Association between angiotensin-converting enzyme insertion/deletion polymorphism and migraine: a meta-analysis

Wan, Dongjun; Wang, Chunyu; Zhang, Xiaofei; Tang, Wenjing; Chen, Min; Zhao, Dong; Yu, Shengyuan

doi:10.3109/00207454.2015.1025395

Cited by 10 publications

(3 citation statements)

References 34 publications

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“…At molecular level, an immunocytochemical investigation has uncovered the presence of an angiotensinergic system in the trigeminal ganglia of humans and rats 5 , suggesting a role for this signaling system in migraine pathophysiology. At genetic level, a meta-analysis found no association between ACE I/D polymorphism and migraine, albeit in the Turkish population ACE II polymorphism -which is characterized by lower ACE expression than DD polymorphism -was associated with reduced risk for migraine 4 . Furthermore, ACE inhibitors or AngII receptor antagonists are common prophylactic drugs prescribed for migraine 15,16 .…”

Section: Discussionmentioning

confidence: 93%

“…Angiotensin-I-converting enzyme (ACE), a key protease of the renin angiotensin system (RAS), has been implicated in migraine pathophysiology by mechanisms still not understood [3][4][5] . ACE cleavages angiotensin-I into angiotensin-II (AngII), a potent vasoconstrictor which also orchestrates several physiological adjustments and adaptations in response to acute and chronic physical exercise 6,7 .…”

Section: Introductionmentioning

confidence: 99%

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Plasma ACE activity after aerobic exercise training is related to sleep in migraine patients: A secondary, per protocol analysis

Oliveira

Visniauskas

Chagas

et al. 2020

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Angiotensin converting enzyme-1 (ACE) has been implicated in sleep regulation and nociception. In a secondary, per-protocol analysis, we investigated the effect of a 12-week aerobic exercise program on plasma ACE activity (primary outcome variable), migraine clinical outcomes, and psychometric scores between migraine and control, non-headache participants. Fifty-nine participants (migraine: n=31 and control: n=28) gave signed consent form and were per-protocol analyzed. At baseline, there were no differences between groups for ACE activity. After the intervention period, the ACE activity increased in the migraine exercise group compared to control waitlist group [mean difference (95% CI) = 33.8 nM.min– 1.mg–1 (1.0, 66.5), p = 0.02]. Among patients, the migraine exercise group showed greater numeric reduction in the number of sleep deprivation-triggered attacks compared to migraine waitlist group (-21 vs -8, respectively), and lower insomnia scores [mean difference (95% CI) = -0.625 (-996, -254), p = 0.001]. There was an inverse correlation between BECK-II insomnia domain scores and ACE activity (r = -0.53, p = 0.035). This study suggests that aerobic exercise training increases plasma ACE activity with possible implication on sleep regulation in migraine patients.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Plasma ACE activity after aerobic exercise training is related to sleep in migraine patients: A secondary, per protocol analysis

Oliveira

Visniauskas

Chagas

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Interestingly all studies 13 , 17 , 24 were from north India, thus disparity between such might be due to different sample sizes i.e., control and case subjects. Evidence from the meta-analysis published in 2016 powered with 7334 patients and 22,990 control showed no relationship between the ACE I/D polymorphism and any migraine but upon subgrouping based on the criteria of ethnicity, they observed a protective effect against migraine with aura and without aura at least in the Turkish population 41 .…”

Section: Discussionmentioning

confidence: 97%

Comprehensive analysis of genes associated with migraine in the Indian population: a meta-analysis of genetic association studies with trial sequential analysis

Sudershan,

Pushap,

Bhagat

et al. 2023

Sci Rep

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Migraine is a complex disorder with multigenic inheritance and is characterized by the cardinal symptom of unilateral headache. Many genes are responsible for increasing the susceptibility of disease within different populations. Therefore, our primary aim in this review was to catalog the many genes that have been studied in India and after collecting the necessary information, we calculated a more precise risk relationship between an identified variation and migraine. The gene and its associated risk variant were discovered in the Indian population using a PRISMA-based systematic literature review guideline from online databases such as PubMed & Google Scholar. We constructed pooled odds ratios with 95% confidence intervals using multiple genetic models. Also, we looked for heterogeneity using Cochran's Q Test and the I2 statistic. Publication bias was analyzed using Begg's and Egger's tests. A p-value less than 0.05 was judged to be statistically significant for all tests. After a critical analysis, a total of 24 studies explored about 21 genes with 31 variants out of which only nine genes have been studied more than two times in the Indian population and thus were found eligible for the meta-analysis. It has been found, that the ACE-DD variant (allele model: OR: 1.37 [1.11–1.69], I2 = 0%/ fixed model), ESR1-PvuII (allele model: OR: 1.47 [1.24–1.74], I2 = 0%/ fixed model) significantly increases the risk of migraine in Indian population. Also, a protective role of the LRP1-rs11172113variant was observed for both migraine and its clinical subtype i.e., MA (allelic model: OR of 0.65 [0.50–0.83] I2 = 44% and allele: OR: 0.54 [0.37–0.78], I2 = 52%) respectively. Overall, the results of this meta-analysis indicated that the ACE-DD variant and the ESR1-PvuII were associated with an increased risk of migraine in the Indian community, while the LRP1-rs11172113 variant was associated with protection from migraine in this population.

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A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression

Sudershan,

Pushap,

Kumar

et al. 2023

J Mol Neurosci

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Association between angiotensin-converting enzyme insertion/deletion polymorphism and migraine: a meta-analysis

Abstract: The data suggest that the ACE II genotype could exert a protective effect against migraine with aura and without aura at least in the Turkish population.

Cited by 10 publications

References 34 publications

Plasma ACE activity after aerobic exercise training is related to sleep in migraine patients: A secondary, per protocol analysis

Plasma ACE activity after aerobic exercise training is related to sleep in migraine patients: A secondary, per protocol analysis

Comprehensive analysis of genes associated with migraine in the Indian population: a meta-analysis of genetic association studies with trial sequential analysis

A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression

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