Association between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: A meta-analysis

Pan, Yu‐Qing; Lin, Qiao; Xue, Xin-dong; Fu, Jianhua

doi:10.1016/j.neulet.2015.01.076

Cited by 36 publications

(32 citation statements)

References 46 publications

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“…This finding is not surprising since this SNP explains only a small percent of the variance in BMI of the population, making larger samples, and more accurate measures of adiposity necessary to observe reliable associations. In addition to obesity the A1 allele is associated with a number of disorders in which DA signaling is affected including attention deficit hyper activity disorder (ADHD) [65], addiction [66], alcoholism [67], poorer outcomes following traumatic brain injury [68, 69] and Parkinson’s disease [70]. …”

Section: Taqia Polymorphism (Rs1800497)mentioning

confidence: 99%

DRD2: Bridging the Genome and Ingestive Behavior

Sun

Luquet

2017

Trends in Cognitive Sciences

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Recent work highlights the importance of genetic variants that influence brain structure and function in conferring risk for polygenic obesity. The neurotransmitter dopamine (DA) plays a pivotal role in energy balance by integrating metabolic signals with circuits supporting cognitive, perceptual and appetitive functions that guide feeding. It has also been established that diet and obesity alter DA signaling leading to compulsive-like feeding and neurocognitive impairments. This raises the possibility that genetic variants that influence DA signaling and adaptation confer risk for overeating and cognitive decline. We consider the role of two common gene variants, FTO and TaqIA rs1800497 in driving gene * environment interactions promoting obesity, metabolic dysfunction, and cognitive change via their influence on dopamine receptor subtype 2 signaling.

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Section: Taqia Polymorphism (Rs1800497)mentioning

confidence: 99%

DRD2: Bridging the Genome and Ingestive Behavior

Sun

Luquet

2017

Trends in Cognitive Sciences

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“…Maternal inflammation has been previously shown to cause offspring deficits in latent and prepulse inhibition, along with decreased social and exploratory behavior (Smith et al, 2007), which are associated with dopamine dysfunction and mental health disorders such as schizophrenia and ASD. The increased inflammation that accompanies maternal HFD consumption likely impacts the dopaminergic system of offspring, causing increased risk of psychopathology as changes in the dopaminergic system are associated with disorders such as ASD(Bowton et al, 2014; Hamilton et al, 2015; Staal, 2014), ADHD (Hasler et al, 2015; Pan et al, 2015; Tong et al, 2015), schizophrenia (Howes et al, 2015; Slifstein et al, 2015; Sumiyoshi et al, 2014), anxiety (Agius et al, 2014; Lee et al, 2015), and depression (Clausius et al, 2009; Dunlop and Nemeroff, 2007). …”

Section: Mechanisms By Which Maternal High-fat Diet Consumption mentioning

confidence: 99%

Maternal high-fat diet programming of the neuroendocrine system and behavior

Sullivan

Riper

Lockard

et al. 2015

Hormones and Behavior

148

108

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Maternal obesity, metabolic state, and diet during gestation have profound effects on offspring development. The prevalence of neurodevelopmental and mental health disorders has risen rapidly in the last several decades in parallel with the rise in obesity rates. Evidence from epidemiological studies indicates that maternal obesity and metabolic complications increase the risk of offspring developing behavioral disorders such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD), and schizophrenia. Animal models show that a maternal diet high in fat similarly disrupts behavioral programming of offspring, with animals showing social impairments, increased anxiety and depressive behaviors, reduced cognitive development, and hyperactivity. Maternal obesity, metabolic conditions, and high fat diet consumption increase maternal leptin, insulin, glucose, triglycerides, and inflammatory cytokines. This leads to increased risk of placental dysfunction, and altered fetal neuroendocrine development. Changes in brain development that likely contribute to the increased risk of behavioral and mental health disorders include increased inflammation in the brain, as well as alterations in the serotonergic system, dopaminergic system and hypothalamic pituitary adrenal (HPA) axis.

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“…In addition to this, we also included genes with reported and replicated evidence for association with ADHD from more recent studies. These included two meta-analytic studies (Pan et al, 2015;Wu et al, 2012), a research article (Ribases et al, 2011), and the more recently observed replicated candidate genes NOS1 and SLC9A9 (Stergiakouli et al, 2012;Weber et al, 2015) (total number of candidate genes = 10; Table 1). A recent overview of these ADHD candidate genes has been published by Hawi et al (2015).…”

Section: Candidate Gene Selection For Adhd Asd and Id Studiesmentioning

confidence: 99%

Imaging genetics in neurodevelopmental psychopathology

Klein

Donkelaar

Verhoef

et al. 2017

American J of Med Genetics Pt B

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Neurodevelopmental disorders are defined by highly heritable problems during development and brain growth. Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), and intellectual disability (ID) are frequent neurodevelopmental disorders, with common comorbidity among them. Imaging genetics studies on the role of disease-linked genetic variants on brain structure and function have been performed to unravel the etiology of these disorders. Here, we reviewed imaging genetics literature on these disorders attempting to understand the mechanisms of individual disorders and their clinical overlap. For ADHD and ASD, we selected replicated candidate genes implicated through common genetic variants. For ID, which is mainly caused by rare variants, we included genes for relatively frequent forms of ID occurring comorbid with ADHD or ASD. We reviewed case-control studies and studies of risk variants in healthy individuals. Imaging genetics studies for ADHD were retrieved for SLC6A3/DAT1, DRD2, DRD4, NOS1, and SLC6A4/5HTT. For ASD, studies on CNTNAP2, MET, OXTR, and SLC6A4/5HTT were found. For ID, we reviewed the genes FMR1, TSC1 and TSC2, NF1, and MECP2. Alterations in brain volume, activity, and connectivity were observed. Several findings were consistent across studies, implicating, for example, SLC6A4/5HTT in brain activation and functional connectivity related to emotion regulation. However, many studies had small sample sizes, and hypothesis-based, brain region-specific studies were common. Results from available studies confirm that imaging genetics can provide insight into the link between genes, disease-related behavior, and the brain. However, the field is still in its early stages, and conclusions about shared mechanisms cannot yet be drawn.

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Association between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: A meta-analysis

Cited by 36 publications

References 46 publications

DRD2: Bridging the Genome and Ingestive Behavior

DRD2: Bridging the Genome and Ingestive Behavior

Maternal high-fat diet programming of the neuroendocrine system and behavior

Imaging genetics in neurodevelopmental psychopathology

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