2016
DOI: 10.4238/gmr.15017194
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Association between angiotensin-converting enzyme insertion/deletion polymorphisms and the risk of heart disease: an updated meta-analysis

Abstract: ABSTRACT. Insertion/deletion (I/D) polymorphisms of the gene encoding angiotensin converting enzyme (ACE) are a controversial risk factor for heart diseases (HDs). ACE I/D polymorphism has been reported to be associated with various cardiovascular diseases. However, some studies have presented conflicting results. In this study, we aim to explore the association between ACE I/D polymorphisms and the risk of coronary HD (CHD), coronary artery disease (CAD), and myocardial infarction (MI). A meta-analysis was co… Show more

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Cited by 13 publications
(14 citation statements)
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“…The relationship between the ACE gene and the genesis of CAD is controversial [24][25][26][27][28][29]. It and Shen demonstrated, in a meta-analysis of 118 studies, a positive association between the DD and ID genotypes and CAD, identifying the significant heterogeneity of these results [30]. Such incongruities in scientific research are related to studies that treat different populations that have their own characteristics as a single population.…”
Section: Discussionmentioning
confidence: 96%
“…The relationship between the ACE gene and the genesis of CAD is controversial [24][25][26][27][28][29]. It and Shen demonstrated, in a meta-analysis of 118 studies, a positive association between the DD and ID genotypes and CAD, identifying the significant heterogeneity of these results [30]. Such incongruities in scientific research are related to studies that treat different populations that have their own characteristics as a single population.…”
Section: Discussionmentioning
confidence: 96%
“…In the present study, peripheral BP and central BP values were not significantly different among the AT1R +1166A/C single nucleotide polymorphism. The differences in allele frequency among different ethnic groups are larger, and the same between patients with hypertension and normotension . Several studies have found that among different ethnic groups, locations, and sexes, the A1166c polymorphism may play different roles for essential hypertension .…”
Section: Discussionmentioning
confidence: 99%
“…Emerging evidence suggests that central pressure is better related to future cardiovascular events than is brachial pressure. Among genetic polymorphisms of different components of RAS, the I/D polymorphism of the ACE gene is shown to be associated with a wide range of cardiovascular complications . In spite of few studies on the relationship between RAS gene polymorphism and central BP, it has been concluded that modifying central hemodynamics seems to be a possible mode of action of ACE I/D polymorphism mediating the onset of clinical cardiovascular events.…”
Section: Discussionmentioning
confidence: 99%
“…As a matter of fact, the ACE I/D polymorphism accounts for approximately one‐half of the variance shown by ACE plasma levels. Moreover, several diseases and conditions have reported the I/D polymorphism . For instance, You et al .…”
Section: Discussionmentioning
confidence: 99%
“…For instance, You et al . showed that the D allele of ACE was significantly associated with increased risk of heart disease . Yang et al .…”
Section: Discussionmentioning
confidence: 99%