Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms

Xu, Hui; Wang, Zhang Yang; Chen, Jing Feng; Wang, Tian Yang; Wang, Ling Ling; Tang, Li; Lin, Xian-yang; Zhang, Chun-wu; Chen, Bicheng

doi:10.1371/journal.pone.0122055

Cited by 39 publications

(43 citation statements)

References 37 publications

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“…As for the miR - 146a SNP, some associations with pathogenesis of rheumatic diseases have been described especially for patients with ankylosing spondylitis in a Han Chinese population (Xu et al 2015). However, this SNP has not been reported to be associated with RA in either Asian or Caucasian populations (Chatzikyriakidou et al 2010; El-Shal et al 2013; Zhou et al 2015; the present study).…”

Section: Discussionmentioning

confidence: 99%

Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis

Bogunia‐Kubik

Wysoczańska

Piątek

et al. 2016

Arch. Immunol. Ther. Exp.

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MicroRNA-146a (miR-146a) has been shown to play an important role in the regulation of inflammatory innate immune responses, and found to be differentially expressed in rheumatoid arthritis (RA). Through NF-κB pathway, this molecule is able to stimulate the release of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-17. It has been also suggested that single-nucleotide polymorphisms (SNPs) in miRNA sequences may alter miRNA expression and that miR-146a rs2910164 SNP may contribute to RA development. These observations prompted us to analyze the potential associations between the miR-146a-3p (rs2910164, G > C) and NFkB1 (rs28362491, ins/del ATTG) polymorphisms and miR-146a-5p expression in patients’ sera in relation to clinical outcome of the treatment as well as predisposition to RA. Genotyping was performed in 111 patients and 130 healthy individuals while 16 controls and 13 RA patients (before and after three months of therapy with TNF-α inhibitors (TNFi)) were studied for the circulating miR-146a-5p serum expression level. Patients carrying the NFkB1 ins/ins genotype were characterized by worse response to TNFi treatment (p = 0.023). In patients, before TNFi therapy, expression levels of miR-146a-5p were less (0.422 ± 0.171) as compared to those detected after three months of treatment (1.809 ± 0.658, p = 0.033) and observed for healthy controls (5.302 ± 2.112, p = 0.048). Moreover, patients with higher circulating miR-146a-5p levels after three months of TNFi administration were more frequently carrying the rs2910164-C allele (p = 0.032). These results support the hypothesis that miR-146a might be involved in pathogenesis of RA and imply that miR-146a-3p polymorphism may be associated with miR-146a-5p levels in serum after anti-TNF-α treatment.

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Section: Discussionmentioning

confidence: 99%

Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis

Bogunia‐Kubik

Wysoczańska

Piątek

et al. 2016

Arch. Immunol. Ther. Exp.

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“…Xu et al () investigated the connection between AS and two single nucleotide polymorphisms (SNPs), miR‐146a rs2910164G>C, and miR‐499 rs3746444T>C, in a Han Chinese population. A case‐control study including of 102 subjects with AS and 105 healthy controls was designed.…”

Section: Biogenesis Of Mirnasmentioning

confidence: 99%

MicroRNA implications in the etiopathogenesis of ankylosing spondylitis

Mohammadi

Hemmatzadeh

Babaie

et al. 2018

Journal Cellular Physiology

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Ankylosing spondylitis (AS) is a chronic immune-mediated inflammatory disease that affects both axial and peripheral skeletons as well as soft tissues. Recent investigations offer that disease pathogenesis is ascribed to a complex interplay of genetic, environmental, and immunological factors. Until now, there is no appropriate method for early diagnosis of AS and the successful available therapy for AS patients stay largely undefined. MicroRNAs (miRNAs), endogenous small noncoding RNAs controlling the functions of target mRNAs and cellular processes, are present in human plasma in a stable form and have appeared as possible biomarkers for activity, pathogenesis, and prognosis of the disease. In the present review, we have tried to summarize the recent findings related to miRNAs in AS development and discuss the possible utilization of these molecules as prognostic biomarkers or important therapeutic strategies for AS. Further examinations are needed to determine the unique miRNAs signatures in AS and characterize the mechanisms mediated by miRNAs in the pathology of this disease.

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“…The two miRNA polymorphisms had no association with the AS activity level. As a conclusion, Xu et al (2015) 18 through their research found that the miR-146a rs2910164 variant was related with increased risk of AS at both the allelic and genotypic stages. The G allele and GG genotype were more prevalent in the patients than in the control group.…”

Section: Polymorphisms Of Mirnas and Their Target Genes In Asmentioning

confidence: 89%

“…According to the previous statement a quite interesting research was conducted by Xu et al (2015) 18 between March 2013 and April 2014 in a Chinese province researching the possibility of a significant correlation between SNPs -located in miR-14a and miR-499-and ankylosing spondylitis. The study was composed by two groups.…”

Section: Polymorphisms Of Mirnas and Their Target Genes In Asmentioning

confidence: 99%

The role of miRNAs in ankylosing spondylitis: a narrative review

Diakos¹,

Lambrou²

2019

JRPMS

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Ankylosing Spondylitis (AS) is a chronic, autoimmune inflammatory disease mainly affecting the axial skeleton and it might lead to functional and structural impairments and cause severe disability, thus, jeopardize quality of life. The last two decades, the potential role of miRNAs in the pathogenesis of AS has been under investigation in numerous studies. The aim of this article is to review the available literature on the involvement of miRNAs in AS pathogenesis. An electronic literature search was conducted by two independent researchers up to 2013. Titles and abstracts of papers were validated by the authors for further inclusion in the present work. At the end, full texts of the included articles were retrieved. SNPs of miRNAs lead to an overexpression of pro-inflammatory cytokines. Deregulated miRNAs enhance the production of pro-inflammatory cytokines, suppress autophagy in T peripheral cells of the blood. MiRNAs through a vast number of research have a potential correlation with AS pathogenesis. Because of their stable structure which easily could be extracted from cells of blood samples, the different expressed levels of miRNAs in peripheral blood and tissues from the joints could be used as potential biomarkers of the activity and the efficacy of the treatment in AS.

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Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms

Cited by 39 publications

References 37 publications

Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis

Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis

MicroRNA implications in the etiopathogenesis of ankylosing spondylitis

The role of miRNAs in ankylosing spondylitis: a narrative review

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