Association between APOC3 polymorphisms and non-alcoholic fatty liver disease risk: a meta-analysis

Abstract

Background and Aim: The apolipoprotein C3 (APOC3) polymorphism has been reported to predispose to non-alcoholic fatty liver disease (NAFLD). However, the results remain inconclusive. This meta-analysis aimed to provide insights into the association between APOC3 polymorphisms and NAFLD risk.
 Methods: Studies with terms “NALFD” and “APOC3” were retrieved from PubMed, Web of Science, CNKI and Wan- fang databases up to August 1, 2019. Pooled odds ratio (OR) and 95% confidence interval (95% CI) for the association of APOC3 polymorphisms and NAFLD risk were calculated using fixed and random-effects models.
 Results: A total of twelve studies from eleven articles were included. Of them, eight studies (1750 cases and 2181 controls) reported the strong association of variant rs2854116 with NAFLD and six studies (1523 cases and 1568 controls) found the association of rs2854117 polymorphism with NAFLD. Overall, a statistically significant association between rs2854116 pol- ymorphism of APOC3 gene and NAFLD risk was found only under dominant model. However, association of rs2854117 polymorphism with NAFLD risk was not detected under all four genetic models. In sub-group analysis of NAFLD subjects based on country, no association among them in China was detected. Besides, four studies analyze the association between the two polymorphisms and clinical characteristics in all subjects or NAFLD patients, and we also failed detect any associa- tion between the wild carriers and variant carriers.
 Conclusion: The meta-analyses suggests that the rs2854116 polymorphism but not rs2854117 polymorphism in APOC3 gene might be a risk factor for NAFLD among Asians. That is, individuals with CT+CC genotype have higher risk of devel- oping NAFLD. However, studies with sufficient sample size are needed for the further validation.
 Keywords: Apolipoprotein C3; polymorphism; non-alcoholic fatty liver disease; meta-analysis.

Editor’s choice: this December 2020

“…Even during this Covid-19 pandemic, NCDs are forever with thus: cardio-vascular disease nursing care, 21 hypertention, 22 HIV-exposed infants 23 , ECG abnormalities in HIV, 24 left ventricular hypertrophy, 25 epicardial fat, 26 aerobic exercise, 27 insulin resistance, 28 asthma, 29 COPD and sleep, 30 e cigarettes, 31 non- alcoholic liver disease, 32 home care, 33 Bilateral paediatric surgery, 34 self-harm, 35 MRI, 36 osteosarcoma risk, 37 thyroid 38 and gastric esophageal cancer; 39 fibromatosis, 40 prostate cancer, 41 neuro-endocrine tumour, 42 polycystic ovary and vitamin D deficiency, 43 micro RNAs and disease: 44 all will hopefully make us appreciate the burden and effect of this scourge on our people.…”

Nutritional Genomics in Nonalcoholic Fatty Liver Disease

“…Specifically, we will elaborate on four specific polymorphisms: PNPLA3, TM6SF2, PEMT, and CHDH, and highlight the dietary patterns/nutritional factors that are associated with their SNPs. Although other genes, such as apolipoprotein C3 (APOC3), and gene choline kinase alpha (CHKA) also seem to play a role in the genesis and development of NAFLD, their connections with nutrition and dietary patterns are still missing [9,17].…”

Association of sorting and assembly machinery component 50 homolog gene polymorphisms with nonalcoholic fatty liver disease susceptibility

“…[9] At present, genome-wide association studies (GWAS) have demonstrated several conspicuous genetic susceptibility genes such as PNPLA3, SAMM50, PARVB, APOC3, PPAR-γ, NCANCILP2, FABP1, AGTR1, GSTs, which had been verified the crucial roles in the disease onset and progression of NAFLD. [10][11][12][13][14][15] Among them, rs738491, rs2143571, and rs3761472 in the sorting and assembly machinery component 50 homolog (SAMM50) gene were demonstrated to be notably associated with NAFLD susceptibility. [16] Up to now, there have been several reports on SAMM50 gene SNPs and NAFLD susceptibility, but the results were inconsistent.…”