Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: A meta-analysis

Meng, Haixia; Mei, Qi; Yuan-yuan, YI; Liu, Yaping

doi:10.1007/s10815-013-0118-7

Cited by 16 publications

(17 citation statements)

References 16 publications

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“…Several reports showed no influence of APOE on recurrent miscarriage risk (10)(11)(12), while others linked APOE*4 (7,9,21,22) or APOE*2 (13) alleles with a higher risk for recurrent pregnancy loss. Two meta-analyses attempted to shed light on this issue, however, they too failed to reach a full consensus (23,24). In partial agreement with our results, Collazo et al reported an increased risk in pregnancy loss for women with the APOE*2 allele and a protective effect for APOE*4 carriers when compared with their APOE*33 counterparts (25).…”

Section: Discussionsupporting

confidence: 85%

Interaction of apolipoprotein E gene polymorphisms on miscarriage risk in black and white American women

Gamundi-Segura

Torres-Pérez

Sanz-París

et al. 2016

Fertility and Sterility

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Section: Discussionsupporting

confidence: 85%

Interaction of apolipoprotein E gene polymorphisms on miscarriage risk in black and white American women

Gamundi-Segura

Torres-Pérez

Sanz-París

et al. 2016

Fertility and Sterility

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“…Evidence from a meta-analysis of seven studies suggested that the APOE polymorphisms were associated with the risk of psoriasis, especially E2 and E3 alleles [ 33 ]. A meta-analysis of seven studies suggested an association between APOE E4 mutation and increased risk of recurrent pregnancy loss [ 34 ]. Evidence from a meta-analysis of 6977 subjects provides evidence that APOE E2 mutation is associated with multiple sclerosis risk [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population

et al. 2016

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BackgroundThe relationship between the apolipoprotein E (APOE) polymorphism and intracranial aneurysms has previously only been studied in Russia and Japan but not in Chinese populations. The purpose of this study was to investigate the association between APOE polymorphism and the risk of intracranial aneurysms in a Chinese population.MethodsThe study population consisted of 150 intracranial aneurysms patients and 150 matched control subjects. The APOE gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).ResultsPatients with intracranial aneurysms had a significantly higher frequency of APOE E2/E2 genotype [odds ratio (OR) =9.51, 95 % confidence interval (CI) = 1.19, 76.04; P = 0.03] and APOE E2/E3 genotype (OR = 1.87, 95 % CI = 1.03, 3.40; P = 0.04) than healthy controls. The APOE E4/E4 genotype frequencies (OR = 0.09, 95 % CI = 0.01, 0.74; P = 0.03) in the intracranial aneurysms group were significantly lower than those in the controls group. When stratified by the site, shape, size and the Fisher Grade of intracranial aneurysms, no statistically significant result was observed.ConclusionOur study suggested that APOE polymorphism might be associated with intracranial aneurysms in Chinese population. Additional studies are needed to confirm this finding.

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“…Some studies do not report an association between 4 status and fetal loss [56][57][58]. At least five studies and one meta-analysis report a positive association between possession of the 4 allele and fetal loss [59][60][61][62][63][64][65]. Several additional studies have examined the association between 4 carrier status and a variety of pregnancyrelated conditions.…”

Section: Reproduction and Development In Apolipoprotein 4 Carriers (Tmentioning

confidence: 99%

Putative Survival Advantages in Young Apolipoprotein ɛ4 Carriers are Associated with Increased Neural Stress

Smith

Ashford

Perfetti³

2019

JAD

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Inheritance of a single copy of the apolipoprotein E (APOE) 4 allele increases risk of Alzheimer's disease (AD) by 3-4-fold, with homozygosity associated with a 12-16-fold increase in risk, relative to 3 allele homozygosity. There is a decreased risk associated with the APOE 2 allele. The pathological consequence of APOE genotype has led to intense efforts to understand the mechanistic basis of the interplay between APOE status and loss of synapses. Numerous 4 allele-related associations have been reported with the potential relevance of these associations to the pathogenesis of AD unknown at this time. In primarily young subjects, we have reviewed a representative body of literature on 4 allele-associations related to the following: cardiovascular responses; impacts on reproduction and fetal development; co-morbidities; resistance to infectious disease; responses to head injury; biochemical differences possibly related to neural stress; and brain structure-function differences. In addition, the literature on the association between the 4 allele and cognitive performance has been reviewed comprehensively. The weight-of-the-evidence supports the hypothesis that possession of the ancestral 4 allele in youth is associated with improved fitness during fetal development, infancy, and youth relative to the more recently appearing 3 allele, at the expense of decreased fitness in old age, which is substantially improved by the 3 allele. However, possession of the 4 allele is also associated with higher levels of synaptic macromolecular turnover, which likely stresses basic cellular neuroplasticity mechanisms. Clinical trials of potential AD therapeutics should consider APOE status as an enrollment criterion. conceptualization of AD pathology dates from 1968 when Blessed et al. showed in elderly individuals that the NFTs correlated with the severity of the dementia, though the neuritic plaques, which contain cerebral amyloid-␤ (A␤), did not [2]. A major advance in understanding AD pathology was the demonstration that AD pathology predominantly affects the posterior-temporal, inferior parietal, posterior cingulate, and medial temporal region [3], with a characteristic pattern of progression beginning in the entorhinal cortex involving neurofibrillary (NF)

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Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: A meta-analysis

Cited by 16 publications

References 16 publications

Interaction of apolipoprotein E gene polymorphisms on miscarriage risk in black and white American women

Interaction of apolipoprotein E gene polymorphisms on miscarriage risk in black and white American women

Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population

Putative Survival Advantages in Young Apolipoprotein ɛ4 Carriers are Associated with Increased Neural Stress

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