Association between antibiotic resistance and increasing ambient temperature in China: an ecological study with nationwide panel data

Li, Weibin; Liu, George; Ho, Hung Chak; Shi, Lin; Zeng, Yingchao; Yang, Xinyi; Huang, Qixian; Yi, Peng; Huang, Cunrui; Yang, Lianping

doi:10.1016/j.lanwpc.2022.100628

Cited by 27 publications

(27 citation statements)

References 47 publications

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“…Our results from the multivariable analysis also revealed positive associations between AMR and both antibiotic consumption and population density, which align with prior findings in the US and China [ 21 , 25 ]. However, it is necessary to note that McGough and colleagues reported a negative association between population density and AMR across European countries [ 24 ], indicating a need to assess the reliability of this relationship more thoroughly.…”

Section: Discussionsupporting

confidence: 91%

“…The authors found that warmer ambient temperature—assessed through the annual minimum temperature over a 17-year period (2000–2016)—was associated with a higher percentage of resistance for E. coli and K. pneumoniae [ 24 ]. There was also some research looking at the potential relationship between temperature and AMR outside of Europe, in particular in China and the US [ 21 , 25 ]. According to Li and colleagues, the prevalence of K. pneumoniae and Pseudomonas aeruginosa resistant to carbapenems increased with increasing average ambient temperature in 28 Chinese provinces over a 15-year period (2005–2019) [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…There was also some research looking at the potential relationship between temperature and AMR outside of Europe, in particular in China and the US [ 21 , 25 ]. According to Li and colleagues, the prevalence of K. pneumoniae and Pseudomonas aeruginosa resistant to carbapenems increased with increasing average ambient temperature in 28 Chinese provinces over a 15-year period (2005–2019) [ 21 ]. Across the US, MacFadden and colleagues reported an association between an increase in ambient temperature and increases in AMR of E. coli , K. pneumoniae , and S. aureus between 2013 and 2015 [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…For this reason, there has been growing interest in recent years in evaluating other factors that may contribute to the spread of AMR. Some of these factors include changes in the environment, such as temperature [ 21 , 22 , 23 , 24 , 25 ], as well as the exchange of genetic material between bacteria, which can lead to the spread of AMR genes [ 26 , 27 , 28 ]. Additionally, studies have also shown that population density, poor governance, reduced public health-care expenditure, abuse of disinfectants and biocides, and the presence of other stressors in the environment can also play a role in the development and spread of AMR [ 14 , 18 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

“…This warming trend is expected to continue, and its effects on AMR are the subject of ongoing research. Previous studies have suggested a relationship between temperature change and AMR [ 21 , 22 , 23 , 24 , 25 ]. For example, some studies have found that higher temperatures can increase the rate at which bacteria develop resistance to antibiotics [ 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

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Socioeconomic and Governance Factors Disentangle the Relationship between Temperature and Antimicrobial Resistance: A 10-Year Ecological Analysis of European Countries

et al. 2023

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Although previous studies showed that warmer temperatures may be associated with increased antimicrobial resistance (AMR) rates, unmeasured factors may explain the observed relationship. We conducted a ten-year ecological analysis to evaluate whether temperature change was associated with AMR across 30 European countries, considering predictors that can determine a geographical gradient. Using four data sources, we created a dataset of: annual temperature change (FAOSTAT database); AMR proportions for ten pathogen–antibiotic combinations (ECDC atlas); consumption of antibiotics for systemic use in the community (ESAC-Net database); population density, gross domestic product (GDP) per capita, and governance indicators (World Bank DataBank). Data were obtained for each country and year (2010–2019) and analyzed through multivariable models. We found evidence of a positive linear association between temperature change and AMR proportion across all countries, years, pathogens, and antibiotics (β = 0.140; 95%CI = 0.039; 0.241; p = 0.007), adjusting for the effect of covariates. However, when GDP per capita and the governance index were included in the multivariable model, temperature change was no longer associated with AMR. Instead, the main predictors were antibiotic consumption (β = 0.506; 95%CI = 0.366; 0.646; p < 0.001), population density (β = 0.143; 95%CI = 0.116; 0.170; p < 0.001), and the governance index (β = −1.043; 95%CI = −1.207; −0.879; p < 0.001). Ensuring the appropriate use of antibiotics and improving governance efficiency are the most effective ways of counteracting AMR. It is necessary to conduct further experimental studies and obtain more detailed data to investigate whether climate change affects AMR.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Socioeconomic and Governance Factors Disentangle the Relationship between Temperature and Antimicrobial Resistance: A 10-Year Ecological Analysis of European Countries

et al. 2023

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Effects of sulfamethoxazole and copper on the natural microbial community from a fertilized soil

Narciso,

Grenni,

Spataro

et al. 2024

Appl Microbiol Biotechnol

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Cattle manure or its digestate, which often contains antibiotic residues, can be used as an organic fertilizer and copper (Cu) as a fungicide in agriculture. Consequently, both antibiotics and Cu are considered soil contaminants. In this work, microcosms were performed with soil amended with either manure or digestate with Cu and an antibiotic (sulfamethoxazole, SMX) copresence and the planting of Lactuca sativa. After the addition of the organic amendments, a prompt increase in the microbial activity and at the same time of the sul1 and intI1 genes was observed, although ARGs generally decreased over time. In the amended and spiked microcosms, the microbial community was able to remove more than 99% of SMX in 36 days and the antibiotic did not bioaccumulate in the lettuce. Interestingly, where Cu and SMX were co-present, ARGs (particularly sul2) increased, showing how copper had a strong effect on resistance persistence in the soil. Copper also had a detrimental effect on the plant-microbiome system, affecting plant biomass and microbial activity in all conditions except in a digestate presence. When adding digestate microbial activity, biodiversity and lettuce biomass increased, with or without copper present. Not only did the microbial community favour plant growth, but lettuce also positively influenced its composition by increasing bacterial diversity and classes (e.g., Alphaproteobacteria) and genera (e.g., Bacillus), thus indicating a good-quality soil. Key points• Cattle digestate promoted the highest microbial activity, diversity, and plant growth • Cattle digestate counteracted detrimental contaminant effects • Cu presence promoted antibiotic cross-resistance in soil

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Increased risk of antibiotic resistance in surface water due to global warming

Zhao,

Ye,

et al. 2024

Environmental Research

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Association between antibiotic resistance and increasing ambient temperature in China: an ecological study with nationwide panel data

Cited by 27 publications

References 47 publications

Socioeconomic and Governance Factors Disentangle the Relationship between Temperature and Antimicrobial Resistance: A 10-Year Ecological Analysis of European Countries

Socioeconomic and Governance Factors Disentangle the Relationship between Temperature and Antimicrobial Resistance: A 10-Year Ecological Analysis of European Countries

Effects of sulfamethoxazole and copper on the natural microbial community from a fertilized soil

Increased risk of antibiotic resistance in surface water due to global warming

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