Association between apolipoprotein E <i>ɛ</i>4 allele and apathy in probable Alzheimer's disease

Monastero, Roberto; Mariani, Elisabetta; Camarda, Cecilia; Ingegni, Tiziana; Averna, Maurizio; Senin, Umberto; Camarda, Rosolino; Mecocci, Patrizia

doi:10.1111/j.1600-0447.2005.00597.x

Cited by 34 publications

(20 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other reports suggested that in AD the APOE e4 allele may be protective against depression (Ballard et al, 1997), or that e2-carriers may be at higher risk of depressive symptoms (Holmes et al, 1996;Holmes et al, 1997;Holmes et al, 1998), or reported no association between APOE polymorphism and depression (Cantillon et al, 1997;Forsell et al, 1997;Harwood et al, 1999;Craig et al, 2005;Borroni et al, 2006;Hollingworth et al, 2006) or anxiety (Hirono et al, 1999;Levy et al, 1999;Gabryelewicz et al, 2002). Furthermore, our results on an increased risk of apathetic syndrome (i.e., NPI symptoms apathy and eating abnormalities) in AD patients APOE e4-carriers confirmed previous findings suggesting a relationship between the APOE e4 allele and apathy in patients with AD (Monastero et al, 2006), although other studies did not show any correlation between apathy endophenotype (Borroni et al, 2006) or NPI apathy symptom (van der Flier et al, 2007) and APOE polymorphism.…”

Section: Discussionsupporting

confidence: 92%

The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes

Seripa

Sancarlo

Paris

et al. 2010

Int J Geriat Psychiatry

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 92%

The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes

Seripa

Sancarlo

Paris

et al. 2010

Int J Geriat Psychiatry

View full text Add to dashboard Cite

show abstract

“…However, they found an association with the APOE ε 3/ ε 4 genotype, but not with the APOE ε 4/ ε 4 genotype or the e4 allele [27], so confirming a previous study in which anxiety appeared more frequently in APOE ε 3/ ε 4 demented patients, although this difference was not statistically significant [56]. Finally, when AD patients were subdivided according to the European Alzheimer's Disease Consortium classification of neuropsychiatric syndromes, for the affective syndrome (i.e., AD patients with the NPI symptoms depression and anxiety), these previous findings in AD and demented patients [27, 73, 74] were confirmed suggesting that the presence of an APOE ε 4 allele may be a risk factor also for anxiety symptoms [56]. …”

Section: Apoe Genotypes and Affective Syndromes/endophenotypes In supporting

confidence: 87%

Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late‐Onset Alzheimer′s Disease: Focus on APOE Gene

Seripa

Frisardi

Solfrizzi

et al. 2011

International Journal of Alzheimer's Disease

View full text Add to dashboard Cite

Neuropsychiatric symptoms, previously denominated as behavioural and psychological symptoms of dementia, are common features of Alzheimer's disease (AD) and are one of the major risk factors for institutionalization. At present, the role of the apolipoprotein E (APOE) gene in the development of neuropsychiatric symptoms in AD patients is unclear. In this paper, we summarized the findings of the studies of neuropsychiatric symptoms and neuropsychiatric syndromes/endophenotypes in AD in relation to APOE genotypes, with special attention to the possible underlying mechanisms. While some studies failed to find a significant association between APOE and neuropsychiatric symptoms in late-onset AD, other studies reported a significant association between the APOE ε4 allele and an increase in agitation/aggression, hallucinations, delusions, and late-life depression or anxiety. Furthermore, some negative studies that focused on the distribution of APOE genotypes between AD patients with or without neuropsychiatric symptoms further emphasized the importance of subgrouping neuropsychiatric symptoms in distinct neuropsychiatric syndromes. Explanations for the variable findings in the existing studies included differences in patient populations, differences in the assessment of neuropsychiatric symptomatology, and possible lack of statistical power to detect associations in the negative studies.

show abstract

“…However, among ApoE ε4 noncarriers, the MCI subjects had lower premorbid and current neuroticism and higher premorbid and current extraversion scores compared to the control subjects, whereas the MCI patients and the control subjects who were ApoE ε4 carriers obtained similar scores. To our knowledge, this is the first study reporting on ApoE status in relation to personality traits in MCI, although there are a number of investigations into BPS as state markers in AD showing contradictory findings as to their association with the ApoE ε4 genotype [18,19,20,21,22,23,24,25]. Our results may be a chance finding given the preliminary nature of this study.…”

Section: Discussioncontrasting

confidence: 47%

“…Apolipoprotein E ε4 allele (ApoE ε4) and tau protein were associated with MCI conversion to AD [15,16,17]. Moreover, BPS as state markers in AD have been found to be associated with ApoE ε4 and less with ApoE ε3 genotypes [18,19,20,21,22,23], although some studies contradict such findings [24,25]. We have found no studies reporting on ApoE status in relation to BPS and personality traits in MCI.…”

Section: Introductionmentioning

confidence: 99%

The Evolution of Personality in Patients with Mild Cognitive Impairment

Donati

Studer

Petrillo

et al. 2013

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Aims: To describe personality traits and their changes in mild cognitive impairment (MCI) and control subjects. Methods: Sixty-three MCI and 90 control subjects were asked to describe their current personality traits by the Structured Interview for the Five-Factor Model (SIFFM). For each subject, a close relative retrospectively assessed these descriptions both as to the previous and current personality traits, using the Revised NEO Personality Inventory, Form R (NEO-PI-R). Results: Self-assessed MCI subjects reported significantly lower scores in the openness dimension than control subjects [F(1, 150) = 9.84, p = 0.002, η_p² = 0.06]. In current observer ratings, MCI subjects had higher scores on neuroticism [F(1, 137) = 7.55, p = 0.007, η_p² = 0.05] and lower ones on extraversion [F(1, 137) = 6.40, p = 0.013, η_p² = 0.04], openness [F(1, 137) = 9.93, p = 0.002, η_p² = 0.07], agreeableness [F(1, 137) = 10.18, p = 0.002, η_p² = 0.07] and conscientiousness [F(1, 137) = 25.96, p < 0.001, η_p² = 0.16]. Previous personality traits discriminated the groups as previous openness [odds ratio (OR) = 0.97, 95% confidence interval (CI) = 0.95-0.99, p = 0.014] and conscientiousness (OR = 0.96, 95% CI 0.94-0.98, p = 0.001) were negatively related to MCI group membership. In MCI subjects, conscientiousness [F(1, 137) = 19.20, p < 0.001, η_p² = 0.12] and extraversion [F(1, 137) = 22.27, p < 0.001, η_p² = 0.14] decreased between previous and current evaluations and neuroticism increased [F(1, 137) = 22.23, p < 0.001, η_p² = 0.14], whereas no significant change was found in control subjects. Conclusions: MCI subjects undergo significant personality changes. Thus, personality assessment may aid the early detection of dementia.

show abstract

Association between apolipoprotein E ɛ4 allele and apathy in probable Alzheimer's disease

Abstract: Our results suggest a relationship between the ApoE epsilon4 allele and apathy in patients with AD.

Cited by 34 publications

References 42 publications

The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes

The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes

Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late‐Onset Alzheimer′s Disease: Focus on APOE Gene

The Evolution of Personality in Patients with Mild Cognitive Impairment

Contact Info

Product

Resources

About