Association between angiotensin converting enzyme polymorphism and lead-related hypertensive status in lead-exposed male workers from Korea

Kim, Hak Jae; Joo, Jaesoon; Lee, Soojeong; Nah, Seong Su; Jeong, Dong Jun; Lee, Sang‐Han; Kim, Nam Soo; Lee, Byung Kook

doi:10.1007/s13273-012-0043-3

Cited by 2 publications

(3 citation statements)

References 47 publications

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“…Previously, we investigated the association between the ACE gene, an important gene in the renin-angiotensin system and lead-related hypertension. 29 In that report, we executed a cross sectional study involving 786 male lead-exposed workers from Korea, in which a PCR-based strategy was used to differentiate the genotypes of ACE I/D polymorphism. The distribution of genotypes among 786 male lead-exposed workers was in HWE and was similar to that in a previous study in Korean subjects (genotype distribution: II 36.5%, ID 48.7%, DD 14.9%).…”

Section: Discussionmentioning

confidence: 99%

“…28 In addition, we showed previously that the II genotype I allele in ACE is associated with a higher risk of leadrelated hypertensive status. 29 No evidence of an association of lead-related hypertension with AGTR1 A1166C and AGT M235T polymorphisms has been presented. Thus, we investigated associations between genetic polymorphisms in the AGTR1 A1166C and AGT M235T and blood lead levels and lead-related blood pressure in lead-exposed workers in Korea.…”

Section: Introductionmentioning

confidence: 99%

“…28 In addition, we showed previously that the II genotype I allele in ACE is associated with a higher risk of lead-related hypertensive status. 29…”

Section: Introductionmentioning

confidence: 99%

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A polymorphism inAGTandAGTR1gene is associated with lead-related high blood pressure

Kim

Lee

Kwon

et al. 2014

J Renin Angiotensin Aldosterone Syst

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We investigated the association of polymorphisms in two renin-angiotensin system-related genes, expressed as angiotensinogen (AGT) and angiotensin II type 1 receptor (AGTR1), with blood lead levels and lead-related blood pressure in lead-exposed male workers in Korea. A cross-sectional study involving 808 lead-exposed male workers in Korea was conducted using a restriction fragment length polymorphism-based strategy to differentiate the various genotypes of polymorphisms in the AGT and AGTR1 genes. The association of clinical characteristics with genotypes as modifiers was estimated after adjustment for age, smoking status, drinking status, body mass index and job duration of each subject. Genotype and allele frequencies of the M235T polymorphism in AGT were associated with lead-related high blood pressure status. Moreover, blood lead levels were associated with allele frequencies of the AGT M235T polymorphism. These results suggested that the M/M genotype and M allele of AGT are risk factors for lead-related high blood pressure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%