Association between Anemia and New-Onset Atrial Fibrillation in Critically Ill Patients in the Intensive Care Unit: A Retrospective Cohort Analysis

Abstract

New-onset atrial fibrillation (NOAF) is one of the leading causes of morbidity and mortality, especially in older patients in the intensive care unit (ICU). Although many comorbidities are associated with NOAF, the effect of anemia on the onset of atrial fibrillation is still unknown. This study aimed to test the hypothesis that anemia is associated with an increased risk of developing NOAF in critically ill patients in intensive care. We performed a retrospective analysis of critically ill patients who underwent routine hemoglobin and electrocardiography monitoring in the ICU. Receiver operating characteristics analysis determined the hemoglobin (Hb) value that triggered NOAF formation. Bivariate correlation was used to determine the relationship between anemia and NOAF. The incidence of NOAF was 9.9% in the total population, and 12.8% in the patient group with anemia. Analysis of 1931 patients revealed a negative association between anemia and the development of NOAF in the ICU. The stimulatory Hb cut-off value for the formation of NOAF was determined as 9.64 g/dL. Anemia is associated with the development of NOAF in critically ill patients in intensive care.

In Hospital Prognosis in Patients Treated with Primary Percutaneous Coronary Intervention, Role of Admission Hemoglobin Level

“…The mentioned study determined a stimulatory cut-off value for the incidence of NOAF with Hb level of 9.96 g/dL. [8] Another large perspective cohort study from Japan followed up a cohort of 132,250 Japanese patients for a mean period of 13.8 years. They reached a conclusion that anemia is associated with higher incidence of AF.…”

The Influence of Anemia on Mortality Rates, Duration of Hospitalization, and Resource Utilization in Patients Admitted With a Primary Diagnosis of Ventricular Tachycardia: A Nationwide Analysis 2016-2020

“…Anemia has a high prevalence in the US 12 and it is associated with poor outcomes in heart diseases due to its hyperdynamic state [13][14][15][16] . Although there are data on the relation between anemia and heart failure and atrial fibrillation [7][8][9] , its relation to ventricular tachycardia lack evidence. In this study, authors used the national inpatient sample from 2016 to 2020 to analyze the difference in outcomes in patients with a primary diagnosis of ventricular tachycardia and anemia compared with the general population.…”

“…As such, the imperative nature of discerning the risks correlated with this pathological condition is clear. Anemia has been demonstrated to affect outcomes of atrial fibrillation 7,8,9 and studies showed its association with supraventricular tachycardia 10 . Anemia is also known to increase cardiovascular morbidity and mortality 11 .…”

Iron deficiency, anemia and atrial fibrillation

“…При этом было определено пороговое значение уровня гемоглобина для развития впервые возникшей ФП -96,4 г/л. Таким образом, была подтверждена гипотеза о том, что наличие анемии ассоциировано с повышенным риском развития ФП у пациентов, нуждающихся в лечении в отделении интенсивной терапии [32].…”