precuneus, and amygdala regions. Conclusions: These findings provide novel insights into the temporal trends of blood-based biomarkers in various mental disorders within 10 years before and after clinical diagnosis, as well as their correlations with brain structure. Monitoring and managing these biomarkers could potentially carry significant implications for the early detection and prevention of mental disorders in older adults.

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Section: Discussionsupporting

confidence: 92%

Temporal trends of blood-based markers in various mental disorders and their relationship with brain structure

Cheng,

Yujia,

Jia

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The current research on the correlation between anemia and depression has yielded inconsistent results, leading to discussions and analyses among researchers. We are interested in reading the study conducted by Wang et al, which was published in advance on July 22, 2023, in the Annals of Hematology [ 1 ]. This cross-sectional study aimed to evaluate the relationship between anemia/hemoglobin levels and depression among 29,391 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2018.…”

mentioning

confidence: 99%

“…Research has also indicated a negative correlation between hemoglobin and depression among female students at Tehran University of Medical Sciences in Iran [ 5 ], suggesting that controlling for certain confounding factors can amplify this association. Although the previous study [ 1 ] concluded a lack of significant causal relationship, existing evidence still leans towards a direct correlation between hemoglobin and depression [ 3 , 6 , 7 ]. Therefore, it is crucial to pay attention to the psychological status of anemic patients in clinical practice.…”

mentioning

confidence: 99%

Comment on: Association between anemia and depression: results from NHANES 2005–2018 and Mendelian randomization analyses

Si,

Ma,

Zhu

et al. 2023

Ann Hematol

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Longitudinal trajectories of immunometabolic marker in various mental disorders and their relationship with brain structures

Cheng,

Yujia,

You

et al. 2024

Preprint

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Background: Studies have identified immunometabolic biomarkers for various mental disorders, but their temporal evolution and relationship with brain structure remain unclear. This study aimed to assess the long-term trajectories of immunometabolic biomarkers across 10 years leading up to and following diagnosis and explore their association with brain structure. Methods: We conducted a nested case-control study using prospective community-based cohort data from UK Biobank, which included both psychiatric assessments and immunometabolic markers. Cases were defined as individuals with a diagnosis of mental disorders at baseline and during follow-up. Nearly 5 controls without any mental disorders were matched for each case. Multivariable linear regression was used to assess the divergence evolution between cases and controls for each psychiatric assessment and immunometabolic biomarker. Results: In comparison to controls, 6, 15, 10, and 47 immunometabolic markers exhibited significant changes over time in bipolar disorder, anxiety, schizophrenia, and depression, respectively. These biomarkers could be grouped into distinct clusters with complex, non-linear trajectories. Some clusters displayed monotonic changes, while others reversed near the time of diagnosis. The identified immunometabolic markers were associated with brain structure in the general population, including orbitofrontal, precuneus, and amygdala regions. Conclusions: These findings provide novel insights into the temporal dynamics of immunometabolic biomarkers in various mental disorders within 10 years before and after clinical diagnosis, as well as their correlation with brain structure. Monitoring and managing these biomarkers could potentially carry significant implications for the early detection and prevention of mental disorders in older adults.

show abstract

Association between anemia and depression: results from NHANES 2005–2018 and mendelian randomization analyses

Cited by 5 publications

References 30 publications

Temporal trends of blood-based markers in various mental disorders and their relationship with brain structure

Temporal trends of blood-based markers in various mental disorders and their relationship with brain structure

Comment on: Association between anemia and depression: results from NHANES 2005–2018 and Mendelian randomization analyses

Longitudinal trajectories of immunometabolic marker in various mental disorders and their relationship with brain structures

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