| INTRODUCTIONIt is well known that the renin-angiotensin system (RAS) plays a cen- found that the T allele of C-5312T single nucleotide polymorphism and the haplotype containing T was associated with elevated BP levels in healthy humans, and this association of renin 5312 C/T genotype with BP was independent of age and sex.3 Another longitudinal studyshowed that the C allele carrier in the A1166C polymorphism had a 35% more pronounced increase in aortic arterial stiffness over a 16-year period than the AA allele patients, and this difference in pulse wave velocity was only observed after the age of 55 years. 4 Likewise, a case control study indicated that the D allele of the ACE gene was probably associated with the development of left ventricular hypertrophy in patients with hypertension who developed heart failure.
5However, recent research conducted in India revealed that the ACE ID genotype increases the susceptibility to hypertension and is strongly